Ecstasy and Oral Health Effects
47 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary route of elimination for MDMA?

  • Sweat
  • Fecal excretion
  • Respiratory
  • Urinary excretion (correct)
  • What enzyme primarily metabolizes MDMA?

  • Monoamine oxidase
  • Catechol-O-methyltransferase
  • Acetylcholinesterase
  • Cytochrome P450 (correct)
  • Which of these is NOT a commonly used name for MDMA?

  • E
  • Love Drug
  • Speed (correct)
  • XTC
  • Which of the following is NOT a systemic effect of MDMA use?

    <p>Hallucinations (A)</p> Signup and view all the answers

    What is the chemical structure of MDMA?

    <p>3,4-methylenedioxymethamphetamine (D)</p> Signup and view all the answers

    What is MDMA's classification under the 1971 Misuse of Drugs Act?

    <p>Class A (D)</p> Signup and view all the answers

    What is the primary reason MDMA was first synthesized?

    <p>Chemical warfare (C)</p> Signup and view all the answers

    What is the most common way to consume MDMA?

    <p>Oral (C)</p> Signup and view all the answers

    What is the medication being discussed, that is easily obtainable, and potentially fashionable?

    <p>Stimulant (A)</p> Signup and view all the answers

    What is the name of the effect that resembles a tyramine reaction?

    <p>Dependence syndrome (B)</p> Signup and view all the answers

    Which of these is NOT a potential cardiovascular complication of this medication?

    <p>Slowed Heart Rate (A)</p> Signup and view all the answers

    Which of the following is a potential neurological effect of this medication?

    <p>Loss of Coordination (B)</p> Signup and view all the answers

    Which of these metabolic effects could be caused by this medication?

    <p>Low Blood Sugar (A)</p> Signup and view all the answers

    Which of the following is NOT a stated potential gastrointestinal effect of this medication?

    <p>Constipation (C)</p> Signup and view all the answers

    Which of these can be a side effect of this drug?

    <p>Hallucinations (C)</p> Signup and view all the answers

    Which of the following complications is NOT mentioned as potentially being caused by the medication?

    <p>Heart Valve Problems (C)</p> Signup and view all the answers

    What was the patient's primary complaint?

    <p>Swelling in the mouth (D)</p> Signup and view all the answers

    What type of drug was the patient suspected of using?

    <p>MDMA (C)</p> Signup and view all the answers

    What was the primary finding on the upper anterior occlusal radiograph?

    <p>Mild blunting of the roots of the teeth (B)</p> Signup and view all the answers

    What was the diagnosis made for the patient?

    <p>Local drug-induced necrotising gingivitis (B)</p> Signup and view all the answers

    What was the primary treatment for the patient's condition?

    <p>Cessation of MDMA use and oral hygiene education (A)</p> Signup and view all the answers

    What was the primary reason for the use of fluoride varnish on exposed roots?

    <p>To reduce dentin sensitivity (B)</p> Signup and view all the answers

    What was the significance of the orthodontic retainer used in this case?

    <p>To support the mobile teeth (B)</p> Signup and view all the answers

    What was the outcome of the treatment for the patient at the 4-month follow-up?

    <p>The patient's condition had improved significantly (C)</p> Signup and view all the answers

    What type of dental treatment had the patient recently completed?

    <p>Orthodontic treatment (B)</p> Signup and view all the answers

    What recreational drug did the patient disclose using?

    <p>Ecstasy (A)</p> Signup and view all the answers

    What is the primary mechanism by which SSRIs may worsen the effects of Ecstasy?

    <p>SSRIs inhibit the breakdown of MDMA, prolonging its effects and potential for harm. (C)</p> Signup and view all the answers

    What was the patient's oral hygiene status described as?

    <p>Good (B)</p> Signup and view all the answers

    What is a common acute oral manifestation of MDMA use?

    <p>Jaw clenching (C)</p> Signup and view all the answers

    What was a possible contributing factor to the patient's lip swelling?

