Early Human Development - Dr. Hilary Sheppard

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What is the main purpose of the ex vivo gene therapy strategy discussed in the overview?

To perform organogenesis after gastrulation

To achieve 100% epidermal stem cell retention

To create three germ layers during gastrulation

To achieve approximately 5% epidermal stem cell retention (correct)

What is the significance of the DAPI, Collagen 7, and FOX-M1 markers in the edited skin samples shown in the image?

They demonstrate the co-expression of stem cell and structural proteins in the edited skin (correct)

They indicate the presence of differentiated cells in the skin samples

They confirm that the skin samples have undergone successful organogenesis

They show the different germ layers present in the skin samples after gastrulation

What is the key purpose of using stem cells in the clinical utility of this gene therapy strategy?

To replace differentiated cells and enable long-lasting skin grafts (correct)

To create three germ layers during gastrulation for organogenesis

To perform cleavage and blastula formation during embryonic development

To enable growth, repair, and renewal of the skin tissue

What is the significance of the fertilization process mentioned in the 'How does it all start?' section?

It is the process that results in the formation of the 2n zygote, which then undergoes cleavage Signup and view all the answers

What is the connection between the BIOSCI201 and BIOSCI356 courses mentioned at the end of the text?

BIOSCI201 and BIOSCI356 are elective courses that students can take to learn more about the content covered in the overview Signup and view all the answers

Which of the following accurately describes the process of gastrulation?

It is the process that generates the three primary germ layers: ectoderm, mesoderm, and endoderm. Signup and view all the answers

Which of the following is NOT a function of the trophoblast?

Generating the three primary germ layers during gastrulation. Signup and view all the answers

What is the primary function of stem cells during embryogenesis?

To provide a source of undifferentiated cells that can give rise to various cell types and tissues. Signup and view all the answers

Which of the following sequences accurately represents the early stages of embryonic development?

Fertilization, cleavage, formation of the morula and blastocyst, implantation, gastrulation. Signup and view all the answers

According to the Second Law of Thermodynamics, what happens to entropy over time?

Entropy increases. Signup and view all the answers

Which of the following statements accurately describes the process of patterning during embryogenesis?

It is the process by which cells acquire specific identities and positions in the developing embryo. Signup and view all the answers

What is the primary function of stem cells in the skin according to the text?

Constant renewal of the skin Signup and view all the answers

Which of the following best describes the stem cell hierarchy shown in Fig. 1?

Stem cells can differentiate into multiple cell types, but their potential decreases as they become more specialized Signup and view all the answers

What is the primary function of the primitive streak during embryonic development?

To establish the three primary germ layers (ectoderm, mesoderm, endoderm) Signup and view all the answers

Which of the following is a key characteristic of differentiated cells as described in the text?

Differentiated cells have limited division potential Signup and view all the answers

What is the defining characteristic of a stem cell?

The ability to divide and self-renew while also generating differentiated daughter cells Signup and view all the answers

What is the primary function of the yolk sac during embryonic development?

To provide nutrients and oxygen to the developing embryo Signup and view all the answers

Early Human Development - Dr. Hilary Sheppard

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