Effects of Cocaine and Amphetamines on Dopamine Reuptake
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Questions and Answers

Which type of ADHD involves symptoms of both hyperactive-impulsive and inattentive types?

  • Combined type (correct)
  • Hyperactive type
  • Impulsive type
  • Inattentive type

What is a common characteristic of the hyperactive-impulsive type of ADHD?

  • Being impulsive
  • Daydreaming
  • Fidgeting and talking a lot (correct)
  • Difficulty waiting for turn

What is a key feature that helps differentiate the diagnosis of ADHD in children?

  • EEG-based assessment
  • Medical history and social factors (correct)
  • Family history of ADHD
  • Physical exam only

What does the NEBA system specifically measure to help diagnose ADHD?

<p>Brain waves (THETA and BETA) (A)</p> Signup and view all the answers

Which behaviour is commonly observed in children with ADHD according to the text?

<p>Constantly interrupting others (B)</p> Signup and view all the answers

What ratio of brain waves has been shown to be higher in children with ADHD according to the NEBA system?

<p>Theta/Beta (B)</p> Signup and view all the answers

What aspect of physical health is screened during the diagnosis tests for ADHD to rule out physical issues?

<p>Vision and hearing (B)</p> Signup and view all the answers

What is a common feature observed in children with the hyperactive-impulsive type of ADHD?

<p>Difficulty sitting still for long periods (A)</p> Signup and view all the answers

What is the primary role of pharmaceutical manufacturers in drug development?

<p>Producing drugs (D)</p> Signup and view all the answers

Why is selectivity important in drug development?

<p>To avoid hitting unintended targets (B)</p> Signup and view all the answers

Which organelle in the liver controls protein synthesis?

<p>mTORC1 (D)</p> Signup and view all the answers

What health condition can result from mTORC1 affecting cardiomyocytes?

<p>Cardiac disease (D)</p> Signup and view all the answers

Which cellular component is negatively impacted by mTORC1 in arterial wall macrophages?

<p>Lipid burden (D)</p> Signup and view all the answers

How does hitting unintended targets during drug development affect side effects?

<p>Increases side effects (D)</p> Signup and view all the answers

In the context of drug development, what does specificity refer to?

<p>&quot;On-target&quot; effects (A)</p> Signup and view all the answers

How does NAP1051 differ from LXA4?

<p>NAP1051 has a longer half-life (D)</p> Signup and view all the answers

Which common strategy is NOT used to address low drug solubility?

<p>Antioxidants (D)</p> Signup and view all the answers

Why are cyclodextrins effective in enhancing drug solubility?

<p>Because they form inclusion complexes with drugs (D)</p> Signup and view all the answers

What role does the bucket structure of cyclodextrins play in enhancing drug solubility?

<p>It allows inclusion of lipid drugs in the hydrophobic cavity (A)</p> Signup and view all the answers

What is a key implication of modifying an anti-inflammatory drug to have a longer half-life?

<p>Increased effectiveness as an anti-inflammatory (B)</p> Signup and view all the answers

Why can NAP1051 not be put in solution due to its lower solubility in water?

<p>Its poor water solubility prevents it from forming a solution (B)</p> Signup and view all the answers

Which approach would be most suitable for enhancing the solubility of a poorly soluble drug that tends to aggregate?

<p>Forming inclusion complexes with cyclodextrins (D)</p> Signup and view all the answers

What is the most effective mechanism through which cyclodextrins enhance drug solubility?

<p>Enhancing drug dissolution through increased surface area (D)</p> Signup and view all the answers

What is the purpose of Black Box Warnings for medications?

<p>To alert consumers about serious or life-threatening side effects or risks (C)</p> Signup and view all the answers

What symptoms are associated with the adverse effects of certain medications when taken in combination with others?

<p>Lead-pipe rigidity, unstable blood pressure, tachycardia, and fever (C)</p> Signup and view all the answers

How do Medication Guides aim to help patients and caregivers?

