Drug Interactions and Dosage Adjustment Quiz
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Questions and Answers

What type of drug interactions can affect the processes of drug absorption, distribution, metabolism, and excretion?

  • Pharmacogenomic interactions
  • Pharmacodynamic interactions
  • Pharmacokinetic interactions (correct)
  • Pharmacological interactions

    • Which factor leads to increased absorption of weak acids in a basic environment?

  • Altered gut motility
  • Chelation mechanisms
  • Alkaline pH (correct)
  • Proton pump inhibitors

    • What effect does the induction of P-glycoprotein by rifampin have on the absorption of digoxin?

  • Faster elimination from the body
  • No effect on absorption
  • Increased absorption
  • Decreased absorption (correct)

    • Which drug interaction results in reduced absorption due to the formation of less soluble chelates?

    <p>Antacids with Al³+ and/or Mg²+</p> Signup and view all the answers

    What is the primary consequence of delaying gastric emptying on drug absorption?

    <p>Decreased rate of drug absorption</p> Signup and view all the answers

    How do weak bases behave in an acidic environment in terms of absorbability?

    <p>More absorbable</p> Signup and view all the answers

    What is the major enzyme responsible for the metabolism of 40% of drugs?

    <p>CYP3A4</p> Signup and view all the answers

    Enzyme induction can lead to increased drug metabolism by:

    <p>Enhancing enzyme activity</p> Signup and view all the answers

    Which drug inhibits the absorption of digoxin by interfering with P-glycoprotein?

    <p>Verapamil</p> Signup and view all the answers

    How long may enzyme induction take to develop and wear off?

    <p>3 weeks</p> Signup and view all the answers

    What effect does enzyme induction have on the metabolism of co-administered drugs?

    <p>Increases their metabolism</p> Signup and view all the answers

    Which enzyme is NOT a major metabolizing enzyme in phase 1 of drug metabolism?

    <p>CYP2D6</p> Signup and view all the answers

    What is the effect of rifampin on oral contraceptives, oral hypoglycemics, sildenafil, and tacrolimus/ciclosporin?

    <p>Increased hepatic metabolism via CYP3A4 induction, leading to accelerated elimination and reduced efficacy</p> Signup and view all the answers

    Which of the following statements about enzyme inhibition is correct?

    <p>It may occur within 2-3 days, leading to rapid development of toxicity</p> Signup and view all the answers

    What is the effect of macrolides on antihistamines like astemizole and sildenafil?

    <p>Decreased hepatic metabolism, leading to delayed elimination and increased toxicity</p> Signup and view all the answers

    How does a change in urinary pH affect the excretion of acidic and basic drugs?

    <p>Acidic drugs are excreted more in alkaline urine, and basic drugs are excreted more in acidic urine</p> Signup and view all the answers

    What is the effect of quinidine on drug excretion?

    <p>Increases tubular passive reabsorption, leading to increased risk of toxicity</p> Signup and view all the answers

    What is the effect of aspirin on drug excretion?

    <p>Decreases tubular passive reabsorption, leading to increased clearance</p> Signup and view all the answers

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