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What is the class for Bumetanide?
What is the class for Bumetanide?
Loop diuretic
What is the mechanism of action (MOA) for Bumetanide?
What is the mechanism of action (MOA) for Bumetanide?
Inhibits the reabsorption of sodium and chloride in the ascending limb of the loop of Henle
What are the indications for Bumetanide?
What are the indications for Bumetanide?
Pulmonary edema, CHF
What are the contraindications for Bumetanide?
What are the contraindications for Bumetanide?
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What are the adverse reactions/side effects of Bumetanide?
What are the adverse reactions/side effects of Bumetanide?
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What are the drug interactions for Bumetanide?
What are the drug interactions for Bumetanide?
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How is Bumetanide supplied?
How is Bumetanide supplied?
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What is the adult dosage and administration for Bumetanide?
What is the adult dosage and administration for Bumetanide?
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What is the pediatric dosage and administration for Bumetanide?
What is the pediatric dosage and administration for Bumetanide?
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What is the duration of action for Bumetanide?
What is the duration of action for Bumetanide?
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What is the trade name for Bumetanide?
What is the trade name for Bumetanide?
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Study Notes
Bumetanide Overview
- Class: Loop diuretic effective for managing fluid retention.
- Mechanism of Action: Inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle.
Indications
- Primarily used for the treatment of pulmonary edema.
- Effective in managing congestive heart failure (CHF).
Contraindications
- Not suitable for individuals with hypersensitivity to the drug.
- Caution in cases of hypovolemia, anuria, electrolyte deficiencies, and hepatic coma.
Adverse Reactions
- Common side effects include dizziness and headache.
- May cause orthostatic hypotension and ECG changes due to electrolyte depletion.
- Gastrointestinal effects: nausea, vomiting, diarrhea, and cramps.
- Other risks include metabolic alkalosis, hypovolemia, and dehydration.
Drug Interactions
- NSAIDs may diminish the diuretic effect of Bumetanide.
- Can increase blood levels of lithium, risking lithium toxicity.
- Concurrent use of antihypertensives and diuretics may exacerbate hypotension and fluid depletion.
Dosage and Administration
- Supplied as 0.25 mg/mL vials for intravenous or intramuscular use.
- Adult dosage: 0.5-1 mg administered slowly over 1-2 minutes.
- Pediatric safety and efficacy not established; caution advised.
Pharmacokinetics
- Onset of action is immediate with peak effects occurring within 15-30 minutes.
- Duration of diuretic effect lasts approximately 2-4 hours.
Trade Name
- Marketed under the trade name Bumex.
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Test your knowledge of Bumetanide (Bumex) with this set of flashcards. Each card covers critical aspects such as its class, mechanism of action, indications, and contraindications. Ideal for students and professionals studying pharmacology.
