Drug Interactions of Suvorexant, Fluconazole, and Gaba-Ergics

<p>Fluoxetine</p> Signup and view all the answers

<p>8 mg</p> Signup and view all the answers

<p>3.5 mg</p> Signup and view all the answers

<p>Zaleplon is highly protein bound compared to zolpidem.</p> Signup and view all the answers

<p>It blocks the binding of orexin to the orexin A and orexin B receptors.</p> Signup and view all the answers

<p>Zaleplon</p> Signup and view all the answers

<p>Hypocretin</p> Signup and view all the answers

<p>Melatonin MT1 receptor</p> Signup and view all the answers

<p>Orexin receptor mutation</p> Signup and view all the answers

<p>2 hours (range 30 minutes to 6 hours)</p> Signup and view all the answers

<p>Zolpidem, zaleplon, and eszopiclone are excreted by the lungs.</p> Signup and view all the answers

<p>Narcolepsy</p> Signup and view all the answers

<p>3 weeks acutely, 3 months chronically</p> Signup and view all the answers

<p>Nausea</p> Signup and view all the answers

<p>Drugs that induce CYP3A4 will increase the blood levels of these hypnotics.</p> Signup and view all the answers

<p>They may lead to abnormal thinking and behavioral changes, including bizarre behavior and complex behaviors.</p> Signup and view all the answers

<p>Women are more sensitive to the effects of zolpidem and should be prescribed higher doses than men.</p> Signup and view all the answers

<p>Suvorexant is Schedule IV due to potential for abuse, but does not cause physical dependence.</p> Signup and view all the answers

<p>Sleep paralysis, the inability to move or speak, may occur for up to several hours during the sleep-wake transition with suvorexant.</p> Signup and view all the answers