22 Questions
What is the recommended initial dose of suvorexant for a patient not taking a moderate CYP3A4 inhibitor?
10 mg
What is the maximum daily dose of suvorexant for a patient taking a moderate CYP3A4 inhibitor?
10 mg
What is the recommended dose of zolpidem for older adults or women?
5 mg
Which of the following is not a CYP3A4 inhibitor mentioned in the text?
Fluoxetine
What is the recommended dose of ramelteon?
8 mg
What is the maximum dose of zolpidem sublingual tablet for men?
3.5 mg
Which statement is true about nonbenzodiazepine hypnotics?
Zaleplon is highly protein bound compared to zolpidem.
What is the mechanism of action of suvorexant (Belsomra)?
It blocks the binding of orexin to the orexin A and orexin B receptors.
Which drug has the shortest half-life among the nonbenzodiazepine hypnotics mentioned?
Zaleplon
What is another name for orexin, which regulates wakefulness, arousal, and appetite?
Hypocretin
Which receptor does ramelteon (Rozerem) primarily act on?
Melatonin MT1 receptor
What is the potential cause of narcolepsy according to the text?
Orexin receptor mutation
What is the peak onset time of suvorexant when taken on an empty stomach?
2 hours (range 30 minutes to 6 hours)
Which of the following statements about the metabolism and excretion of nonbenzodiazepine hypnotics is incorrect?
Zolpidem, zaleplon, and eszopiclone are excreted by the lungs.
Which of the following is a contraindication for suvorexant?
Narcolepsy
What is the maximum recommended duration for using nonbenzodiazepine hypnotics without careful evaluation?
3 weeks acutely, 3 months chronically
Which of the following is a common adverse effect of nonbenzodiazepine hypnotics?
Nausea
Which of the following statements about the drug interactions of nonbenzodiazepine hypnotics is correct?
Drugs that induce CYP3A4 will increase the blood levels of these hypnotics.
Which of the following statements about the contraindications and precautions of nonbenzodiazepine hypnotics is correct?
They may lead to abnormal thinking and behavioral changes, including bizarre behavior and complex behaviors.
Which of the following statements about the adverse effects of nonbenzodiazepine hypnotics is incorrect?
Women are more sensitive to the effects of zolpidem and should be prescribed higher doses than men.
Which of the following statements about the scheduling and dependence potential of nonbenzodiazepine hypnotics is correct?
Suvorexant is Schedule IV due to potential for abuse, but does not cause physical dependence.
Which of the following statements about the adverse effects of nonbenzodiazepine hypnotics is correct?
Sleep paralysis, the inability to move or speak, may occur for up to several hours during the sleep-wake transition with suvorexant.
This quiz covers the drug interactions involving suvorexant, fluconazole, and gaba-ergics, focusing on how moderate CYP3A4 inhibitors and CYP2C9 inhibitors affect their levels. It also touches on the clinical use and dosing of these nonbenzodiazepine gaba-ergics for sedation purposes.
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