Eicosanoids and NSAIDs Quiz

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Questions and Answers

What enzyme is responsible for releasing eicosanoids from cell membranes?

Phospholipase A2 (correct)
Phospholipase D
Phospholipase C
Phospholipase B1

In what circumstances are eicosanoids synthesized and released?

When cells are at rest
During normal cellular metabolism
In response to IgE-mediated reactions, inflammatory mediators, trauma, heat, and toxins (correct)
In response to hormonal changes

Which eicosanoid is cytoprotective in the stomach?

Thromboxane (TxA2)
Prostaglandins (PGs) (correct)
Prostacyclin
Leukotrienes

What is the primary function of thromboxane (TxA2)?

<p>Causes platelet aggregation (A)</p> Signup and view all the answers

What are eicosanoids synthesized from?

<p>Arachidonic acid (A)</p> Signup and view all the answers

Flashcards

Enzyme for eicosanoid release

Phospholipase A2 breaks down cell membranes to release arachidonic acid, the precursor to eicosanoids.

Eicosanoid trigger

Eicosanoids are produced in response to immune reactions, inflammation, injury, or toxins.

Stomach's cytoprotective eicosanoid

Prostaglandins (PGs) protect the stomach lining.

Thromboxane's main function

Thromboxane A2 (TxA2) causes platelets to clump together.

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Eicosanoid precursor

Eicosanoids are made from arachidonic acid.

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Study Notes

Eicosanoid Synthesis and Function

Phospholipase A2 is the enzyme responsible for releasing eicosanoids from cell membranes.
Eicosanoids are synthesized and released in response to inflammation, injury, or immune response.
Prostaglandin E2 (PGE2) is cytoprotective in the stomach, protecting it from acid and other damages.
The primary function of thromboxane (TxA2) is to induce platelet aggregation and vasoconstriction.
Eicosanoids are synthesized from arachidonic acid, a 20-carbon fatty acid derived from phospholipids in cell membranes.

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Description

Test your knowledge of eicosanoids and NSAIDs with this quiz designed by Dr. Rasha Bakheet. Differentiate between leukotrienes, prostaglandins, and thromboxanes, and demonstrate your understanding of their pharmacology. Sharpen your understanding of cell-regulating polyunsaturated fatty acids and their role in cell membrane regulation.