Drugs Acting Against Parasitic Diseases - Pharm 451 Quiz
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Questions and Answers

What is the drug of choice for asymptomatic patients with Entamoeba histolytica?

  • Diloxanide Furoate (correct)
  • Ornidazole
  • Metronidazole
  • Tinidazole
  • Which drug group is considered the drugs of choice for both intestinal and systemic amoebiasis?

  • Thiabendazole
  • Mebendazole
  • Niclosamide
  • Nitroimidazoles (correct)
  • What is the essential group in drugs like Metronidazole and Tinidazole that is crucial for their activity?

  • 5-nitro group (correct)
  • Aromatic ring
  • Alkyl group
  • Amide group
  • Which drug interacts with DNA to cause a loss of helical structure, strand breakage, and inhibition of nucleic acid synthesis?

    <p>Metronidazole</p> Signup and view all the answers

    Which drug is similar to Metronidazole but has a longer duration of action?

    <p>Ornidazole</p> Signup and view all the answers

    What is the main mechanism of action of Nitroimidazoles against bacteria and protozoa?

    <p>Oxidative reactive species causing DNA damage</p> Signup and view all the answers

    What is the mechanism of action of Mebendazole?

    <p>Irreversibly blocking glucose uptake in susceptible helminths</p> Signup and view all the answers

    Which anthelmintic is primarily used for treating threadworms and roundworms by blocking the response of ascaris muscle to acetylcholine?

    <p>Mebendazole</p> Signup and view all the answers

    What is the active form of Albendazole in plasma after undergoing rapid and extensive first-pass metabolism?

    <p>Sulfoxide</p> Signup and view all the answers

    What enzyme does Thiabendazole inhibit?

    <p>Fumarate reductase</p> Signup and view all the answers

    Which anthelmintic causes phosphorylation in the mitochondria, interfering with vital life processes of the worm?

    <p>Niclosamide</p> Signup and view all the answers

    What is the mode of action of Pyrantel against susceptible helminths?

    <p>Inhibiting acetylcholinesterase</p> Signup and view all the answers

    Which anthelmintic is widely used in veterinary practice to control intestinal helminths in livestock?

    <p>Thiabendazole</p> Signup and view all the answers

    What is the broad-spectrum anthelmintic effective as a single-dose treatment for ascariasis and undergoes rapid first-pass metabolism?

    <p>Albendazole</p> Signup and view all the answers

    Which drug should not be used together with Piperazine due to potential interactions?

    <p>Pyrantel</p> Signup and view all the answers

    What is the primary function of Niclosamide in taeniacide treatment?

    <p>Induces phosphorylation in mitochondria</p> Signup and view all the answers

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