Drug Pharmacokinetics Quiz

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Questions and Answers

What does the elimination half-life depend on?

The time of day the drug is taken
The duration of drug therapy
Initial concentration of the drug
Clearance and volume of distribution of the drug (correct)

What is the half-life of a drug?

The time required for the body to eliminate one half of the drug it contains (correct)
The time required for the body to eliminate one quarter of the drug it contains
The time required for the body to eliminate all of the drug it contains
The time required for the body to eliminate three quarters of the drug it contains

What is the characteristic of exponential decay in relation to half-life?

The time required for a given fraction of drug to disappear decreases over time
The time required for a given fraction of drug to disappear is always the same (correct)
The time required for a given fraction of drug to disappear increases over time
The time required for a given fraction of drug to disappear varies with initial concentration

What is the biological half-life not indicative of?

The time for the response to decline by 50% (C) Signup and view all the answers

What is the formula for elimination half-life (t ½)?

$t_{1/2} = 0.693/K_{elim}$ (B) Signup and view all the answers

What is the characteristic of exponential decay in relation to half-life?

The time required for a given fraction of drug to disappear is always the same, regardless of the time or concentration at which one begins measurements. (C) Signup and view all the answers

What does the biological half-life indicate?

The time needed to decrease the body drug level by one half of its initial level. (C) Signup and view all the answers

What factors cause non-parallelism between blood concentration and pharmacological response intensity?

Threshold concentration and latency of response. (C) Signup and view all the answers

What is the formula for elimination half-life ($t_{1/2}$)?

$t_{1/2} = 0.693 / Kelim$ (D) Signup and view all the answers

What does the half-life of a drug determine?

The time required for the body to eliminate by metabolizing, or excretion, or by both, one half of the initial dose of the drug. (C) Signup and view all the answers