Drug Functions Quiz

Leucovorin = Increases binding affinity of 5-FU with thymidylate synthase Mechlorethamine = Treat Hodgkin’s lymphoma Cyclophosphamide = Mechlorethamine is precursor of this, causes DNA strand breaks Phosphoramide mustard = Active DNA alkylating metabolite of cyclophosphamide

Doxorubicin = Used with cyclophosphamide to treat breast cancer, topoisomerase inhibitor, cardiotoxic Cisplatin = Causes DNA strand breaks by creating cross-links Oxaliplatin = Same as cisplatin Irinotecan = Same as doxorubicin

Vincristine = Inhibits microtubule formation Paclitaxel = Stabilizes microtubules Capecitabine = 5-FU prodrug given orally Alectinib = EML4-ALK inhibitor, non small cell lung cancer

<p>Cetuximab = Anti-EGFR (HER1), used in conjunction with FOLFIRI for metastatic colon cancer Trastuzumab = Used with paclitaxel to improve prognosis for HER2+ breast cancer, binds to domain IV Dabrafenib = BRAF inhibitor Vemurafenib = BRAF inhibitor</p> Signup and view all the answers

<p>Ranibizumab = Bevacizumab analog used for wet macular degeneration Bevacizumab = Anti-VEGF Erlotinib = EGFR kinase inhibitor Panitumumab = Anti-EGFR, human form of cetuximab</p> Signup and view all the answers