Drug Elimination and Special Carriers Quiz
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Questions and Answers

What branch of pharmacology deals with the undesirable effects of chemicals on living systems?

  • Botanical pharmacology
  • Toxicology (correct)
  • Ecosystem pharmacology
  • Medical pharmacology

What should all dietary supplements and health therapies meet in terms of standards?

  • No standards at all
  • Higher standards than conventional drugs
  • The same standards as conventional drugs (correct)
  • Lower standards than conventional drugs

Which area of study in pharmacology is focused on understanding the actions of drugs on individual organisms?

  • Environmental pharmacology
  • Ecosystem pharmacology
  • Medical pharmacology (correct)
  • Botanical pharmacology

What are the two large domains into which the actions of chemicals can be divided?

<p>Pharmacokinetics and pharmacodynamics (D)</p> Signup and view all the answers

How do the chemicals in botanicals differ from those in manufactured drugs?

<p>They contain more impurities (D)</p> Signup and view all the answers

What does pharmacodynamics primarily concern?

<p>Actions of chemicals on organisms (D)</p> Signup and view all the answers

What are the three main ways a drug should be eliminated from the body?

<p>Metabolic inactivation, excretion, facilitated diffusion (B)</p> Signup and view all the answers

Why are special carrier molecules important for some substances important for cell function?

<p>To facilitate movement through membranes (D)</p> Signup and view all the answers

What distinguishes special carrier molecules from passive diffusion?

<p>They are selective, saturable, and inhibitable (A)</p> Signup and view all the answers

Which family of transporters binds adenosine triphosphate (ATP)?

<p>ABC (ATP-binding cassette) family (B)</p> Signup and view all the answers

What is a common mechanism for drug permeation?

<p>Aqueous or lipid diffusion (A)</p> Signup and view all the answers

How can drug vehicles facilitate drug transport?

<p>By encapsulating the active agent in liposomes (B)</p> Signup and view all the answers

What type of substances are stored in membrane-bound vesicles in nerve endings to protect them from metabolic destruction?

<p>Neurotransmitter substances (D)</p> Signup and view all the answers

What determines the mobility of drug molecules in the medium of the diffusion path?

<p>Permeability coefficient (B)</p> Signup and view all the answers

Which form of a weak acid will be more lipid-soluble at acid pH?

<p>Uncharged form (D)</p> Signup and view all the answers

What is responsible for the secretion of many substances from cells?

<p>Exocytosis (A)</p> Signup and view all the answers

What does Fick's Law of Diffusion describe?

<p>Passive flux of molecules down a concentration gradient (D)</p> Signup and view all the answers

How does the lipid:aqueous partition coefficient impact the mobility of a drug?

<p>Determines how readily the drug enters the lipid membrane (C)</p> Signup and view all the answers

What is pharmacology defined as?

<p>The study of substances interacting with living systems through chemical processes (D)</p> Signup and view all the answers

Who were pioneers in developing experimental physiology and pharmacology in the late 18th and early 19th centuries?

<p>François Magendie and Claude Bernard (B)</p> Signup and view all the answers

Which type of molecules do small interfering RNAs (siRNAs) and micro-RNAs (miRNAs) target for therapeutic effects?

<p>Nucleic acids (B)</p> Signup and view all the answers

What do antisense oligonucleotides (ANOs) interfere with?

<p>Genes and RNA transcription (D)</p> Signup and view all the answers

What does pharmacology study in relation to living systems?

<p>Chemical interactions (B)</p> Signup and view all the answers

What is the main focus of pharmacology in relation to patients?

<p>Toxic effects on patients' regulatory processes (B)</p> Signup and view all the answers

What drives the movement of drug molecules according to Fick’s law?

<p>Concentration gradient (B)</p> Signup and view all the answers

Which factor influences the flux of charged drugs in addition to the concentration gradient?

<p>Membrane potential (B)</p> Signup and view all the answers

Where do drug molecules permeate across in the body, besides larger aqueous compartments?

<p>Epithelial membrane tight junctions (C)</p> Signup and view all the answers

Which transporter is found in the brain, testes, and some drug-resistant neoplastic cells?

<p>P-glycoprotein transporter (D)</p> Signup and view all the answers

What does the Henderson-Hasselbalch equation express for a weak acid or weak base?

<p>Lipid-soluble form to water-soluble form ratio (C)</p> Signup and view all the answers

How does the pH of the medium affect the movement of weak acids and weak bases between aqueous and lipid media?

<p>It affects the ability to move from aqueous to lipid or vice versa (D)</p> Signup and view all the answers

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