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Questions and Answers
What is the purpose of ligating one side of the ureter during the procedure?
What is the purpose of ligating one side of the ureter during the procedure?
- To facilitate the insertion of the catheter (correct)
- To measure the impact of furosemide on urine output
- To allow urine to drain more freely
- To prevent the flow of urine completely
What is the dosage of furosemide administered to the rabbits based on their weight?
What is the dosage of furosemide administered to the rabbits based on their weight?
- 0.5 ml/kg
- 10 mg/kg
- 1 ml/kg
- 5 mg/kg (correct)
How long is urine collected after administering furosemide?
How long is urine collected after administering furosemide?
- 5 minutes (correct)
- 2 minutes
- 3 minutes
- 10 minutes
What method is used to anaesthetize the rabbits before the procedure?
What method is used to anaesthetize the rabbits before the procedure?
What is the first step after anesthetizing the rabbit for the procedure?
What is the first step after anesthetizing the rabbit for the procedure?
Flashcards
Furosemide
Furosemide
A drug that increases urine production, commonly used to treat heart failure and high blood pressure. It works by blocking the reabsorption of sodium and chloride in the kidneys, leading to increased water excretion.
Operation
Operation
The process of making a small cut in the abdomen to access the bladder and ureters, allowing for the placement of a catheter for collecting urine.
Ureter
Ureter
The part of the urinary system that carries urine from the kidneys to the bladder, also known as the 'urine tube'.
Catheter
Catheter
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Administration
Administration
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Study Notes
Effects of Furosemide on Rabbit Urine
- Study investigated furosemide's impact on rabbit urine output.
- Conducted at Binzhou Medical University, Department of Pharmacology.
Experimental Materials
- Animals: Rabbits weighing 2-3 kg.
- Drugs: 25% ethyl carbamate (urethane), 1% furosemide, liquid paraffin, normal saline.
- Instruments: Rabbit operating table, surgical apparatus, 100ml beakers, cannula, plastic catheter, syringe.
Method and Procedure
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Anesthetization: Rabbits were weighed and anesthetized via intravenous injection (marginal vein of the ear) with 25% ulatane (4ml/kg).
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Fixation: Rabbits were securely fixed supine on the operating table.
-
Operation:
- A 4-6 cm incision was made along the midline of the abdomen, focusing on the bladder region.
- The bladder and ureters were located and identified.
- One ureter was carefully separated (approximately 2 cm) and ligated at its proximal end.
- A catheter was filled with water, and a small 'V'-shaped opening was created above the ligation site to insert the catheter into the ureter towards the kidney.
- Urine flow confirmation indicated successful catheter insertion and no blockages.
- The catheter was secured with thread to prevent slippage.
- The distal catheter end was placed in a beaker to collect urine.
- Urine drops were counted over a 5-minute period.
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Administration:
- After the initial 5-minute urine collection, 0.5 ml/kg (equivalent to 5 mg/kg) of 1% furosemide was injected into the marginal vein of the rabbit's ear.
- Urine drops were subsequently counted in 3 consecutive 5-minute intervals following furosemide administration.
Results
- Data collection is required to analyze furosemide's effect on urine output (before and after administration).
- A table was provided to record the results. The table is titled "Table Effect of furosemide on amount of urine".
- The table includes columns for Drug, Dose (mg/kg), Before (administration), and After administration (0-5 min, 5-10 min, 10-15 min).
- The dose of furosemide was 5 mg/kg.
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