Podcast
Questions and Answers
Which receptor family do growth hormone cell surface receptors belong to?
Which receptor family do growth hormone cell surface receptors belong to?
- Receptor tyrosine kinases
- Ligand-gated ion channels
- G protein-coupled receptors
- JAK/STAT cytokine receptor superfamily (correct)
What is the primary mediator of the growth-promoting effects of growth hormone?
What is the primary mediator of the growth-promoting effects of growth hormone?
- Receptor-associated JAK tyrosine kinases
- STATs
- Insulin-like growth factor 1 (IGF-1) (correct)
- Insulin-like growth factor 2 (IGF-2)
Where is much of the circulating IGF-1 produced?
Where is much of the circulating IGF-1 produced?
- Kidney
- Muscle
- Liver (correct)
- Bone
What role does growth hormone play in longitudinal bone growth?
What role does growth hormone play in longitudinal bone growth?
In which tissues does growth hormone stimulate the production of IGF-1?
In which tissues does growth hormone stimulate the production of IGF-1?
What effect does growth hormone have on insulin sensitivity?
What effect does growth hormone have on insulin sensitivity?
In patients unable to respond to endogenous GH due to mutated GH receptors, how does IGF-1 affect serum glucose and insulin?
In patients unable to respond to endogenous GH due to mutated GH receptors, how does IGF-1 affect serum glucose and insulin?
What is a common presentation of GH deficiency in childhood?
What is a common presentation of GH deficiency in childhood?
What are the effects of GH on lipid and carbohydrate metabolism throughout postnatal life?
What are the effects of GH on lipid and carbohydrate metabolism throughout postnatal life?
Why are neonates with isolated GH deficiency of normal size at birth?
Why are neonates with isolated GH deficiency of normal size at birth?
What is the primary mediator of the growth-promoting effects of growth hormone?
What is the primary mediator of the growth-promoting effects of growth hormone?
How does growth hormone affect body composition?
How does growth hormone affect body composition?
Which receptor-associated proteins are involved in the signaling cascades of growth hormone?
Which receptor-associated proteins are involved in the signaling cascades of growth hormone?
When does longitudinal bone growth stop under the influence of growth hormone?
When does longitudinal bone growth stop under the influence of growth hormone?
Where is much of the circulating IGF-1 produced?
Where is much of the circulating IGF-1 produced?
What effect does growth hormone have on insulin sensitivity?
What effect does growth hormone have on insulin sensitivity?
In patients who are unable to respond to endogenous GH due to mutated GH receptors, how does IGF-1 affect serum glucose and insulin?
In patients who are unable to respond to endogenous GH due to mutated GH receptors, how does IGF-1 affect serum glucose and insulin?
What can cause growth hormone deficiency in individuals?
What can cause growth hormone deficiency in individuals?
What is a key characteristic of GH deficiency in childhood?
What is a key characteristic of GH deficiency in childhood?
How does IGF-1 primarily act in patients with mutated GH receptors?
How does IGF-1 primarily act in patients with mutated GH receptors?
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