Drug Movement in ADME Mechanisms Quiz
14 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which mechanism of drug movement requires a carrier and energy?

  • Active transport (correct)
  • Passive diffusion
  • Pinocytosis
  • Facilitated diffusion

Which mechanism of drug movement does not require a carrier or energy?

  • Pinocytosis
  • Active transport
  • Passive diffusion (correct)
  • Facilitated diffusion

Which mechanism of drug movement is necessary for the transport of endogenous compounds with slow movement by simple diffusion?

  • Active transport
  • Facilitated diffusion (correct)
  • Passive diffusion
  • Pinocytosis

What is the main mechanism for transport of the majority of drugs in the body?

<p>Passive diffusion (B)</p> Signup and view all the answers

Which mechanism involves the transport of drugs by being engulfed within molecular vesicles?

<p>Pinocytosis (C)</p> Signup and view all the answers

Which mechanism of drug movement involves the movement of a drug molecule according to concentration gradient?

<p>Passive diffusion (C)</p> Signup and view all the answers

Which type of drug is less ionized in an acidic medium?

<p>Weak acidic drugs (B)</p> Signup and view all the answers

What is the definition of pKa?

<p>The pH at which the drug is 50% ionized and 50% unionized (C)</p> Signup and view all the answers

Which barrier primarily allows drugs to cross by simple diffusion?

<p>Placental barrier (B)</p> Signup and view all the answers

What does the blood-brain barrier mainly protect against?

<p>Circulating toxins or pathogens (A)</p> Signup and view all the answers

Which factor determines the extent of drug absorption through the placental barrier?

<p>All of the above (D)</p> Signup and view all the answers

What determines the passage of a drug across a cell membrane?

<p>$pH$ gradient across the cell membrane and drug pKa (A)</p> Signup and view all the answers

What is the main function of the blood-brain barrier?

<p>To regulate the movement of drugs between blood and brain (D)</p> Signup and view all the answers

Which type of drug is less ionized in an alkaline medium?

<p>Weak basic drugs (D)</p> Signup and view all the answers

Study Notes

Mechanisms of Drug Movement

  • Active transport requires a carrier and energy.
  • Passive transport does not require a carrier or energy.
  • Facilitated diffusion is necessary for the transport of endogenous compounds with slow movement by simple diffusion.
  • Passive transport is the main mechanism for the transport of the majority of drugs in the body.

Transport Mechanisms

  • Endocytosis involves the transport of drugs by being engulfed within molecular vesicles.
  • Simple diffusion involves the movement of a drug molecule according to its concentration gradient.

Drug Ionization

  • A basic drug is less ionized in an acidic medium.
  • The pKa is the pH at which a drug is 50% ionized and 50% non-ionized.

Barriers to Drug Movement

  • Lipid-soluble drugs can cross the blood-brain barrier by simple diffusion.
  • The blood-brain barrier mainly protects against the passage of hydrophilic substances.
  • The extent of drug absorption through the placental barrier is determined by the drug's lipophilicity.
  • The passage of a drug across a cell membrane is determined by its lipophilicity and the concentration gradient.
  • The main function of the blood-brain barrier is to protect the central nervous system from toxic substances.
  • An acidic drug is less ionized in an alkaline medium.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Description

Test your knowledge on the mechanisms of drug movement during ADME (Absorption, Distribution, Metabolism, and Excretion). Learn about passive diffusion, active transport, facilitated diffusion, and pinocytosis as mechanisms for drug transport in the body.

More Like This

ADME and Drug Design Process Stages
22 questions
Drug Metabolism: ADME Basics
59 questions

Drug Metabolism: ADME Basics

CongratulatoryIntelligence5915 avatar
CongratulatoryIntelligence5915
ADME: Drug Absorption and Metabolism
37 questions
Use Quizgecko on...
Browser
Browser