Drug Interactions and Blood Glucose Quiz

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Questions and Answers

What is a potential effect of ACE inhibitors on blood glucose levels?

  • Increase insulin secretion
  • Inhibit hepatic glucose production (correct)
  • Delay insulin action
  • Block insulin secretion

Which medication is known to increase insulin secretion?

  • Fibrates
  • Alcohol
  • Phenobarbitone
  • Quinine (correct)

How do inducers of metabolism affect hypoglycemic drug concentration?

  • Have no effect
  • Increase it
  • Decrease it (correct)
  • Delay its action

Which drug is a known inhibitor of hepatic glucose production and release?

<p>Salicylates (D)</p> Signup and view all the answers

What is a potential effect of Rifampicin on sulfonylurea concentrations?

<p>Increase (C)</p> Signup and view all the answers

Which hormone is involved in the response to hypoglycemia by secretion of counter-regulatory hormones?

<p>Glucagon (D)</p> Signup and view all the answers

Which of the following medications is likely to raise blood glucose levels?

<p>Corticosteroids (D)</p> Signup and view all the answers

What is the probable mechanism by which thiazide diuretics affect blood glucose levels?

<p>Opposing insulin action (C)</p> Signup and view all the answers

Which of the following drug classes is least likely to lower blood glucose levels?

<p>Nifedipine (A)</p> Signup and view all the answers

How do phenothiazines mainly interact with blood glucose levels?

<p>By impairing insulin secretion (C)</p> Signup and view all the answers

What effect do oral contraceptive hormones have on blood glucose levels?

<p>They raise blood glucose levels by opposing insulin action (D)</p> Signup and view all the answers

In the context of drug interactions affecting blood glucose, which medication is most likely to have an adrenergic action contradicting insulin secretion?

<p>Clonidine (B)</p> Signup and view all the answers

What is the mechanism of action of sulfonylureas on pancreatic beta cells?

<p>Activation of KATP channels (D)</p> Signup and view all the answers

Which drug class is very similar to sulfonylureas in terms of mechanism and action?

<p>Meglitinides (C)</p> Signup and view all the answers

What is the clinical relevance of meglitinides compared to sulfonylureas?

<p>Longer half-life leading to less hypoglycemia (A)</p> Signup and view all the answers

Which ion channel is affected by sulfonylureas in the mechanism of action?

<ul> <li>ATP-sensitive K+ channel (D)</li> </ul> Signup and view all the answers

What is the effect of sulfonylureas on the influx of calcium in pancreatic beta cells?

<p>Increase influx of calcium (D)</p> Signup and view all the answers

How do meglitinides interact with sulfonylureas in terms of mechanism?

<p>Induce the opposite effect on ATP-sensitive K+ channels (D)</p> Signup and view all the answers

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