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Chronic Gout Management

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Questions and Answers

What is the aim of chronic gout management?

To promote joint damage

To accelerate acute flares

To maintain the 'intercritical' phase (correct)

To increase tophi formation

How is joint damage primarily caused in chronic gout?

By excessive synovial fluid production

By immune system malfunction

Due to bacteria invasion

Through granuloma formation or crystalline deposition (correct)

What role does urate-lowering therapy (ULT) play in treating gout?

It increases uric acid levels in the body

It reduces the body's uric acid levels (correct)

It induces tophi formation

It promotes acute flares

Which medication is recommended for severe chronic gout that does not respond to other therapies?

Pegloticase Signup and view all the answers

What process does pegloticase perform in the body?

Breaks down uric acid to allantoin Signup and view all the answers

Why might it be debated whether 'intercritical' gout should be treated more aggressively?

'Intercritical' gout can still cause joint destruction without attacks Signup and view all the answers

What is the primary excretion route of Febuxostat?

Urine Signup and view all the answers

Which drug is rapidly metabolized to oxipurinol, its active form?

Allopurinol Signup and view all the answers

What do Xanthine Oxidase Inhibitors (XOIs) primarily target in gout treatment?

Xanthine oxidase activity Signup and view all the answers

Which condition is a contraindication for Uricosuric Agents?

Conditions increasing uric acid production or decreasing kidney function Signup and view all the answers

What is the unique feature of Pegloticase among ULT agents?

Intravenous administration and recombinant polyethylene glycolated Uch-A specific enzyme conjugate Signup and view all the answers

Why has the clinical use of uricosuric agents diminished over time?

's potential risks and limitations have become more evident Signup and view all the answers