<p>By alerting them to the risk of suicidal thinking and behavior (A)</p> Signup and view all the answers

What is the significance of the boldfaced text at the beginning of prescription inserts for antidepressants?

<p>It warns about the increased risk of suicidality in children and adolescents (C)</p> Signup and view all the answers

What kind of risks are Medication Guides intended to inform patients and caregivers about?

<p>The risk of suicidal thinking and behavior (C)</p> Signup and view all the answers

Why is it important for consumers to be aware of Black Box Warnings?

<p>To draw attention to serious or life-threatening side effects or risks (C)</p> Signup and view all the answers

Which term describes a warning that is assigned by the Food and Drug Administration indicating major risks of a drug?

<p>'Black Box' Warnings (A)</p> Signup and view all the answers

What is a common symptom associated with rhabdomyolysis when caused by certain medications?

<p>'Tea-colored' urine (B)</p> Signup and view all the answers

How does cocaine affect dopamine reuptake in the brain?

<p>It blocks dopamine reuptake by binding to dopamine transporters. (C)</p> Signup and view all the answers

What are the behavior effects of recreational doses of amphetamines and cocaine?

<p>Increased mental and physical activation (B)</p> Signup and view all the answers

How do cocaine and amphetamines affect blood pressure and heart rate?

<p>They increase both heart rate and blood pressure. (C)</p> Signup and view all the answers

What is the main physiological effect of amphetamines on autonomic responses?

<p>Bronchial dilation (B)</p> Signup and view all the answers

Which receptor type are D1 and D5 receptors classified as?

<p>Gs coupled receptors (C)</p> Signup and view all the answers

What is an example of a medication that contains both D and L isomers of amphetamine?

<p>Adderall (C)</p> Signup and view all the answers

What is the mechanism of action of caffeine in the brain?

<p>Non-selective inhibition of phosphodiesterase (D)</p> Signup and view all the answers

What is the main effect of methylxanthines on adenosine receptors in the heart?

<p>Antagonism of adenosine receptors slowing down heart rate. (A)</p> Signup and view all the answers

Which therapy may be effective for suppressing melatonin according to the text?

<p>Bright light Therapy with blue wavelength (B)</p> Signup and view all the answers

What patient-specific factors, in conjunction with guideline recommendations, should guide treatment choices for depression?

<p>Individual factors and guideline recommendations (A)</p> Signup and view all the answers

What is a common complementary therapy mentioned in the text for treating depression?

<p>Folic acid supplementation (D)</p> Signup and view all the answers

Which mental illness often leads to suicide according to the text?

<p>Depression (D)</p> Signup and view all the answers

What is a potential side effect of a permanent medical device according to the text?

<p>Temporary hoarseness (A)</p> Signup and view all the answers

Why is being proactive with counseling highlighted in the text regarding depression treatment?

<p>To have a profound impact on someone's life (B)</p> Signup and view all the answers

What is the role of Omega 3 fatty acids in treating depression?

<p>Reducing inflammation and improving mood regulation (B)</p> Signup and view all the answers

What can be considered essential when deciding treatment choices for depression?

<p>Considering patient-specific factors along with guideline recommendations (C)</p> Signup and view all the answers

What is the primary implication of modifying an anti-inflammatory drug to have a longer half-life?

<p>Improved drug delivery (D)</p> Signup and view all the answers

Which common strategy is NOT used to address low drug solubility?

<p>Probiotics (A)</p> Signup and view all the answers

Why is cyclodextrin effective in enhancing drug solubility?

<p>It increases surface area for dissolution (B)</p> Signup and view all the answers

What is the most likely reason why NAP1051 cannot be put in solution due to its solubility characteristics?

<p>Low water solubility (C)</p> Signup and view all the answers

How do inclusion complexes with cyclodextrins enhance drug solubility?

<p>By disrupting drug aggregation (B)</p> Signup and view all the answers

What is the main reason for considering the device used to deliver an anti-inflammatory drug with low water solubility?

<p>To improve drug bioavailability (B)</p> Signup and view all the answers

Which common approach is suitable for enhancing the solubility of a poorly soluble drug that tends to aggregate?

