Drugs Acting Against Parasitic Diseases - Pharm 451 Quiz
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Questions and Answers

What is the drug of choice for asymptomatic patients with Entamoeba histolytica?

  • Diloxanide Furoate (correct)
  • Ornidazole
  • Metronidazole
  • Tinidazole

Which drug group is considered the drugs of choice for both intestinal and systemic amoebiasis?

  • Thiabendazole
  • Mebendazole
  • Niclosamide
  • Nitroimidazoles (correct)

What is the essential group in drugs like Metronidazole and Tinidazole that is crucial for their activity?

  • 5-nitro group (correct)
  • Aromatic ring
  • Alkyl group
  • Amide group

Which drug interacts with DNA to cause a loss of helical structure, strand breakage, and inhibition of nucleic acid synthesis?

<p>Metronidazole (B)</p> Signup and view all the answers

Which drug is similar to Metronidazole but has a longer duration of action?

<p>Ornidazole (B)</p> Signup and view all the answers

What is the main mechanism of action of Nitroimidazoles against bacteria and protozoa?

<p>Oxidative reactive species causing DNA damage (B)</p> Signup and view all the answers

What is the mechanism of action of Mebendazole?

<p>Irreversibly blocking glucose uptake in susceptible helminths (D)</p> Signup and view all the answers

Which anthelmintic is primarily used for treating threadworms and roundworms by blocking the response of ascaris muscle to acetylcholine?

<p>Mebendazole (A)</p> Signup and view all the answers

What is the active form of Albendazole in plasma after undergoing rapid and extensive first-pass metabolism?

<p>Sulfoxide (D)</p> Signup and view all the answers

What enzyme does Thiabendazole inhibit?

<p>Fumarate reductase (C)</p> Signup and view all the answers

Which anthelmintic causes phosphorylation in the mitochondria, interfering with vital life processes of the worm?

<p>Niclosamide (D)</p> Signup and view all the answers

What is the mode of action of Pyrantel against susceptible helminths?

<p>Inhibiting acetylcholinesterase (C)</p> Signup and view all the answers

Which anthelmintic is widely used in veterinary practice to control intestinal helminths in livestock?

<p>Thiabendazole (A)</p> Signup and view all the answers

What is the broad-spectrum anthelmintic effective as a single-dose treatment for ascariasis and undergoes rapid first-pass metabolism?

<p>Albendazole (D)</p> Signup and view all the answers

Which drug should not be used together with Piperazine due to potential interactions?

<p>Pyrantel (B)</p> Signup and view all the answers

What is the primary function of Niclosamide in taeniacide treatment?

<p>Induces phosphorylation in mitochondria (D)</p> Signup and view all the answers

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