Drug Interactions of Suvorexant, Fluconazole, and Gaba-Ergics

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What is the recommended initial dose of suvorexant for a patient not taking a moderate CYP3A4 inhibitor?

12.5 mg
10 mg (correct)
20 mg
5 mg

What is the maximum daily dose of suvorexant for a patient taking a moderate CYP3A4 inhibitor?

12.5 mg
20 mg
10 mg (correct)
5 mg

What is the recommended dose of zolpidem for older adults or women?

12.5 mg
20 mg
5 mg (correct)
10 mg

Which of the following is not a CYP3A4 inhibitor mentioned in the text?

Fluoxetine (A) Signup and view all the answers

What is the recommended dose of ramelteon?

8 mg (D) Signup and view all the answers

What is the maximum dose of zolpidem sublingual tablet for men?

3.5 mg (C) Signup and view all the answers

Which statement is true about nonbenzodiazepine hypnotics?

Zaleplon is highly protein bound compared to zolpidem. (D) Signup and view all the answers

What is the mechanism of action of suvorexant (Belsomra)?

It blocks the binding of orexin to the orexin A and orexin B receptors. (C) Signup and view all the answers

Which drug has the shortest half-life among the nonbenzodiazepine hypnotics mentioned?

Zaleplon (C) Signup and view all the answers

What is another name for orexin, which regulates wakefulness, arousal, and appetite?

Hypocretin (A) Signup and view all the answers

Which receptor does ramelteon (Rozerem) primarily act on?

Melatonin MT1 receptor (C) Signup and view all the answers

What is the potential cause of narcolepsy according to the text?

Orexin receptor mutation (D) Signup and view all the answers

What is the peak onset time of suvorexant when taken on an empty stomach?

2 hours (range 30 minutes to 6 hours) (B) Signup and view all the answers

Which of the following statements about the metabolism and excretion of nonbenzodiazepine hypnotics is incorrect?

Zolpidem, zaleplon, and eszopiclone are excreted by the lungs. (A) Signup and view all the answers

Which of the following is a contraindication for suvorexant?

Narcolepsy (D) Signup and view all the answers

What is the maximum recommended duration for using nonbenzodiazepine hypnotics without careful evaluation?

3 weeks acutely, 3 months chronically (D) Signup and view all the answers

Which of the following is a common adverse effect of nonbenzodiazepine hypnotics?

Nausea (D) Signup and view all the answers

Which of the following statements about the drug interactions of nonbenzodiazepine hypnotics is correct?

Drugs that induce CYP3A4 will increase the blood levels of these hypnotics. (D) Signup and view all the answers

Which of the following statements about the contraindications and precautions of nonbenzodiazepine hypnotics is correct?

They may lead to abnormal thinking and behavioral changes, including bizarre behavior and complex behaviors. (C) Signup and view all the answers

Which of the following statements about the adverse effects of nonbenzodiazepine hypnotics is incorrect?

Women are more sensitive to the effects of zolpidem and should be prescribed higher doses than men. (A) Signup and view all the answers

Which of the following statements about the scheduling and dependence potential of nonbenzodiazepine hypnotics is correct?

Suvorexant is Schedule IV due to potential for abuse, but does not cause physical dependence. (A) Signup and view all the answers

Which of the following statements about the adverse effects of nonbenzodiazepine hypnotics is correct?

Sleep paralysis, the inability to move or speak, may occur for up to several hours during the sleep-wake transition with suvorexant. (C) Signup and view all the answers