Elderly Drug Dosing
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Questions and Answers

Which physiological factor contributes to the decreased excretion of drugs like Digoxin and lithium in the elderly?

  • Impaired liver functions
  • Decreased plasma protein binding
  • Impaired kidney functions (correct)
  • Increased sensitivity to CNS depressants

    • What effect does decreased plasma protein binding have on drug activity in the elderly?

  • It enhances drug excretion
  • It increases drug metabolism
  • It decreases the half-life of drugs
  • It leads to greater amounts of active drugs (correct)

    • Why do elderly individuals often require lesser drug doses compared to adults?

  • They have higher plasma protein binding
  • They have increased drug excretion
  • They are prone to adverse drug reactions (correct)
  • Their liver functions are enhanced

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