Bumetanide

Questions and Answers

What is the class for Bumetanide?

Loop diuretic

What is the mechanism of action (MOA) for Bumetanide?

Inhibits the reabsorption of sodium and chloride in the ascending limb of the loop of Henle

What are the indications for Bumetanide?

Pulmonary edema, CHF

What are the contraindications for Bumetanide?

Hypersensitivity, hypovolemia, anuria, electrolyte deficiencies, hepatic coma Signup and view all the answers

What are the adverse reactions/side effects of Bumetanide?

Dizziness, headache, orthostatic hypotension, ECG changes due to electrolyte depletion, nausea and vomiting, diarrhea, cramps, metabolic alkalosis, hypovolemia, dehydration Signup and view all the answers

What are the drug interactions for Bumetanide?

NSAIDs reduce diuretic effect; may increase blood levels of lithium; antihypertensives and diuretics can cause further hypotension and fluid depletion Signup and view all the answers

How is Bumetanide supplied?

0.25 mg/mL vials Signup and view all the answers

What is the adult dosage and administration for Bumetanide?

0.5-1 mg IV slowly over 1-2 minutes, or IM Signup and view all the answers

What is the pediatric dosage and administration for Bumetanide?

Safety and effectiveness in pediatric population is not established Signup and view all the answers

What is the duration of action for Bumetanide?

Onset: Immediate, Peak effect: 15-30 min, Duration: 2-4 hours Signup and view all the answers

What is the trade name for Bumetanide?

Bumex Signup and view all the answers

Study Notes

Bumetanide Overview

Class: Loop diuretic effective for managing fluid retention.
Mechanism of Action: Inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle.

Indications

Primarily used for the treatment of pulmonary edema.
Effective in managing congestive heart failure (CHF).

Contraindications

Not suitable for individuals with hypersensitivity to the drug.
Caution in cases of hypovolemia, anuria, electrolyte deficiencies, and hepatic coma.

Adverse Reactions

Common side effects include dizziness and headache.
May cause orthostatic hypotension and ECG changes due to electrolyte depletion.
Gastrointestinal effects: nausea, vomiting, diarrhea, and cramps.
Other risks include metabolic alkalosis, hypovolemia, and dehydration.

Drug Interactions

NSAIDs may diminish the diuretic effect of Bumetanide.
Can increase blood levels of lithium, risking lithium toxicity.
Concurrent use of antihypertensives and diuretics may exacerbate hypotension and fluid depletion.

Dosage and Administration

Supplied as 0.25 mg/mL vials for intravenous or intramuscular use.
Adult dosage: 0.5-1 mg administered slowly over 1-2 minutes.
Pediatric safety and efficacy not established; caution advised.

Pharmacokinetics

Onset of action is immediate with peak effects occurring within 15-30 minutes.
Duration of diuretic effect lasts approximately 2-4 hours.

Trade Name

Marketed under the trade name Bumex.

Description

Test your knowledge of Bumetanide (Bumex) with this set of flashcards. Each card covers critical aspects such as its class, mechanism of action, indications, and contraindications. Ideal for students and professionals studying pharmacology.

Bumetanide - Bumex Flashcards