    <p>Prolonged contact with the drug in the labial vestibule (D)</p> Signup and view all the answers

    What periodontitis was found in the patient's oral examination?

    <p>Localized periodontitis (D)</p> Signup and view all the answers

    Which of the following factors contributes to tooth surface loss (TSL) in MDMA users?

    <p>Prolonged tooth clenching (B)</p> Signup and view all the answers

    What aspect of the patient's case highlights the need for suspicion of drug abuse?

    <p>The patient's reported drug use (B)</p> Signup and view all the answers

    What is the primary reason behind the elevation of AST and GGT levels in the case study described?

    <p>Possible liver damage associated with MDMA use (D)</p> Signup and view all the answers

    Why is MDMA described as potentially dangerous despite being widely accepted?

    <p>It can have serious side effects that are not related to dose or frequency of use. (A)</p> Signup and view all the answers

    What is the likely reason for the increased white blood cell count (WCC), particularly eosinophils, in the case study?

    <p>Infection associated with dental abscess (A)</p> Signup and view all the answers

    Why might drug abusers require higher doses of local anesthetics for dental treatment?

    <p>Tolerance developed from long-term use of substances (D)</p> Signup and view all the answers

    Which of the following oral manifestations of MDMA use can lead to tooth decay?

    <p>Thirst and consumption of sugary drinks (D)</p> Signup and view all the answers

    What is the enzyme involved in the metabolism of MDMA that is inhibited by SSRIs?

    <p>CYP2D6 (B)</p> Signup and view all the answers

    What is a common oral manifestation associated with MDMA use?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the primary reason for the gingival damage associated with MDMA use?

    <p>Excessive toothbrushing during intoxication (D)</p> Signup and view all the answers

    Which of the following is NOT mentioned as a possible explanation for the gingival lesions observed in the patient described in the text?

    <p>Local drug reaction due to application of MDMA (B)</p> Signup and view all the answers

    What is the primary reason MDMA is typically ingested orally?

    <p>It is the most convenient method of administration (D)</p> Signup and view all the answers

    Which of the following drugs, when used in a similar way as MDMA, has been linked to oral lesions?

    <p>Cocaine (A)</p> Signup and view all the answers

    How does the text describe the presentation of necrotizing gingivitis in the patient?

    <p>With erythema and ulceration of the gingiva (A)</p> Signup and view all the answers

    What is the primary reason for the patient's gingival lesions being initially attributed to MDMA?

    <p>The patient's self-reported application of MDMA to the gums (D)</p> Signup and view all the answers

    Which of the following is NOT a possible reason why the patient's lesions were not initially attributed to cocaine use?

    <p>Cocaine is not known to cause necrotizing gingivitis (C)</p> Signup and view all the answers

    Flashcards

    MDMA

    Methylenedioxymethamphetamine, also known as Ecstasy, a recreational drug.

    Systemic effects of MDMA

    Various health impacts affecting the entire body, potentially including death.

    Tooth clenching

    Involuntary grinding or clenching of teeth often due to MDMA use.

    Periodontitis

    Inflammation and infection of the periodontal tissues often linked to drug use.

    Signup and view all the flashcards

    Oral implications of MDMA

    Effects of MDMA on the mouth including tooth loss and ulcers.

    Signup and view all the flashcards

    Psychoactive properties

    Effects on mood, perception, and cognitive functions from MDMA.

    Signup and view all the flashcards

    MDMA metabolism

    The breakdown of MDMA in the body primarily in the liver, often through cytochrome P450.

    Signup and view all the flashcards

    Long-term effects of MDMA

    Potential chronic health issues resulting from repeated use, such as addiction.

    Signup and view all the flashcards

    Sympathomimetic

    A substance that mimics the effects of the sympathetic nervous system, often leading to increased alertness and euphoria.

    Signup and view all the flashcards

    Effects of Sympathomimetics

    Agitation, delirium, panic disorders, hallucinations, and even suicidal ideation can occur with sympathomimetics.

    Signup and view all the flashcards

    Neurological Sequelae

    Physical effects on the nervous system, such as seizures and tremors, caused by drug use.

