Effects of Autonomic Drugs on Blood Pressure and Heart Rate
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Questions and Answers

What is the primary effect of noradrenaline on blood pressure?

  • It causes a decrease in blood pressure due to stimulation of β2 receptors
  • It causes an increase in blood pressure due to stimulation of α1 receptors (correct)
  • It has no effect on blood pressure
  • It causes a decrease in blood pressure due to stimulation of β1 receptors

What is the effect of noradrenaline on heart rate?

  • It has no effect on heart rate
  • It causes a decrease in heart rate due to stimulation of β1 receptors
  • It causes a decrease in heart rate due to stimulation of β2 receptors
  • It causes an increase in heart rate due to stimulation of β1 receptors (correct)

What is the effect of prazosin on the action of noradrenaline on blood pressure?

  • It abolishes the effect of noradrenaline on blood pressure (correct)
  • It enhances the effect of noradrenaline on blood pressure
  • It has no effect on the action of noradrenaline on blood pressure
  • It reverses the effect of noradrenaline on blood pressure

What type of receptor is isoprenaline selective for?

<p>Non-selective β-agonist (A)</p> Signup and view all the answers

What is the effect of isoprenaline on heart rate before administering propranolol?

<p>Increase in heart rate (A)</p> Signup and view all the answers

What is the effect of noradrenaline on heart rate, considering the reflex response?

<p>It causes a decrease in heart rate (A)</p> Signup and view all the answers

What is the primary mechanism of action of isoprenaline?

<p>It stimulates β1 and β2 receptors (D)</p> Signup and view all the answers

What is the primary function of propranolol in the experiment?

<p>Blocking β receptors (C)</p> Signup and view all the answers

What is the effect of isoprenaline on blood pressure before administering propranolol?

<p>Decrease in blood pressure (C)</p> Signup and view all the answers

What is the mechanism of action of adrenaline (epinephrine)?

<p>Direct binding to all types of adrenergic receptors (D)</p> Signup and view all the answers

What is the purpose of administering prazosin in the experiment with adrenaline?

<p>To block α1 receptors (B)</p> Signup and view all the answers

What is the effect of isoprenaline on blood pressure and heart rate after administering propranolol?

<p>No change in blood pressure and heart rate (A)</p> Signup and view all the answers

What is the effect of a large dose of adrenaline on blood pressure after administering prazosin?

<p>It decreases blood pressure due to the stimulation of β2 receptors. (C)</p> Signup and view all the answers

What is the reason for the increase in heart rate after administering a large dose of adrenaline after prazosin?

<p>Stimulation of β1 receptors. (B)</p> Signup and view all the answers

What is the effect of propranolol on the heart rate?

<p>It decreases heart rate due to the blockade of β1 receptors. (D)</p> Signup and view all the answers

What is the response of blood pressure to a large dose of adrenaline after administering propranolol?

<p>It increases blood pressure due to the stimulation of α1 receptors. (B)</p> Signup and view all the answers

Why is there no biphasic response of adrenaline after administering prazosin?

<p>Because prazosin blocks only α1 receptors. (A)</p> Signup and view all the answers

What is the purpose of administering propranolol before administering adrenaline in the experiment?

<p>To block β1 receptors and study their effect on heart rate. (A)</p> Signup and view all the answers

Flashcards

Noradrenaline's effect on blood pressure

Increases blood pressure by stimulating α1 receptors.

Noradrenaline's effect on heart rate

Increases heart rate by stimulating β1 receptors.

Prazosin's effect on noradrenaline-blood pressure

Blocks noradrenaline's effect on blood pressure, essentially abolishing it.

Isoprenaline receptor selectivity

Isoprenaline is a non-selective β-agonist, meaning it affects both β1 and β2 receptors.

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Isoprenaline's effect on heart rate (before propranolol)

Increases heart rate.

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Noradrenaline's effect on heart rate (reflex)

Decreases heart rate due to a reflex response.

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Isoprenaline's mechanism of action

Stimulates β1 and β2 receptors.

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Propranolol's function

Blocks β receptors.

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Isoprenaline's effect on blood pressure (before propranolol)

Decreases blood pressure.

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Adrenaline (Epinephrine) mechanism

Directly binds to all types of adrenergic receptors.

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Prazosin's purpose with adrenaline

Blocks α1 receptors, affecting adrenaline's action.

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Isoprenaline's effect on BP/HR (after propranolol)

No change in blood pressure or heart rate.

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High adrenaline +prazosin effect on BP

Decreases blood pressure due to β2 stimulation.

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High adrenaline after prazosin - HR increase reason

Stimulation of β1 receptors.

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Propranolol's effect on heart rate.

Decreases heart rate by blocking β1 receptors.

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High Adrenaline + Propranolol effect on blood pressure

Increases blood pressure due to α1 stimulation.

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No biphasic response of adrenaline (after prazosin), reason

Prazosin only blocks α1 receptors, preventing the biphasic response.

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Propranolol administration purpose (before adrenaline)

To block β1 receptors, allowing study of their effect on heart rate.

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