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Electrical Stimulation of Denervated Muscle

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Electrical Stimulation of Denervated Muscle

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Questions and Answers

Which of the following is the primary rationale for electrically stimulating denervated muscle?

To impede the regeneration of injured axons

To facilitate functional recovery following reinnervation (correct)

To accelerate the degeneration of neuromuscular junctions

To prevent muscle atrophy

What is a physiological change that occurs in muscles following denervation?

Alteration in electrical properties of the membrane (correct)

Increase in neuromuscular junctions integrity

Decrease in subsarcolemmal nuclei

Reduction in synthesis of the sarcoplasmic reticulum

What is a biochemical change that occurs in muscles following denervation?

Decrease in synthesis of the sarcoplasm (correct)

Transient decrease in the subsarcolemmal nuclei

Reduction in lysosomes

Increase in trophic substances supply from motoneurons

What change occurs in muscle contraction time following denervation?

Increase Signup and view all the answers

Prior to denervation, what maintains the physiologic integrity of muscle fibers?

Continuous supply of trophic substances from the motoneurons Signup and view all the answers

What is the rationale behind exercising denervated muscle?

To facilitate functional recovery following reinnervation Signup and view all the answers

Which of the following is a potential benefit of electrical stimulation of denervated muscle?

Delays muscle fiber degeneration and fibrosis Signup and view all the answers

What is the most obvious change observed following denervation?

Reduction in the diameter of individual muscle fibers Signup and view all the answers

Why may intense stimuli (i.e., 25 mA) cause limited reinnervation in some studies?

It causes local trauma to the newly forming neuromuscular junctions Signup and view all the answers

What happens if reinnervation has not occurred within 2 years following denervation?

All contractile elements of the muscle are replaced by fibrous connective tissue Signup and view all the answers

Why did many investigators and clinicians report that electrical stimulation only retarded the atrophy and did not prevent it?

The intensity of the stimuli may have left deeper fibers unaffected Signup and view all the answers

What is a possible reason for lack of success in facilitating reinnervation using electrical stimulation in some studies?

Intensity of the stimuli causing local trauma to newly forming neuromuscular junctions Signup and view all the answers

What may disrupt regenerating neuromuscular junctions and subsequently delay reinnervation?

Contraction of the denervated muscle Signup and view all the answers