<p>Utilizing co-crystals (A)</p> Signup and view all the answers

What is the main advantage of forming inclusion complexes with cyclodextrins to enhance drug solubility?

<p>Increasing drug dissolution efficiency (D)</p> Signup and view all the answers

What is the primary role of norepinephrine among the neurotransmitters mentioned in the text?

<p>Responsible for activity and arousal (A)</p> Signup and view all the answers

Which neurotransmitter plays a crucial role in controlling reward, motivation, memory, and attention?

<p>Dopamine (D)</p> Signup and view all the answers

What is the primary function of CNS stimulants in treating ADHD symptoms?

<p>Improving attention span and reducing impulsivity (B)</p> Signup and view all the answers

What is the significance of adding shorter-acting stimulants for individuals with faster metabolism as mentioned in the text?

<p>To provide consistent coverage throughout the day (B)</p> Signup and view all the answers

Among the neurotransmitters discussed, which one is primarily responsible for mood regulation and endocrine secretions?

<p>Serotonin (D)</p> Signup and view all the answers

Which statement accurately describes the long-acting CNS stimulant medications according to the text?

<p>Take longer to act but provide coverage for an extended period (A)</p> Signup and view all the answers

What percentage of children diagnosed with ADHD were reported to be taking ADHD medication according to the 2016 CDC data?

<p>60% (C)</p> Signup and view all the answers

"Amphetamine (Adderall XR)" belongs to which category of CNS stimulants based on the information provided?

<p>&quot;Long-acting stimulants&quot; (D)</p> Signup and view all the answers

What is the primary goal in ADHD with regards to dopamine and norepinephrine?

<p>To maintain DA and NE in the synapse as long as possible (C)</p> Signup and view all the answers

What is the main effect of amphetamine on dopamine release?

<p>Diffuses into vesicles causing DA release into cytoplasm (C)</p> Signup and view all the answers

Which of the following side effects is NOT associated with stimulants?

<p>Limb numbness due to vasodilation (D)</p> Signup and view all the answers

What is the formulation of Adderall XR?

<p>5-30 mg increments of 5 mg (B)</p> Signup and view all the answers

What is included in the amphetamine mixture of Adderall?

<p>Dextroamphetamine sulfate and saccharate, as well as amphetamine sulfate and aspartate (C)</p> Signup and view all the answers

When should the last dose of immediate-release amphetamine be given?

<p>6 hours prior to bedtime (C)</p> Signup and view all the answers

Which property describes Adderall XR among the listed options?

<p>Single-entity of mixed amphetamine salts (B)</p> Signup and view all the answers

What is the function of amphetamine in relation to dopamine and norepinephrine transporters?

<p>Reverses flow by blocking reuptake of DA and NE (B)</p> Signup and view all the answers

Which group of antidepressants was discovered first?

<p>Monoamine oxidase inhibitors (MAOIs) (D)</p> Signup and view all the answers

What is the main side effect associated with dietary interactions of MAOIs?

<p>Hypertensive crisis (D)</p> Signup and view all the answers

Which antidepressant medication should be considered for a patient with primarily low energy and anhedonia?

<p>Venlafaxine (B)</p> Signup and view all the answers

What is the primary concern when combining certain foods with MAOIs?

<p>Hypertensive crisis (D)</p> Signup and view all the answers

Which strategy involves adding a second antidepressant to initial therapy after 4 to 8 weeks if there is a partial response?

<p>Augmentation therapy (D)</p> Signup and view all the answers

What is the main side effect profile consideration when selecting an antidepressant for patients with low energy and anhedonia?

<p>Sedation and insomnia (C)</p> Signup and view all the answers

Why are tricyclic antidepressants not preferable for patients with suicidal ideation or past suicide attempts?

<p>They have a risk of overdose (A)</p> Signup and view all the answers

Which food item should patients definitely avoid when taking MAOIs?

<p>'Definitely avoid': Aged cheeses (C)</p> Signup and view all the answers

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