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Drug Solubility Enhancement Techniques

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Questions and Answers

What is the main problem associated with the quench cooling technique?

Inability to convert drugs into amorphous form

Low yield due to formation on a small scale (correct)

High material loss due to sticking to surfaces

Time-consuming process

Which technique is known for being very high yield, continuous, and having low labor costs?

Supercritical fluid impregnation

Quench cooling

Hot melt extrusion (correct)

Ball milling

What is a drawback of ball milling as mentioned in the text?

Time-consuming with less material conversion (correct)

Inability to convert drugs into amorphous form

Loss of material due to sticking to surfaces

Not suitable for heat-sensitive drugs

Which technique involves the use of a supercritical fluid like CO2?

Supercritical fluid impregnation Signup and view all the answers

What is a benefit of the supercritical fluid impregnation technique for drug dispersion?

Beneficial for heat-sensitive drugs Signup and view all the answers

Why is hot melt extrusion not suitable for heat-sensitive substances?

High temperature involved in the process Signup and view all the answers

What is the main characteristic of BCS 2 drugs described in the text?

Low solubility and good permeability Signup and view all the answers

How does reducing particle size enhance drug solubility according to the text?

It enhances surface area for intermolecular forces Signup and view all the answers

What method can be used to ensure the drug is ionized for stronger ionic bonds with the dissolution medium?

Formulating as a salt Signup and view all the answers

Why do amorphous solids have higher solubility compared to crystalline solids?

Amorphous solids are arranged in a disorganized manner Signup and view all the answers

What distinguishes amorphous solids from crystalline solids in terms of molecule arrangement?

Amorphous solids have molecules arranged in a regular lattice Signup and view all the answers