12 Questions
Why can't blastocyst culture be used as the sole means of identifying chromosomally abnormal embryos?
Aneuploid embryos can still form blastocysts, albeit at lower rates.
How are uterine contractions related to the success of embryo transfer?
Uterine contractions have been negatively correlated with embryo transfer outcome, possibly leading to embryonic expulsion and loss.
Why is cryopreservation of embryos at the blastocyst stage considered more successful?
Cryopreservation at the blastocyst stage appears to have higher success rates than at earlier stages.
What advantage does trophectoderm biopsy offer over using cleavage-stage embryos for genetic screening?
Trophectoderm biopsy allows the removal of more cells and facilitates the use of next-generation sequencing.
What is a potential disadvantage of offering only blastocyst culture and transfer in a program?
The possibility that a patient may not have a morula or blastocyst for transfer.
Why did some clinics see an increase in the percentage of patients not having an embryo transfer with blastocyst culture?
Despite an increase in patients not having an embryo transfer, there was a significant increase in pregnancy rate per retrieval.
Why is it difficult to identify embryos with the highest developmental potential within a given cohort?
Because embryos need to be cultured past the maternal/embryonic genome transition up to the blastocyst stage to be able to identify those with limited or no developmental potential.
What is the significance of assessing the quality of the oocyte in the context of embryo development?
The quality of the developing embryo is ultimately dependent on the quality of gametes from which it is derived.
Why do not all fertilized oocytes lead to a successful pregnancy or term birth?
Because a percentage of fertilized oocytes are abnormal and not destined to establish a pregnancy or go to term.
How have some studies attempted to increase implantation rates in assisted reproductive technologies?
By assessing pronucleate-stage oocytes or using a scoring system on day 3 to select embryos for transfer.
What is the impact of male gamete quality on embryo development?
The male gamete's impact on development is eliminated when assessing embryos based on the quality of the oocyte alone.
Why do many abnormal embryos arrest during development in vitro?
Due to factors like insufficiency of stored oocyte-coded gene products and failure to activate the embryonic genome.
Learn about assessing embryo development potential based on culturing embryos up to the blastocyst stage. Understand the impact of assessing pronucleate-stage oocytes on implantation rates.
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