Drugs for Bronchial Asthma

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Questions and Answers

What is the peak effect time frame for administering ICS?

8-10 days

Over 10 days

4-7 days (correct)

1-3 days

Which of the following is NOT an effect of ICS?

Suppress bronchial inflammation

Increase the peak expiratory flow rate

Prevent episodes of acute asthma

Completely eliminate asthma symptoms (correct)

What is the maximum recommended dose of ICS?

400µg QID (correct)

800µg QID

200µg QID

600µg QID

Which adverse effect is common with the use of ICS?

Dysphonia Signup and view all the answers

What class of drugs includes Budesonide?

Non-halogenated glucocorticoids Signup and view all the answers

Which substance is effective in treating or preventing oral candidiasis related to ICS use?

Nystatin Signup and view all the answers

Which ICS is contraindicated in the presence of nasal infection?

Budesonide Signup and view all the answers

What is a characteristic of Fluticasone propionate?

It has negligible oral bioavailability Signup and view all the answers

What is the primary purpose of inhalational corticosteroids (ICS) in asthma treatment?

To prevent bronchial remodeling Signup and view all the answers

Why are inhalational corticosteroids (ICS) not typically used in mild episodic asthma patients?

Their effectiveness is minimized in mild cases Signup and view all the answers

Which statement about the pharmacokinetics of inhalational corticosteroids (ICS) is true?

They have significant first pass metabolism and poor absorption Signup and view all the answers

Which of these is NOT a characteristic of inhalational corticosteroids (ICS)?

Immediate relief of symptoms Signup and view all the answers

What is the role of sympathomimetic drugs in asthma management?

They are used to provide immediate bronchial dilation Signup and view all the answers

Which of the following is NOT a type of drug mentioned for treating bronchial asthma?

Antihistamines Signup and view all the answers

What is a common misconception about inhalational corticosteroids (ICS)?

They are unnecessary for all asthma patients Signup and view all the answers

Which option best describes the profile of inhalational corticosteroids (ICS)?

Glucocorticoids with high topical and low systemic activity Signup and view all the answers

Study Notes

Drugs for Bronchial Asthma

Inhalational corticosteroids (ICS) are effective in preventing bronchial remodeling.
They have poor absorption and undergo significant first-pass metabolism.
ICS are not necessarily used in mild and episodic asthma patients.
Peak effect of ICS is seen after 4-7 days of administration and persists for a few weeks after discontinuation.
Initial dosage is 100-200µg twice daily; adjust dosage upward every 3-5 days; maximum dose is 400µg four times daily.
ICS are generally safe during pregnancy.

Functions of ICS:

Suppress bronchial inflammation
Increase peak expiratory flow rate
Reduce the necessity for β2-agonist inhalations
Prevent episodes of acute asthma

Adverse Drug Effects of ICS:

Hoarseness of voice
Dysphonia
Sore throat
Symptomatic or asymptomatic oropharyngeal candidiasis
Dose greater than 600µg/day can cause mood changes, osteoporosis, growth retardation in children, early cataracts, etc.

Reducing Adverse Drug Effects:

The usage of spacers helps minimize ADRs.
Gargling after every dose can also reduce ADRs.
Topical nystatin or clotrimazole can prevent or treat oral candidiasis.

Specific Drugs:

Beclomethasone dipropionate: Effective in treating perennial rhinitis
Budesonide: Non-halogenated glucocorticoid with a high topical-to-systemic activity ratio; preferred in severe cases; contraindicated in presence of nasal infection and ulcers
Fluticasone propionate: High potency, longer duration, negligible oral bioavailability; preferred in patients requiring higher doses
Flunisolide: Topical steroid for prophylaxis and treatment of seasonal and perennial rhinitis
Ciclesonide: A prodrug that releases the active moiety in the bronchial epithelium; oral bioavailability is negligible

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Description

Explore the role of inhalational corticosteroids in managing bronchial asthma. This quiz covers their effects, dosage regimens, benefits, adverse effects, and safety during pregnancy. Test your understanding of these important asthma medications.