Drug MoA: SGLT2 Inhibitors Quiz

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Questions and Answers

What is the primary mechanism of action of SGLT2 inhibitors?

  • Decreasing the rate of gastric emptying to slow glucose absorption
  • Increasing insulin secretion to lower blood glucose levels
  • Inhibiting the SGLT2 receptors in the proximal tubule to prevent glucose reabsorption (correct)
  • Increasing glucagon secretion to raise blood glucose levels

What is the typical reduction in HbA1c observed with SGLT2 inhibitor therapy?

  • 0.7-1.1% (correct)
  • 0.8-1.9%
  • No significant reduction in HbA1c
  • 2-3%

Which of the following is a common adverse effect associated with SGLT2 inhibitor use?

  • Genitourinary infections (correct)
  • Liver toxicity
  • Decreased HDL cholesterol
  • Hypoglycemia

How do SGLT2 inhibitors compare to incretin mimetics in terms of their mechanism of action?

<p>SGLT2 inhibitors have supraphysiologic effects on glucose homeostasis, while incretin mimetics have physiologic effects (C)</p> Signup and view all the answers

Which of the following is a known cardiovascular benefit associated with SGLT2 inhibitor use?

<p>Reduced risk of heart failure hospitalization (A)</p> Signup and view all the answers

What is a potential disadvantage of SGLT2 inhibitor therapy?

<p>Increased risk of hypotension in patients with hypovolemia (D)</p> Signup and view all the answers

What is the typical weight loss observed with SGLT2 inhibitor therapy?

<p>4-6 kg (C)</p> Signup and view all the answers

Which of the following is a common comorbidity associated with diabetes?

<p>All of the above (D)</p> Signup and view all the answers

What is the leading cause of hospitalization in patients with diabetes?

<p>Heart failure (C)</p> Signup and view all the answers

Which of the following is a potential disadvantage of using SGLT2 inhibitors for the management of diabetes?

<p>Increased risk of hypotension in individuals with hypovolemia (B)</p> Signup and view all the answers

How do SGLT2 inhibitors compare to incretin mimetics in terms of their mechanism of action?

<p>SGLT2 inhibitors have supraphysiologic effects, while incretin mimetics have physiologic effects (D)</p> Signup and view all the answers

What is the primary mechanism of action of SGLT2 inhibitors in the management of diabetes?

<p>Inhibiting the reabsorption of glucose in the proximal renal tubules (A)</p> Signup and view all the answers

Which of the following is a known cardiovascular benefit associated with the use of SGLT2 inhibitors?

<p>Reduced risk of atherosclerosis progression (D)</p> Signup and view all the answers

Which of the following is a common comorbidity associated with diabetes?

<p>Decreased fibrinolytic activity (B)</p> Signup and view all the answers

What is the typical weight loss observed with SGLT2 inhibitor therapy in patients with diabetes?

<p>Weight loss of 2-7 kg (C)</p> Signup and view all the answers

What is the leading cause of hospitalization in patients with diabetes?

<p>Heart failure (C)</p> Signup and view all the answers

Which of the following is a common adverse effect associated with the use of SGLT2 inhibitors?

<p>Increased risk of genitourinary infections (D)</p> Signup and view all the answers

What is the typical reduction in HbA1c observed with SGLT2 inhibitor therapy in patients with diabetes?

<p>Reduction of 0.7-1.1% (C)</p> Signup and view all the answers

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