Podcast
Questions and Answers
What is primarily responsible for drug tolerance?
What is primarily responsible for drug tolerance?
- Inhibition of neurotransmitter breakdown
- Decrease in neurotransmitter production
- Increased receptor sensitivity and number due to antagonist action
- Decreased receptor sensitivity and number due to agonist action (correct)
What effect do antagonists have on the neurotransmitter receptors?
What effect do antagonists have on the neurotransmitter receptors?
- Deplete neurotransmitter stores
- Stimulate neurotransmitter release
- Block specific receptors preventing normal neurotransmitter action (correct)
- Increase the neurotransmitter breakdown
Which process is linked to drug addiction as a result of antagonist use?
Which process is linked to drug addiction as a result of antagonist use?
- Increased neurotransmitter degradation
- Desensitization
- Sensitization leading to increased craving for the drug (correct)
- Decreased receptor density
How do recreational drugs typically alter mood and behavior?
How do recreational drugs typically alter mood and behavior?
What triggers the nervous system to compensate following drug overuse?
What triggers the nervous system to compensate following drug overuse?
Flashcards
Drug Tolerance
Drug Tolerance
A state where repeated drug use requires higher doses to achieve the same effect. This happens because the body adapts to the drug by reducing the number and sensitivity of receptors.
Agonist
Agonist
A drug that mimics the action of a natural neurotransmitter, stimulating specific receptors and increasing nerve activity.
Drug Addiction
Drug Addiction
A condition characterized by a compulsive craving for a drug, despite negative consequences. It develops due to the body's sensitization to the drug, increasing both the number and sensitivity of receptors.
Antagonist
Antagonist
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Sensitization
Sensitization
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Study Notes
Drug Tolerance
- Repeated use of agonist drugs causes tolerance.
- Agonists mimic natural neurotransmitters, triggering or enhancing normal cellular responses.
- Nerve impulses are transmitted due to agonist stimulation of specific receptors.
- The nervous system compensates for overstimulation.
- This compensation involves a decrease in receptor number and sensitivity.
- This desensitization leads to drug tolerance, requiring higher drug doses for the same effect.
Drug Addiction
- Repeated use of antagonist drugs leads to addiction.
- Antagonists block receptor sites, preventing natural neurotransmitter action.
- The nervous system responds by increasing receptor number and sensitivity.
- This sensitization leads to addiction, characterized by craving for more of the drug.
Neurotransmission and Recreational Drugs
- Many recreational drugs impact neurotransmission at synapses, influencing mood, cognition, perception, and behavior.
- These drugs often affect the brain's reward pathway.
- Drugs can mimic or interact with neurotransmitters in various ways, including stimulating release, mimicking action, inhibiting reuptake, blocking activity, or inhibiting breakdown.
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Description
Explore the mechanisms of drug tolerance and addiction in this quiz. Understand how agonist and antagonist drugs interact with neurotransmission and their effects on the nervous system. Gain insight into the physiological changes that lead to increased drug doses and the cravings associated with addiction.