    Signup and view all the flashcards

    Cardiovascular Risks

    Potential heart-related issues including tachyarrhythmias and myocardial ischaemia due to drug intake.

    Signup and view all the flashcards

    Respiratory Complications

    Breathing-related issues such as pulmonary hypertension and edema linked to stimulant use.

    Signup and view all the flashcards

    Hepatorenal Effects

    Kidney and liver complications including renal failure and jaundice, induced by substance use.

    Signup and view all the flashcards

    Metabolic Issues

    Alterations in body chemistry leading to acidosis, hypo/hyperglycemia as a result of stimulants.

    Signup and view all the flashcards

    Gastrointestinal Reactions

    Digestive side effects including nausea, vomiting, and ischaemic colitis from drug usage.

    Signup and view all the flashcards

    SSRI

    Selective serotonin reuptake inhibitor, a class of antidepressants.

    Signup and view all the flashcards

    CYP2D6

    An enzyme that metabolizes various drugs, including MDMA.

    Signup and view all the flashcards

    Bruxism

    Involuntary teeth grinding or jaw clenching, commonly seen with MDMA use.

    Signup and view all the flashcards

    Dry Mouth

    A common oral effect of MDMA use, leading to discomfort.

    Signup and view all the flashcards

    Tooth Surface Loss (TSL)

    Loss of tooth structure, often caused by acid consumption and bruxism.

    Signup and view all the flashcards

    Acute Dentoalveolar Abscess

    A painful dental condition resulting from infection, possibly worsened by MDMA.

    Signup and view all the flashcards

    Eosinophils

    A type of white blood cell that may increase during allergic reactions or infections.

    Signup and view all the flashcards

    Elevated Liver Enzymes

    Increased levels of liver enzymes indicating potential liver stress or damage, often checked in drug use.

    Signup and view all the flashcards

    Ischaemic vasoconstriction

    Vasoconstriction caused by reduced blood flow due to an ischemic event, often linked to drug use.

    Signup and view all the flashcards

    Cervical abrasions

    Wearing away of the tooth enamel at the neck of the tooth, often due to excessive brushing or drug interactions.

    Signup and view all the flashcards

    Necrotising gingivitis

    Severe gum disease characterized by ulceration, swelling, and the death of gum tissue, potentially induced by drug use.

    Signup and view all the flashcards

    Gingival ulceration

    Formation of ulcers in the gum tissue, often associated with irritants like drugs.

    Signup and view all the flashcards

    Oral mucosa reaction

    Local effects occurring in the mouth, especially after drug application or irritation.

    Signup and view all the flashcards

    Local drug reaction

    A reaction that occurs in a specific area of the body due to the application of drugs, rather than systemic effects.

    Signup and view all the flashcards

    Cocaine-related injuries

    Damage to oral tissues potentially resulting from the use of cocaine, such as lacerations or abrasions.

    Signup and view all the flashcards

    MDMA and oral health

    The effects of MDMA on dental and oral health, including possible tissue damage and dental erosion.

    Signup and view all the flashcards

    General Malaise

    A state of general discomfort or unease, often indicative of an underlying condition.

    Signup and view all the flashcards

    Pyrexia

    An elevated body temperature or fever, often a sign of illness.

    Signup and view all the flashcards

    MDMA (Ecstasy)

    A recreational drug known for its stimulating and empathogenic effects, potentially leading to adverse side effects.

    Signup and view all the flashcards

    periodontal pockets

    Spaces that form between the teeth and gums due to gum disease, indicating periodontal destruction.

    Signup and view all the flashcards

    Salivary flow

    The production and secretion of saliva in the mouth, crucial for oral health.

    Signup and view all the flashcards

    Localised defect in alveolar gingiva

    A specific area of loss or damage in the gum tissue or bone supporting the teeth.

    Signup and view all the flashcards

    Recreational drug use

    The consumption of substances for pleasure rather than for medical reasons.

