Drugs Affecting Cardiovascular System
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Questions and Answers

What is the primary function of a diuretic?

  • To promote the retention of electrolytes
  • To decrease hydration levels in the body
  • To increase the production of urine (correct)
  • To stimulate the absorption of water
  • Which electrolyte is specifically mentioned as being excreted due to diuretic use?

  • Ca2+
  • Na+ (correct)
  • Mg2+
  • K+
  • What term describes the obstruction caused by a withdrawing group such as NO2?

  • Electrostatic repulsion
  • Hydrophilic interaction
  • Steric hindrance (correct)
  • Chemical stability
  • What happens to cAMP levels when platelet aggregation increases?

    <p>cAMP levels decrease</p> Signup and view all the answers

    Which of the following is a result of diuretic action?

    <p>Decreased blood pressure</p> Signup and view all the answers

    Which group is considered a withdrawing group that could influence steric hindrance?

    <p>NO2</p> Signup and view all the answers

    Which drug replaced ticlopidine to reduce the risk of neutropenia?

    <p>Clopidogrel</p> Signup and view all the answers

    How does an increase in cAMP affect platelet aggregation?

    <p>It inhibits platelet aggregation</p> Signup and view all the answers

    In the pathway described, what is the effect of decreased cAMP on vasodilatation?

    <p>Vasodilatation is diminished</p> Signup and view all the answers

    What is the result of reversing the described pathway involving platelets and cAMP?

    <p>Increased platelet aggregation and cAMP</p> Signup and view all the answers

    What effect does the substitution of a benzene ring by an electron-donating group (ED) have on anticancer activity?

    <p>It increases anticancer activity.</p> Signup and view all the answers

    How does the substitution of a benzene ring by an electron-withdrawing group (EWD) affect its anticancer activity?

    <p>It decreases anticancer activity.</p> Signup and view all the answers

    Which statement accurately reflects the influence of substituents on anticancer activity in the order of effectiveness?

    <p>ED on aromatic &gt; Aliphatic &gt; Aromatic &gt; EWD on aromatic</p> Signup and view all the answers

    Which scenario is likely to yield the highest anticancer activity?

    <p>A compound with ED substitution on a benzene ring.</p> Signup and view all the answers

    What is the general trend in the anticancer activity due to substituents on aromatic compounds?

    <p>ED enhances activity more than EWD decreases it.</p> Signup and view all the answers

    What is a primary use of the drug mentioned besides treating cancer?

    <p>Treating rheumatoid arthritis</p> Signup and view all the answers

    Which statement accurately describes a virus?

    <p>It is an obligatory intracellular parasite.</p> Signup and view all the answers

    What role do antiviral drugs play in relation to viruses?

    <p>They inhibit the replication of viruses.</p> Signup and view all the answers

    Which of the following best describes the interaction between a virus and a host cell?

    <p>The virus uses the host cell's machinery for its replication.</p> Signup and view all the answers

    What condition is a virus NOT responsible for treating with antiviral drugs?

    <p>Rheumatoid arthritis</p> Signup and view all the answers

    What effect do electron donating groups (ED gp) have on Nitrogen in the context of Aziridinium cation formation?

    <p>They stabilize and fix the lone pair of Nitrogen.</p> Signup and view all the answers

    How do electron donating groups influence anticancer activity?

    <p>By increasing Aziridinium cation formation.</p> Signup and view all the answers

    What is the primary role of lone pairs of Nitrogen in the context of Aziridinium cation stabilization?

    <p>They facilitate the bonding of Aziridinium.</p> Signup and view all the answers

    Which of the following best explains the relationship between electron donating groups and Aziridinium cations?

    <p>ED groups fixate lone pairs, enhancing cation formation.</p> Signup and view all the answers

    What consequence does the stabilization of Nitrogen's lone pair have on anticancer compounds?

    <p>It enhances the efficacy of anticancer activity.</p> Signup and view all the answers

    What role do M2 channels play in the virus's life cycle?

    <p>They allow the acidification of the virus.</p> Signup and view all the answers

    What happens when M2 inhibitors are applied?

    <p>The action of acidification is blocked.</p> Signup and view all the answers

    Which of the following is NOT a consequence of M2 channel activity?

    <p>Prevention of viral replication.</p> Signup and view all the answers

    Which statement accurately describes the function of M2 channels in a viral infection?

    <p>They allow protons to enter the virus.</p> Signup and view all the answers

    What is one immediate effect of blocking M2 channels in a viral context?

    <p>Impaired viral uncoating.</p> Signup and view all the answers

    Study Notes

    Drugs Affecting Cardiovascular System (CVS)

    • Blood pressure (hypertension) is the force of blood against artery walls as the heart pumps blood.
    • Hypertension occurs when the force is stronger than normal.
    • Normal blood pressure is systolic >140 mmHg and/or diastolic >90 mmHg.

    Anti-hypertensive Drugs

    • Subtype α1 (receptors):
      • Effect: Vasoconstriction (blood vessel constriction)
      • Organ: Peripheral blood vessels (arterioles)
    • Subtype α2 (receptors):
      • Effect: Decreases sympathetic outflow (reduces nerve signals)
      • Organ: Presynaptic neurons (CNS)
    • Subtype β1 (receptors):
      • Effect: Increases force and rate of contraction
      • Organ: Heart
    • Subtype β2 (receptors):
      • Effect: Bronchodilation (widening of bronchi)
      • Organ: Bronchi

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    Description

    This quiz covers the essential aspects of anti-hypertensive drugs, including their effects on various receptors and the cardiovascular system. Learn about the mechanisms of how these drugs work and their implications for managing hypertension. Test your knowledge on blood pressure and drugs affecting the heart and blood vessels.

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