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Questions and Answers
Which physiological factor contributes to the decreased excretion of drugs like Digoxin and lithium in the elderly?
Which physiological factor contributes to the decreased excretion of drugs like Digoxin and lithium in the elderly?
- Impaired liver functions
- Decreased plasma protein binding
- Impaired kidney functions (correct)
- Increased sensitivity to CNS depressants
What effect does decreased plasma protein binding have on drug activity in the elderly?
What effect does decreased plasma protein binding have on drug activity in the elderly?
- It enhances drug excretion
- It increases drug metabolism
- It decreases the half-life of drugs
- It leads to greater amounts of active drugs (correct)
Why do elderly individuals often require lesser drug doses compared to adults?
Why do elderly individuals often require lesser drug doses compared to adults?
- They have higher plasma protein binding
- They have increased drug excretion
- They are prone to adverse drug reactions (correct)
- Their liver functions are enhanced
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