Drug Elimination Rate and Clearance Quiz

Questions and Answers

What is the primary pharmacokinetic parameter for elimination?

Clearance

How is elimination rate constant related to clearance and volume of distribution?

The elimination rate constant is dependent on the clearance and volume of distribution.

Explain the relationship between elimination rate and plasma concentration in first-order elimination.

The rate of elimination is higher with higher plasma concentrations and lower with smaller plasma concentrations in first-order elimination.

How is elimination expressed using clearance and plasma concentration?

Elimination can be expressed as Rate of elimination = Cl x Cp, where Cl is total body clearance and Cp is plasma concentration. Signup and view all the answers

Describe the distribution of a drug in the body and its relationship with tissue/plasma concentration ratio.

As distribution proceeds, the tissue/plasma concentration ratio increases in each tissue until reaching equilibrium. Signup and view all the answers

What is a compartment in pharmacokinetics?

An imaginary unit consisting of tissues with similar drug uptake rates. Signup and view all the answers

Which tissues are usually considered well-perfused tissues in drug uptake?

Heart, Liver, Kidneys Signup and view all the answers

How are compartments selected for a particular drug?

Based on the behavior of plasma concentrations observed over time. Signup and view all the answers

What is the central compartment in pharmacokinetic models?

The compartment consisting of plasma and tissues that rapidly take up the drug. Signup and view all the answers

How many compartments are typically needed to create plasma concentration-time profiles?

Between one and three compartments. Signup and view all the answers