Podcast
Questions and Answers
What is the primary goal of drug metabolism?
What is the primary goal of drug metabolism?
- To increase protein binding
- To reduce the drug's bioavailability
- To increase drug solubility
- To inactivate or detoxify foreign substances (correct)
What happens during Phase 1 metabolism?
What happens during Phase 1 metabolism?
- A binding site is introduced for hydrophilic compounds (correct)
- The drug is excreted by the kidneys
- Prodrugs are activated
- The drug is inactivated by liver enzymes
Which organ is NOT mentioned as a site where drug metabolism takes place?
Which organ is NOT mentioned as a site where drug metabolism takes place?
- Gut
- Pancreas (correct)
- Brain
- Liver
Which route of drug administration typically results in 100% bioavailability?
Which route of drug administration typically results in 100% bioavailability?
What is the purpose of the first-pass effect in drug metabolism?
What is the purpose of the first-pass effect in drug metabolism?
What factors influence drug distribution in terms of tissue targets?
What factors influence drug distribution in terms of tissue targets?
Which of the following statements about drug metabolism is false?
Which of the following statements about drug metabolism is false?
What influences a drug's bioavailability?
What influences a drug's bioavailability?
'Xenobiotic' refers to:
'Xenobiotic' refers to:
What is the main function of phase 2 metabolism?
What is the main function of phase 2 metabolism?
What type of enzymes cleave glucuronide conjugates in the gut?
What type of enzymes cleave glucuronide conjugates in the gut?
Where are most water-soluble drug metabolites excreted?
Where are most water-soluble drug metabolites excreted?
What is pharmacodynamics primarily concerned with?
What is pharmacodynamics primarily concerned with?
Which type of substance interferes with or inhibits the physiological action of another substance?
Which type of substance interferes with or inhibits the physiological action of another substance?
What do competitive substances have in common?
What do competitive substances have in common?
What is an agonist substance known for?
What is an agonist substance known for?
Allosteric substances interact with receptors in what manner?
Allosteric substances interact with receptors in what manner?
Which factor influences drug absorption by requiring only non-ionized forms of drugs to easily pass through a lipid bilayer?
Which factor influences drug absorption by requiring only non-ionized forms of drugs to easily pass through a lipid bilayer?
What is the main goal of pharmacology as described in the text?
What is the main goal of pharmacology as described in the text?
Which statement accurately describes drug distribution after administration?
Which statement accurately describes drug distribution after administration?
How do most drugs get absorbed according to the text?
How do most drugs get absorbed according to the text?
What is the effect of pH on drug absorption in the digestive tract?
What is the effect of pH on drug absorption in the digestive tract?
Which type of antagonist binds to a different site on the receptor than the agonist?
Which type of antagonist binds to a different site on the receptor than the agonist?
What is the role of phase 1 metabolism in drug processing?
What is the role of phase 1 metabolism in drug processing?
Why is bioavailability an important consideration in pharmacology?
Why is bioavailability an important consideration in pharmacology?
Which factor influences individual drug responses according to the text?
Which factor influences individual drug responses according to the text?
What is the purpose of a Therapeutic Index (TI) in pharmacology?
What is the purpose of a Therapeutic Index (TI) in pharmacology?
What does LD50 stand for in pharmacology?
What does LD50 stand for in pharmacology?
Why is it advised to use generic names over brand names when prescribing drugs?
Why is it advised to use generic names over brand names when prescribing drugs?
What should be included in prescription requirements according to the text?
What should be included in prescription requirements according to the text?
What does ED50 represent in pharmacology?
What does ED50 represent in pharmacology?
What is the relationship between LD50 and ED50 used for in pharmacology?
What is the relationship between LD50 and ED50 used for in pharmacology?
