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DUO-E Clinical Trial: Treatment and Randomization

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DUO-E Clinical Trial: Treatment and Randomization

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Questions and Answers

What is the primary objective of the DUO-E clinical trial?

To compare the efficacy of durvalumab and olaparib in patients with newly diagnosed advanced or recurrent EC

To assess the safety profile of durvalumab in patients with EC

To evaluate the efficacy and safety of first-line durvalumab + platinum-based chemotherapy followed by maintenance durvalumab ± olaparib (correct)

To investigate the effects of platinum-based chemotherapy on patients with EC

What is the dual primary endpoint of the DUO-E clinical trial?

Overall survival (OS) and quality of life

Investigator-assessed progression-free survival (PFS) for durvalumab only arm vs placebo arm, and durvalumab + olaparib arm vs placebo arm (correct)

Time to progression (TTP) and treatment-related adverse events

Objective response rate (ORR) and duration of response

What is the treatment regimen being evaluated in the DUO-E clinical trial?

First-line platinum-based chemotherapy followed by maintenance durvalumab ± olaparib (correct)

First-line carboplatin/paclitaxel followed by maintenance durvalumab

First-line durvalumab + olaparib followed by maintenance paclitaxel

First-line durvalumab + olaparib followed by maintenance carboplatin/paclitaxel

What is the patient population being studied in the DUO-E clinical trial?

Patients with newly diagnosed advanced or recurrent EC Signup and view all the answers

What is the role of olaparib in the DUO-E clinical trial?

As a maintenance therapy in combination with durvalumab Signup and view all the answers

What is the purpose of the investigator-assessed progression-free survival (PFS) endpoint in the DUO-E clinical trial?

To compare the efficacy of durvalumab with and without olaparib Signup and view all the answers

What is the significance of the placebo arm in the DUO-E clinical trial?

It serves as a comparator arm to evaluate the efficacy of durvalumab + olaparib Signup and view all the answers

What is the role of carboplatin/paclitaxel in the DUO-E clinical trial?

As a platinum-based chemotherapy agent in combination with durvalumab Signup and view all the answers

What is the significance of the maintenance phase in the DUO-E clinical trial?

It evaluates the efficacy of durvalumab ± olaparib after initial treatment with platinum-based chemotherapy Signup and view all the answers

What is the scope of the DUO-E clinical trial?

A phase III trial evaluating the efficacy and safety of durvalumab + platinum-based chemotherapy followed by maintenance durvalumab ± olaparib in patients with newly diagnosed advanced or recurrent EC Signup and view all the answers