55 Questions
Which of the following is NOT a key process in the pharmacokinetics of a drug?
Excretion
What is the term used to describe the maximum concentration of a drug in the plasma?
C Max
What is the desired level of drug concentration for therapeutic dosing?
Minimal effective concentration
Which of the following is a main route of drug excretion?
Lungs
What determines the affinity of drugs for transporters in the nephron?
Polarity
What is drug clearance?
The measure of drug elimination efficiency
Which factor determines the magnitude of VD for drugs?
Affinity for tissue proteins
What does the term 'half-life' refer to?
The time for the drug concentration to halve
What does the slope of K denote in the concentration decay?
The order of the reaction
Which route of drug administration has an instant rate of absorption?
Intravenous bolus administration
Which type of drug administration shows a linear rate of absorption with time?
Intravenous infusion administration
Which process involves enzymatic conversion of a drug to a metabolite?
Drug metabolism
Which of the following is a factor that influences drug clearance?
Bioavailability
What is the volume of distribution (VD) in pharmacokinetics?
The volume into which a drug appears to be distributed with a concentration equal to that of plasma
Which form of the drug can cross over the porous capillary membranes?
Free drug
Which of the following is NOT a key process in the pharmacokinetics of a drug?
Absorption
What is the term used to describe the maximum concentration of a drug in the plasma?
Cmax
What does the term 'half-life' refer to?
The time it takes for a drug to be eliminated from the body
Which organ clearances are included in the calculation of drug clearance?
Hepatic, renal, and pulmonary
What is the formula for calculating drug clearance after intravenous dosing?
Dose divided by area under the curve
What is the definition of bioavailability?
Extent of absorption from the administration site to the measurement site
Which of the following is true about drug absorption via infusion?
The rate of absorption is independent of the amount of drug present
Which process makes a drug more water-soluble by oxidation, reduction, or hydrolysis?
Phase 1 metabolism
Which enzyme family is responsible for metabolizing a majority of drugs?
Cytochrome P450
Which of the following factors determines the volume of distribution (VD) of a drug?
Affinity for tissue proteins
What is the half-life of a drug?
The time it takes for the drug to be eliminated from the body
What does the slope of K represent in the concentration decay of a drug?
The order of the reaction
Which of the following factors can affect the extent of renal excretion of a drug?
The lipophilicity of the drug and the pH difference between urine and blood
What is the main function of organic anion transporters and organic cation transporters in the nephron?
Recognize weak acids and weak basic drugs for secretion into the lumen of the nephron
What is drug clearance?
A measure of the efficiency of drug elimination from the blood plasma
Which route of drug administration is dependent on the drug being absorbed into the circulatory system?
Oral administration
What is the term used to describe the peak concentration of a drug in the plasma?
Cmax
What is the term used to describe the phase in which drug levels reduce after reaching the peak concentration?
Elimination phase
Which route of drug administration has an absorption rate that is independent of the amount of drug present?
Intravenous administration
Which phase of drug metabolism involves the addition of a water-soluble molecule via synthetic conjugation?
Phase 2
Which enzyme family is responsible for the oxidation of drugs during phase 1 metabolism?
Cytochrome P450
Which of the following determines the magnitude of VD (volume of distribution) for drugs?
Affinity for tissue proteins
What does the term 'half-life' refer to in pharmacokinetics?
The time it takes for the drug concentration to halve
What does the slope of K denote in the concentration decay of a drug?
The order of the reaction
Which of the following is true about drug excretion?
Drug excretion can occur via the kidneys, hepatobiliary system, lungs, milk, and sweat.
What determines the affinity of drugs for transporters in the nephron?
The drug's polarity.
What is drug clearance?
The measure of the efficiency of drug elimination.
Which of the following is NOT included in the calculation of drug clearance?
Intestinal clearance
What is the formula for calculating drug clearance after oral dosing?
Clearance = F * Dose / Area under the curve
What is the volume of distribution (VD) in pharmacokinetics?
The volume into which a drug appears to be distributed with a concentration equal to that of plasma
What determines the magnitude of VD for drugs?
The drugs irascible affinity for tissue proteins versus plasma proteins
What is the concept of half-life?
The time it takes for the concentration of a drug to halve
What are the three types of reactions in concentration decay?
First, second, and zero order reactions
What does the slope of K denote in concentration decay?
The order of the reaction
What is the unit of volume for VD?
Volume per kilogram bodyweight
What is the term used to describe the maximum concentration of a drug in the plasma?
Peak concentration
What is the term used to describe the enzymatic conversion of a drug to a metabolite?
Phase 1 metabolism
What is the desired level of drug concentration for therapeutic dosing?
Therapeutic concentration
What is the route of drug administration that depends on absorption into the circulatory system?
Oral administration
What is the term used to describe the addition of a water-soluble molecule via synthetic conjugation in drug metabolism?
Conjugation
Test your knowledge on drug metabolism and excretion with this quiz. Explore the various enzymes involved in making drugs water-soluble for excretion and learn about the process of drug elimination by the body.
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