Podcast
Questions and Answers
Why is the choice of drug administration route important?
Why is the choice of drug administration route important?
- It solely depends on the color of the drug.
- It only matters for drugs administered to children.
- It depends on the physical and chemical properties of the drug and the desired speed of action. (correct)
- It's only relevant for drugs used to treat chronic conditions.
What is the significance of 'righting reflex' in the context of studying CNS depressants?
What is the significance of 'righting reflex' in the context of studying CNS depressants?
- It shows the animal's resistance to CNS depressants.
- It measures the animal's physical strength.
- It represents the animal's preference for a particular drug.
- It indicates the animal's ability to maintain balance, which is affected by CNS depressants. (correct)
Why is it important to choose a drug with a well-defined response when studying the influence of changing the route of administration?
Why is it important to choose a drug with a well-defined response when studying the influence of changing the route of administration?
- To make the experiment more visually appealing.
- To minimize the cost of the experiment.
- To ensure the drug is easy to obtain.
- To clearly observe and record the effects of different administration routes on the drug's action. (correct)
Pentobarbital is classified as what type of drug in the experiment?
Pentobarbital is classified as what type of drug in the experiment?
How do sedative drugs affect the recipient?
How do sedative drugs affect the recipient?
What effect do hypnotic drugs primarily produce?
What effect do hypnotic drugs primarily produce?
How are barbiturates classified?
How are barbiturates classified?
What is a defining characteristic of short-acting barbiturates?
What is a defining characteristic of short-acting barbiturates?
How long does the duration of action of intermediate-acting barbiturates typically last?
How long does the duration of action of intermediate-acting barbiturates typically last?
Which of the following is TRUE regarding long-acting barbiturates?
Which of the following is TRUE regarding long-acting barbiturates?
What is the correct order of CNS depression as dosage increases?
What is the correct order of CNS depression as dosage increases?
What is the 'onset of drug action' defined as?
What is the 'onset of drug action' defined as?
What does 'duration of action' refer to?
What does 'duration of action' refer to?
What is the 'righting reflex'?
What is the 'righting reflex'?
In the context of drug administration, what does achieving a 'certain required concentration' at the site of action ensure?
In the context of drug administration, what does achieving a 'certain required concentration' at the site of action ensure?
If a drug's administration route results in a slower onset of action, what might be a potential consequence?
If a drug's administration route results in a slower onset of action, what might be a potential consequence?
A drug that decreases activity and calms the recipient is best described as a:
A drug that decreases activity and calms the recipient is best described as a:
Which of the following is an example of short acting barbiturates and is used in the IV induction of anesthesia?
Which of the following is an example of short acting barbiturates and is used in the IV induction of anesthesia?
Which of the options is the best example of intermediate acting barbiturates?
Which of the options is the best example of intermediate acting barbiturates?
Which of the options is an example of long acting barbiturates?
Which of the options is an example of long acting barbiturates?
Flashcards
Drug Effects
Drug Effects
A drug's effect is seen only when it reaches a concentration at its site of action.
Drug Route Choice
Drug Route Choice
Factors include physical/chemical properties and desired speed of action.
Drug Selection
Drug Selection
A drug is chosen which has a clear and easily observed response.
CNS Depressants
CNS Depressants
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Sedative
Sedative
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Hypnotic
Hypnotic
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Barbiturates
Barbiturates
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Thiopental
Thiopental
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Pentobarbital
Pentobarbital
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Phenobarbital
Phenobarbital
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Onset of Drug Action
Onset of Drug Action
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Duration of Action
Duration of Action
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Righting Reflex
Righting Reflex
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Study Notes
- This lab demonstration focuses on the influence of changing the route of administration on pharmacological response.
Introduction
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A drug exerts its effect only after reaching a certain concentration at its target site.
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The choice of drug administration route depends on the drug's physical and chemical properties and how quickly the effect is needed.
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To study the influence of changing administration routes, it's important to choose a drug with a well-defined response.
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A CNS depressant will be used, producing a clear-cut response.
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The loss of the righting reflex will be recorded to determine the onset and duration of the drug's effect.
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Pentobarbitone sodium (6mg/1ml) at a dose of 35mg/kg is used as a sedative-hypnotic drug in the experiment.
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Sedatives decrease activity and calm the recipient.
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Hypnotics produce drowsiness and sleep.
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Pentobarbital belongs to the CNS depressant group called Barbiturates.
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Barbiturates are classified into three subgroups based on the duration of their effects: short, intermediate, and long-acting.
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Short-acting barbiturates: Example is Thiopental, which acts within seconds, has a duration of about 30 minutes, used for IV induction of anesthesia.
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Intermediate-acting barbiturates: Example is Pentobarbital, with a duration of action between 3-8 hours, used as a sedative-hypnotic drug.
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Long-acting barbiturates: Example is Phenobarbital, the duration of action is more than one day (1-2 days), used in the treatment of seizures.
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Dose-dependent continuous CNS depression progresses through stages: Sedation > Hypnosis > Anesthesia > Coma > Death.
Comparing Influences
- Onset of drug action: The speed at which the drug reaches the site of action and produces an observable effect.
- Duration of action: The length of time between the appearance and disappearance of action.
Righting Reflex
- The righting reflex is defined as the ability of an animal to return to its normal position when placed on its back (supine position).
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