Bumetanide - Bumex Flashcards

Bumetanide Overview

• Class: Loop diuretic effective for managing fluid retention.
• Mechanism of Action: Inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle.

Indications

• Primarily used for the treatment of pulmonary edema.
• Effective in managing congestive heart failure (CHF).

Contraindications

• Not suitable for individuals with hypersensitivity to the drug.
• Caution in cases of hypovolemia, anuria, electrolyte deficiencies, and hepatic coma.

Adverse Reactions

• Common side effects include dizziness and headache.
• May cause orthostatic hypotension and ECG changes due to electrolyte depletion.
• Gastrointestinal effects: nausea, vomiting, diarrhea, and cramps.
• Other risks include metabolic alkalosis, hypovolemia, and dehydration.

Drug Interactions

• NSAIDs may diminish the diuretic effect of Bumetanide.
• Can increase blood levels of lithium, risking lithium toxicity.
• Concurrent use of antihypertensives and diuretics may exacerbate hypotension and fluid depletion.

Dosage and Administration

• Supplied as 0.25 mg/mL vials for intravenous or intramuscular use.
• Adult dosage: 0.5-1 mg administered slowly over 1-2 minutes.
• Pediatric safety and efficacy not established; caution advised.

Pharmacokinetics

• Onset of action is immediate with peak effects occurring within 15-30 minutes.
• Duration of diuretic effect lasts approximately 2-4 hours.

Trade Name

• Marketed under the trade name Bumex.