    Signup and view all the flashcards

    Symptoms of drug use

    Signs that may include malaise, fever, or unusual changes in health due to substance abuse.

    Signup and view all the flashcards

    Viridans Streptococci

    A group of streptococci bacteria commonly found in the oral cavity.

    Signup and view all the flashcards

    TMJ Arthromyalgia

    Pain in the temporomandibular joint and surrounding muscles.

    Signup and view all the flashcards

    Dental Attrition

    Wearing away of tooth enamel due to grinding or clenching.

    Signup and view all the flashcards

    Xerostomia

    Dry mouth condition often leading to discomfort and oral issues.

    Signup and view all the flashcards

    Mucosal Ulceration

    Sores that develop on the mucous membranes of the mouth.

    Signup and view all the flashcards

    Cessation of MDMA Use

    Stopping the intake of MDMA, which may lead to recovery from complications.

    Signup and view all the flashcards

    Sub-gingival Debridement

    Cleaning below the gum line to remove plaque and tartar.

    Signup and view all the flashcards

    Fluoride Application

    Topical treatment to prevent dental sensitivity and decay.

    Signup and view all the flashcards

    Study Notes

    • Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, is a recreational drug with oral and systemic effects.

    • MDMA use has been linked to a previously unreported oral manifestation: periodontitis.

    • Systemic effects of MDMA use include:

      • Psychiatric: agitation, delirium, panic, paranoia, depression, psychosis, suicidal thoughts.
      • Neurological: ataxia, seizures, tremor, tics, nystagmus, cerebral hemorrhage.
      • Cardiovascular: tachycardia, hypertension, myocardial ischemia/infarction, ventricular ectopy.
      • Respiratory: pulmonary hypertension and edema.
      • Hepatorenal: renal failure, urinary retention, myoglobinuria, jaundice, hepatitis, hepatic failure.
      • Metabolic: metabolic acidosis, hyponatremia, hypoglycemia, rhabdomyolysis, hyperthermia.
      • Gastrointestinal: nausea, vomiting, anorexia, diarrhea, ischemic colitis.
      • Other: disseminated intravascular coagulation (DIC), vasculitis, sexual dysfunction, serotonin syndrome, aplastic anemia, death.
    • Oral effects of MDMA include

      • Bruxism and tooth clenching
      • Temporomandibular joint (TMJ) arthromyalgia
      • Dental attrition
      • Xerostomia (dry mouth)
      • Mucosal ulceration
      • Periodontitis
    • A 15-year-old boy presented with upper lip swelling, malaise, and fever.

      • He had just finished orthodontic treatment and had good oral hygiene.
      • He reported using MDMA recreationally the day prior.
      • MDMA was found in the labial vestibule adjacent to periodontal destruction.
    • A mucosal fenestration defect was found on the upper lip, with exposed alveolar bone and roots.

    • Mild root blunting and no significant bone loss were observed on radiographs.

    • White blood cell count was elevated with an increase in eosinophils.

    • Erythrocyte sedimentation rate (ESR) and liver enzymes were elevated.

    • The culture of the fluid from the abscess showed normal oral flora.

    • Topical application of MDMA was suspected as the cause.

    • Treatment included:

      • Oral antibiotics (Penicillin V and Metronidazole)
      • Oral hygiene instruction, scaling, and polishing
      • Scaling and sub-gingival debridement
      • Fluoride application to exposed roots
      • Orthodontic retainer for mobile teeth
    • The mucosal ulcer healed in one week, and the patient was discharged for routine periodontal care after 4 months.

    • MDMA is frequently used, though it can be dangerous.

    • Dentists should be aware of potential complications of MDMA use.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Description

    Explore the oral manifestations of ecstasy, specifically focusing on periodontitis and mucosal ulceration. This quiz delves into the systemic effects of MDMA usage, highlighting the psychiatric, neurological, cardiovascular, respiratory, hepatological, metabolic, gastrointestinal, and other complications associated with this recreational drug. Test your knowledge on how ecstasy impacts overall health.

    More Like This

    Use Quizgecko on...
    Browser
    Browser