Drug Reactivity and pH

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What characteristic is important for bioavailability and changes on storage?

Melting time of suppositories

Drug leakage from liposomes

Dissolution of a drug substance (correct)

Release rate from polymeric matrix dosage

How can protection from light be achieved according to the text?

Storing in a dark room

Sealing the product in a transparent bag

Using primary and secondary packaging made up of light-resistant material (correct)

Exposing the product to sunlight

Which factor significantly affects the stability of products according to the text?

Packaging color

Humidity in the storage area

Resistance of packaging material to moisture and light (correct)

Temperature at which the product is stored

What can reduce the effect of oxygen in products according to the text?

Incorporating oxygen adsorbents such as iron powder Signup and view all the answers

Which study provides insight into the mechanism of changes in reactions?

Kinetic studies Signup and view all the answers

How does moisture sensitivity impact the mechanical strength of products according to the text?

It weakens the mechanical strength Signup and view all the answers

What quality attribute of a drug product is evaluated by pharmaceutical scientists and regulators to determine stability?

Functional changes in dosage forms with time Signup and view all the answers

How can changes in the stability of pharmaceutical products affect drug safety and efficacy?

Changes in chemical or physical properties Signup and view all the answers

Which factor plays a significant role in the degradation rate of pharmaceutical products?

Temperature Signup and view all the answers

How does storage in humid conditions impact the mechanical strength of tablets?

Decreases mechanical strength Signup and view all the answers

In drug stability studies, what specific aspect should be evaluated for physical changes in dosage forms?

Dosage form-specific changes Signup and view all the answers

Which type of reaction can be used to assess chemical stability for drugs and excipients?

Hydrolysis reaction Signup and view all the answers

Why is the reactivity of a drug pH-dependent?

Because the fraction of drug present in different forms depends on the pH of the solution. Signup and view all the answers

How can a water-miscible buffer contribute to the stability of a drug?

By preventing a shift in the pH of the solution. Signup and view all the answers

What is the impact of hygroscopic materials on drug stability?

They absorb moisture from the atmosphere, affecting drug stability. Signup and view all the answers

Why should pharmaceutical air conditioning be set below 40% relative humidity?

To maintain drugs unaffected by relative humidity. Signup and view all the answers

How does temperature impact the decomposition of drugs?

An increase in temperature accelerates decomposition reactions. Signup and view all the answers

How do some buffers potentially affect drug stability through catalysis?

By producing ions that catalyze hydrolysis reactions. Signup and view all the answers

Drug Reactivity and pH

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