Questions and Answers
What class does Bumetanide belong to?
What is the mechanism of action for Bumetanide?
Inhibits electrolyte reabsorption in the ascending loop of Henle leading to diuresis
What are the indications for using Bumetanide? (Select all that apply)
Which of the following is a contraindication for Bumetanide?
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What are some common adverse reactions of Bumbletide?
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What is an important note regarding the administration of Bumetanide?
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What drug interactions should be considered when administering Bumetanide?
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What is the recommended adult dosage of Bumetanide?
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What is the onset of action for Bumetanide when administered IV?
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What is the peak effect time for Bumetanide IV administration?
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What is the duration of action for Bumetanide?
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What is the optional drug box minimum supply for Bumetanide?
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What special note should be made regarding Bumetanide?
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Study Notes
Drug Profile for Bumetanide
- Class: Loop diuretic
- Mechanism of Action: Inhibits electrolyte reabsorption in the ascending loop of Henle, resulting in increased urine production (diuresis).
Indications and Uses
- Effective for treating pulmonary edema and congestive heart failure.
Contraindications
- Not suitable for patients with hypersensitivity to the drug, anuria, or electrolyte deficiencies.
- Caution advised in cases of hepatic cirrhosis, ascites, history of gout, or if allergic to furosemide.
Adverse Reactions
- Common side effects include dizziness, headaches, and muscle cramps.
- Potential for hypotension and EKG changes due to electrolyte imbalances (hypokalemia, hyponatremia, hypocalcemia, hypomagnesemia).
- Gastrointestinal disturbances such as nausea, vomiting, diarrhea, and dry mouth may occur.
- Ringing in the ears (tinnitus) can also be a side effect.
Administration Notes
- High doses or frequent use, particularly in the elderly, may lead to excessive diuresis or hypovolemia, risking thrombi and emboli formation.
- Risk of hypokalemic-induced digoxin toxicity.
Incompatibilities and Drug Interactions
- NSAIDs can diminish the diuretic effect of bumetanide.
- Concurrent use with lithium may elevate blood levels and risk for toxicity.
- Enhances effects of various antihypertensive medications.
Dosage Information
- Adult dosage typically ranges from 0.5 to 1.0 mg, administered IV slowly over 1 to 2 minutes or via intramuscular injection.
Onset, Peak, and Duration
- Onset: Immediate when administered IV.
- Peak Effect: 15 to 30 minutes after IV administration.
- Duration of Action: Lasts approximately 2 to 4 hours.
Drug Box Supply
- Minimum optional supply of 4 mg for emergency situations.
Special Notes
- Unlike furosemide, bumetanide does not have vasodilatory effects.
- Allergies to sulfa drugs may result in hypersensitivity reactions.
- Use in pregnant patients may reduce blood supply to the developing fetus; safety in pediatric patients remains unestablished.
- Potency comparison: 1 mg of bumetanide is equivalent to 40 mg of furosemide.
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Description
Explore the key concepts related to Bumetanide, a loop diuretic used for managing pulmonary edema and congestive heart failure. This quiz covers its mechanism of action, indications, contraindications, and important characteristics. Test your knowledge and understanding of this vital medication.
