Drug MoA: SGLT2 Inhibitors Quiz

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What is the primary mechanism of action of SGLT2 inhibitors?

Decreasing the rate of gastric emptying to slow glucose absorption

Increasing insulin secretion to lower blood glucose levels

Inhibiting the SGLT2 receptors in the proximal tubule to prevent glucose reabsorption (correct)

Increasing glucagon secretion to raise blood glucose levels

What is the typical reduction in HbA1c observed with SGLT2 inhibitor therapy?

0.7-1.1% (correct)

0.8-1.9%

No significant reduction in HbA1c

2-3%

Which of the following is a common adverse effect associated with SGLT2 inhibitor use?

Genitourinary infections (correct)

Liver toxicity

Decreased HDL cholesterol

Hypoglycemia

How do SGLT2 inhibitors compare to incretin mimetics in terms of their mechanism of action?

SGLT2 inhibitors have supraphysiologic effects on glucose homeostasis, while incretin mimetics have physiologic effects Signup and view all the answers

Which of the following is a known cardiovascular benefit associated with SGLT2 inhibitor use?

Reduced risk of heart failure hospitalization Signup and view all the answers

What is a potential disadvantage of SGLT2 inhibitor therapy?

Increased risk of hypotension in patients with hypovolemia Signup and view all the answers

What is the typical weight loss observed with SGLT2 inhibitor therapy?

4-6 kg Signup and view all the answers

Which of the following is a common comorbidity associated with diabetes?

All of the above Signup and view all the answers

What is the leading cause of hospitalization in patients with diabetes?

Heart failure Signup and view all the answers

Which of the following is a potential disadvantage of using SGLT2 inhibitors for the management of diabetes?

Increased risk of hypotension in individuals with hypovolemia Signup and view all the answers

How do SGLT2 inhibitors compare to incretin mimetics in terms of their mechanism of action?

SGLT2 inhibitors have supraphysiologic effects, while incretin mimetics have physiologic effects Signup and view all the answers

What is the primary mechanism of action of SGLT2 inhibitors in the management of diabetes?

Inhibiting the reabsorption of glucose in the proximal renal tubules Signup and view all the answers

Which of the following is a known cardiovascular benefit associated with the use of SGLT2 inhibitors?

Reduced risk of atherosclerosis progression Signup and view all the answers

Which of the following is a common comorbidity associated with diabetes?

Decreased fibrinolytic activity Signup and view all the answers

What is the typical weight loss observed with SGLT2 inhibitor therapy in patients with diabetes?

Weight loss of 2-7 kg Signup and view all the answers

What is the leading cause of hospitalization in patients with diabetes?

Heart failure Signup and view all the answers

Which of the following is a common adverse effect associated with the use of SGLT2 inhibitors?

Increased risk of genitourinary infections Signup and view all the answers

What is the typical reduction in HbA1c observed with SGLT2 inhibitor therapy in patients with diabetes?

Reduction of 0.7-1.1% Signup and view all the answers

Drug MoA: SGLT2 Inhibitors Quiz

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Questions and Answers

What is the primary mechanism of action of SGLT2 inhibitors?

What is the typical reduction in HbA1c observed with SGLT2 inhibitor therapy?

Which of the following is a common adverse effect associated with SGLT2 inhibitor use?

How do SGLT2 inhibitors compare to incretin mimetics in terms of their mechanism of action?

Which of the following is a known cardiovascular benefit associated with SGLT2 inhibitor use?

What is a potential disadvantage of SGLT2 inhibitor therapy?

What is the typical weight loss observed with SGLT2 inhibitor therapy?

Which of the following is a common comorbidity associated with diabetes?

What is the leading cause of hospitalization in patients with diabetes?

Which of the following is a potential disadvantage of using SGLT2 inhibitors for the management of diabetes?

How do SGLT2 inhibitors compare to incretin mimetics in terms of their mechanism of action?

What is the primary mechanism of action of SGLT2 inhibitors in the management of diabetes?

Which of the following is a known cardiovascular benefit associated with the use of SGLT2 inhibitors?

Which of the following is a common comorbidity associated with diabetes?

What is the typical weight loss observed with SGLT2 inhibitor therapy in patients with diabetes?

What is the leading cause of hospitalization in patients with diabetes?

Which of the following is a common adverse effect associated with the use of SGLT2 inhibitors?

What is the typical reduction in HbA1c observed with SGLT2 inhibitor therapy in patients with diabetes?

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