Podcast
Questions and Answers
What is the main difference between reinstatement following extinction and drug-seeking following abstinence?
What is the main difference between reinstatement following extinction and drug-seeking following abstinence?
- The intensity of craving is higher in reinstatement following extinction compared to drug-seeking following abstinence.
- Different brain systems are involved in reinstatement following extinction compared to drug-seeking following abstinence. (correct)
- Reinstatement following extinction occurs in different environments compared to drug-seeking following abstinence.
- The duration of the behavior is longer in reinstatement following extinction compared to drug-seeking following abstinence.
What role do the prelimbic cortex (dPFC) and basolateral amygdala (BLA) play in cocaine seeking after abstinence/extinction training?
What role do the prelimbic cortex (dPFC) and basolateral amygdala (BLA) play in cocaine seeking after abstinence/extinction training?
- BLA and dPFC play different roles in cocaine seeking after abstinence/extinction training. (correct)
- Both BLA and dPFC are not involved in cocaine seeking after abstinence/extinction training.
- BLA and dPFC have similar effects on cocaine seeking after abstinence/extinction training.
- BLA is responsible for reducing reinstatement, while dPFC increases craving.
What was the main finding of Phase 1 of the study?
What was the main finding of Phase 1 of the study?
- Rats consistently chose drugs over social interaction.
- Rats were indifferent to both social interaction and drugs.
- Rats showed significant preference for social interaction over drugs. (correct)
- Rats showed no preference between social interaction and drugs.
What is the main finding regarding the incubation of drug seeking in the study on heroin by Shalev et al, 2001?
What is the main finding regarding the incubation of drug seeking in the study on heroin by Shalev et al, 2001?
What was the purpose of Phase 2 in the study?
What was the purpose of Phase 2 in the study?
What was the key difference between the seeking and taking procedures in Phase 1?
What was the key difference between the seeking and taking procedures in Phase 1?
What was the outcome for rats that were shock/punishment resistant?
What was the outcome for rats that were shock/punishment resistant?
What is a common pattern observed in the incubation of craving for various substances?
What is a common pattern observed in the incubation of craving for various substances?
Which brain adaptation is associated with incubation of drug seeking?
Which brain adaptation is associated with incubation of drug seeking?
What is a factor correlated with varying levels of craving in animal models?
What is a factor correlated with varying levels of craving in animal models?
What is the main difference between reinstatement following extinction and drug-seeking following abstinence?
What is the main difference between reinstatement following extinction and drug-seeking following abstinence?
What is the primary finding regarding the role of the prelimbic cortex (dPFC) and basolateral amygdala (BLA) in cocaine seeking after abstinence/extinction training?
What is the primary finding regarding the role of the prelimbic cortex (dPFC) and basolateral amygdala (BLA) in cocaine seeking after abstinence/extinction training?
What is the main finding of the study on heroin by Shalev et al, 2001 regarding the incubation of drug seeking?
What is the main finding of the study on heroin by Shalev et al, 2001 regarding the incubation of drug seeking?
What was the main finding of Phase 1 in the study?
What was the main finding of Phase 1 in the study?
What was the purpose of Phase 2 in the study?
What was the purpose of Phase 2 in the study?
What is the main difference between reinstatement following extinction and drug-seeking following abstinence?
What is the main difference between reinstatement following extinction and drug-seeking following abstinence?
What was the outcome for rats that were shock/punishment resistant?
What was the outcome for rats that were shock/punishment resistant?
Which brain adaptation is associated with incubation of drug seeking?
Which brain adaptation is associated with incubation of drug seeking?
What is a factor correlated with varying levels of craving in animal models?
What is a factor correlated with varying levels of craving in animal models?
What is a common pattern observed in the incubation of craving for various substances?
What is a common pattern observed in the incubation of craving for various substances?
Rats in Phase 1 were trained to press the same lever for both social interaction and drugs.
Rats in Phase 1 were trained to press the same lever for both social interaction and drugs.
In Phase 2, the introduction of triggers was meant to induce rats to choose drugs.
In Phase 2, the introduction of triggers was meant to induce rats to choose drugs.
The punishment-induced abstinence in Phase 2 aimed to model the positive effects of drug taking/seeking.
The punishment-induced abstinence in Phase 2 aimed to model the positive effects of drug taking/seeking.
In Phase 2, the introduction of punishment was for both seeking and taking drugs.
In Phase 2, the introduction of punishment was for both seeking and taking drugs.
During Phase 3, the introduction of stress triggers led to an increase in drug-seeking behavior.
During Phase 3, the introduction of stress triggers led to an increase in drug-seeking behavior.
Match the following concepts with their corresponding descriptions:
Match the following concepts with their corresponding descriptions:
Match the following procedures with their corresponding descriptions:
Match the following procedures with their corresponding descriptions:
Match the following findings with their corresponding results:
Match the following findings with their corresponding results:
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Study Notes
Incubation of Drug Seeking: Mechanisms and Implications
- Incubation of craving observed in animal models for cocaine, sucrose, smoking, and alcohol
- Craving increases over time in a pattern resembling an inverted U shape
- Brain adaptations, including changes in BDNF levels, are associated with incubation of drug seeking
- Injecting BDNF directly in the VTA increases craving in rats
- Similar mechanisms for opioids and cocaine seeking involve long-term adaptations in the NAc AMPA receptors
- Alternative reward models like contingency management with food and social interaction are being explored
- Reinstatement procedures in animals have poor predictive validity for human clinical studies
- Extinction and voluntary abstinence are important factors in studying drug seeking behavior
- Different time delays to extinction in animal models correlate with varying levels of craving
- Stress-induced reinstatement of drug seeking becomes stronger with increased incubation time
- Incubation of craving has been observed for natural rewards like sucrose, indicating it is not limited to drugs
- Brain adaptations, including changes in BDNF and NGF levels, are correlated with changes in behavior during incubation of drug seeking
Incubation of Drug Seeking: Mechanisms and Implications
- Incubation of craving observed in animal models for cocaine, sucrose, smoking, and alcohol
- Craving increases over time in a pattern resembling an inverted U shape
- Brain adaptations, including changes in BDNF levels, are associated with incubation of drug seeking
- Injecting BDNF directly in the VTA increases craving in rats
- Similar mechanisms for opioids and cocaine seeking involve long-term adaptations in the NAc AMPA receptors
- Alternative reward models like contingency management with food and social interaction are being explored
- Reinstatement procedures in animals have poor predictive validity for human clinical studies
- Extinction and voluntary abstinence are important factors in studying drug seeking behavior
- Different time delays to extinction in animal models correlate with varying levels of craving
- Stress-induced reinstatement of drug seeking becomes stronger with increased incubation time
- Incubation of craving has been observed for natural rewards like sucrose, indicating it is not limited to drugs
- Brain adaptations, including changes in BDNF and NGF levels, are correlated with changes in behavior during incubation of drug seeking
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