Effectiveness of NSAIDs in Gout Flare Prevention Quiz

Which of the following is the most effective for prophylaxis of gout flares during the initiation of urate-lowering therapy?

Combination of naproxen and colchicine

Placebo

Colchicine 0.5 - 1.0 mg/day

Naproxen (correct)

What percentage of subjects randomized to colchicine completed 8 weeks without a gout flare in the randomized controlled trial comparing naproxen and colchicine?

21% (correct)

50%

25%

36%

What was the primary finding of the double-blind randomized controlled trial that evaluated colchicine for gout flare prevention during the initiation of allopurinol?

Colchicine was more effective than placebo, with 25% of subjects in the colchicine group having a gout flare over 16 weeks. (correct)

Colchicine was less effective than placebo, with 75% of subjects in the colchicine group having a gout flare over 16 weeks.

There was no difference in efficacy between colchicine and placebo for preventing gout flares.

The trial was stopped early due to safety concerns with colchicine.

What is the recommended dose range for colchicine used in published studies for prophylaxis of gout flares during the initiation of urate-lowering therapy?

0.5 - 1.0 mg/day Signup and view all the answers

Which of the following is a potential concern with the use of colchicine for prophylaxis of gout flares?

Colchicine can interact with several medications commonly used in older patients with gout. Signup and view all the answers

What is the optimal duration of prophylaxis with NSAIDs or colchicine during the initiation of urate-lowering therapy?

The optimal duration is not certain according to the text. Signup and view all the answers

Which of the following is NOT a reason for using prophylactic therapy during the initiation of urate-lowering therapy (ULT) for gout?

To increase the dose of ULT more quickly to reach the target serum urate level Signup and view all the answers

Which of the following is the recommended duration for providing prophylactic therapy when initiating ULT for gout?

At least 6 months Signup and view all the answers

What is the recommended lower limit of the colchicine dosing range for prophylaxis of acute gout in patients without a history of chronic liver disease or dialysis?

0.6 mg daily Signup and view all the answers

Which of the following statements about the use of NSAIDs for gout prophylaxis is correct?

The specific choice of NSAID does not matter, as there is no evidence to show superiority of one NSAID over another for gout prophylaxis Signup and view all the answers

What is the main reason why dose adjustment of urate-lowering therapy (ULT) is crucial in managing gout treatment?

To quickly reach the target serum urate level and minimize the risk of gout flares Signup and view all the answers

Which of the following is a potential disadvantage of using corticosteroids for acute gout flares?

Corticosteroids may be contraindicated in some patients, especially the elderly with comorbidities and multiple medications Signup and view all the answers

Which of the following is NOT a potential reason why a gout flare may occur during the initiation of urate-lowering therapy (ULT)?

An increase in the dose of colchicine or NSAID being used for prophylaxis Signup and view all the answers

What is the recommended approach for preventing recurrent gout flares during urate-lowering therapy (ULT)?

Using low-dose colchicine or prednisone instead of increasing NSAID dose Signup and view all the answers

What is the rationale behind the recommendation to titrate the dose of allopurinol gradually when initiating urate-lowering therapy (ULT) for gout?

To minimize the risk of gout flares as the uric acid level falls Signup and view all the answers