18 Questions
What is the primary mechanism of action of SGLT2 inhibitors?
Inhibiting the SGLT2 receptors in the proximal tubule to prevent glucose reabsorption
What is the typical reduction in HbA1c observed with SGLT2 inhibitor therapy?
0.7-1.1%
Which of the following is a common adverse effect associated with SGLT2 inhibitor use?
Genitourinary infections
How do SGLT2 inhibitors compare to incretin mimetics in terms of their mechanism of action?
SGLT2 inhibitors have supraphysiologic effects on glucose homeostasis, while incretin mimetics have physiologic effects
Which of the following is a known cardiovascular benefit associated with SGLT2 inhibitor use?
Reduced risk of heart failure hospitalization
What is a potential disadvantage of SGLT2 inhibitor therapy?
Increased risk of hypotension in patients with hypovolemia
What is the typical weight loss observed with SGLT2 inhibitor therapy?
4-6 kg
Which of the following is a common comorbidity associated with diabetes?
All of the above
What is the leading cause of hospitalization in patients with diabetes?
Heart failure
Which of the following is a potential disadvantage of using SGLT2 inhibitors for the management of diabetes?
Increased risk of hypotension in individuals with hypovolemia
How do SGLT2 inhibitors compare to incretin mimetics in terms of their mechanism of action?
SGLT2 inhibitors have supraphysiologic effects, while incretin mimetics have physiologic effects
What is the primary mechanism of action of SGLT2 inhibitors in the management of diabetes?
Inhibiting the reabsorption of glucose in the proximal renal tubules
Which of the following is a known cardiovascular benefit associated with the use of SGLT2 inhibitors?
Reduced risk of atherosclerosis progression
Which of the following is a common comorbidity associated with diabetes?
Decreased fibrinolytic activity
What is the typical weight loss observed with SGLT2 inhibitor therapy in patients with diabetes?
Weight loss of 2-7 kg
What is the leading cause of hospitalization in patients with diabetes?
Heart failure
Which of the following is a common adverse effect associated with the use of SGLT2 inhibitors?
Increased risk of genitourinary infections
What is the typical reduction in HbA1c observed with SGLT2 inhibitor therapy in patients with diabetes?
Reduction of 0.7-1.1%
Test your knowledge on the mechanism of action, efficacy, advantages, and disadvantages of SGLT2 inhibitors in pharmacology. Learn how these drugs work in the kidneys and their impact on glucose reabsorption, weight loss, blood pressure, and more.
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