Podcast
Questions and Answers
What type of drug interactions can affect the processes of drug absorption, distribution, metabolism, and excretion?
What type of drug interactions can affect the processes of drug absorption, distribution, metabolism, and excretion?
- Pharmacogenomic interactions
- Pharmacodynamic interactions
- Pharmacokinetic interactions (correct)
- Pharmacological interactions
Which factor leads to increased absorption of weak acids in a basic environment?
Which factor leads to increased absorption of weak acids in a basic environment?
- Altered gut motility
- Chelation mechanisms
- Alkaline pH (correct)
- Proton pump inhibitors
What effect does the induction of P-glycoprotein by rifampin have on the absorption of digoxin?
What effect does the induction of P-glycoprotein by rifampin have on the absorption of digoxin?
- Faster elimination from the body
- No effect on absorption
- Increased absorption
- Decreased absorption (correct)
Which drug interaction results in reduced absorption due to the formation of less soluble chelates?
Which drug interaction results in reduced absorption due to the formation of less soluble chelates?
What is the primary consequence of delaying gastric emptying on drug absorption?
What is the primary consequence of delaying gastric emptying on drug absorption?
How do weak bases behave in an acidic environment in terms of absorbability?
How do weak bases behave in an acidic environment in terms of absorbability?
What is the major enzyme responsible for the metabolism of 40% of drugs?
What is the major enzyme responsible for the metabolism of 40% of drugs?
Enzyme induction can lead to increased drug metabolism by:
Enzyme induction can lead to increased drug metabolism by:
Which drug inhibits the absorption of digoxin by interfering with P-glycoprotein?
Which drug inhibits the absorption of digoxin by interfering with P-glycoprotein?
How long may enzyme induction take to develop and wear off?
How long may enzyme induction take to develop and wear off?
What effect does enzyme induction have on the metabolism of co-administered drugs?
What effect does enzyme induction have on the metabolism of co-administered drugs?
Which enzyme is NOT a major metabolizing enzyme in phase 1 of drug metabolism?
Which enzyme is NOT a major metabolizing enzyme in phase 1 of drug metabolism?
What is the effect of rifampin on oral contraceptives, oral hypoglycemics, sildenafil, and tacrolimus/ciclosporin?
What is the effect of rifampin on oral contraceptives, oral hypoglycemics, sildenafil, and tacrolimus/ciclosporin?
Which of the following statements about enzyme inhibition is correct?
Which of the following statements about enzyme inhibition is correct?
What is the effect of macrolides on antihistamines like astemizole and sildenafil?
What is the effect of macrolides on antihistamines like astemizole and sildenafil?
How does a change in urinary pH affect the excretion of acidic and basic drugs?
How does a change in urinary pH affect the excretion of acidic and basic drugs?
What is the effect of quinidine on drug excretion?
What is the effect of quinidine on drug excretion?
What is the effect of aspirin on drug excretion?
What is the effect of aspirin on drug excretion?
