Podcast
Questions and Answers
Which dietary factor inhibits CYP3A4, leading to toxicity of midazolam, cyclosporine, and diazepam?
Which dietary factor inhibits CYP3A4, leading to toxicity of midazolam, cyclosporine, and diazepam?
- Grapefruit juice (correct)
- Cruciferous vegetables
- Ethanol
- Barbecued meat
Which genetic factor results from the presence of two or more variant forms of a specific DNA sequence among different individuals or populations?
Which genetic factor results from the presence of two or more variant forms of a specific DNA sequence among different individuals or populations?
- CYP1A2 induction
- CYP3A4 inhibition
- Genetic polymorphisms (correct)
- CYP2D6 upregulation
Which environmental factor induces CYP1A1 and CYP1A2, affecting the metabolism of theophylline?
Which environmental factor induces CYP1A1 and CYP1A2, affecting the metabolism of theophylline?
- Insecticides
- Cigarette smoke (correct)
- High-altitude hypoxia
- Heavy metal exposure
Which substance inhibits CYP3A4, leading to an increased toxic effect of nifedipine, clarithromycin, and simvastatin?
Which substance inhibits CYP3A4, leading to an increased toxic effect of nifedipine, clarithromycin, and simvastatin?
Which enzyme is responsible for the 4-hydroxylation of phenytoin in Phase I metabolism?
Which enzyme is responsible for the 4-hydroxylation of phenytoin in Phase I metabolism?
In Phase II Metabolism, which enzyme is responsible for conjugating a molecule of glucuronic acid to phenytoin to increase its aqueous solubility?
In Phase II Metabolism, which enzyme is responsible for conjugating a molecule of glucuronic acid to phenytoin to increase its aqueous solubility?
Which enzyme is primarily responsible for carrying out most oxidation reactions in drug metabolism?
Which enzyme is primarily responsible for carrying out most oxidation reactions in drug metabolism?
Where are cytochrome P450 enzymes primarily located within the cell?
Where are cytochrome P450 enzymes primarily located within the cell?
How does hyperthermia affect drug metabolism involving CYP450 enzymes?
How does hyperthermia affect drug metabolism involving CYP450 enzymes?
What effect does active liver disease have on drug metabolism involving CYP450 enzymes?
What effect does active liver disease have on drug metabolism involving CYP450 enzymes?
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