14 Questions
Which of the following is the correct definition of an 'antagonist'?
A ligand that prevents the effects of an agonist.
What is the effect of a reversible competitive antagonist on a log dose response curve?
It shifts the curve to the right.
What is the effect of a non-competitive antagonist on a log dose response curve?
It has no effect on the curve.
Which type of antagonist binds to the same site as the endogenous ligand?
Competitive
What is the main difference between reversible and irreversible antagonists?
Reversible antagonists can be easily reversed by increasing the concentration of the agonist while irreversible antagonists cannot
What is the median effective dose (ED50)?
The dose required to produce a specified response in 50% of the population
What is the difference between therapeutic index and therapeutic window?
Therapeutic index refers to the range of doses that produce a therapeutic effect, while therapeutic window refers to the range of doses that produce a toxic effect
Which of the following receptor types is regulated by a desensitized state with higher affinity for the agon?
Ligand-gated ion channels
Which type of receptor is characterized by containing receptor subunits around a 'central pore' that also acts as the ion channel?
Ligand-gated ion channels
Which receptor type 'receives' and 'transmits' signals through receptor tyrosine kinases?
Receptor tyrosine kinases
Which of the following is true about receptor tyrosine kinases (RTKs)?
RTKs have an extracellular domain responsible for capturing signal
Which of the following is true about Growth receptor binding protein 2 (Grb2)?
Grb2 is an adapter protein that links signaling molecules
Which of the following is true about Ras?
Ras binds GTP to become active
Which of the following is true about nuclear receptors?
Nuclear receptors require phosphorylation for activation
Test your knowledge on drug receptor interactions and the different types of antagonists. Learn about reversible, irreversible, competitive, and non-competitive antagonists and how they affect the dose-response curve.
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