MPP Block 4 Practice: Reproductive System

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Questions and Answers

Which of the following best describes GnRH secretion?

Pulsatile and highly synchronized (correct)
Continuous and steady
Only occurs during ovulation
Random and unpredictable

What is the primary function of LH in theca cells?

activates aromatase enzyme
upregulates production of secreted androgens (correct)
inhibits cholesterol synthesis
converts estradiol to testosterone

What is the primary reason granulosa cells rely on theca cells for sex steroid synthesis?

granulosa cells cannot produce cAMP
granulosa cells cannot synthesize cholesterol
granulosa cells don't contain enough 17-alpha-hydroxylase (correct)
granulosa cells lack LH receptors

What is the role of activins in the female reproductive system?

They stimulate FSH secretion and upregulate FSH receptors (A) Signup and view all the answers

Which of the following is the most potent estrogen?

Estradiol (A) Signup and view all the answers

How does estrogen feedback change during the midcycle of the menstrual cycle?

It shifts from negative to positive feedback (D) Signup and view all the answers

What happens to LH and FSH just prior to ovulation?

Both hormones surge (C) Signup and view all the answers

What is the approximate duration of the menstrual cycle?

28 days (B) Signup and view all the answers

Which cell type contains FSH receptors that activate aromatase?

Granulosa cells (C) Signup and view all the answers

What is the relationship between inhibins and FSH?

Inhibins decrease FSH secretion and provide negative feedback (C) Signup and view all the answers

How does progesterone affect internal body temperature?

It increases internal temperature (C) Signup and view all the answers

What is the approximate half-life of progesterone in the body?

5 minutes (D) Signup and view all the answers

Which of the following describes the two distinct cycles that make up the menstrual cycle?

Ovarian cycle and endometrial cycle (C) Signup and view all the answers

What happens to estrogen levels during the midcylce of the menstrual cycle?

They become elevated (D) Signup and view all the answers

What type of receptor family do LH receptors belong to?

G protein-couple receptors (GPCR) (B) Signup and view all the answers

What enzyme is activated in theca cells to facilitate the conversion of cholesterol to pregnenolone?

side-chain cleavage enzyme complex (A) Signup and view all the answers

What is the primary function of progesterone in the female reproductive system?

Initiating and maintaining pregnancy (B) Signup and view all the answers

What estrogen receptor is primarily found in reproductive organs?

ERα (B) Signup and view all the answers

Which second messenger system is primarily activated by LH receptors in theca cells?

Adenylyl cyclase-cAMP pathway (B) Signup and view all the answers

What is the effect of progesterone on endometrial growth?

Decreases (B) Signup and view all the answers

Flashcards

GnRH secretion

Pulsatile and highly synchronized release of Gonadotropin-releasing hormone.

Primary function of LH in theca cells

Stimulates the production of androgens in the ovaries.