Drug Elimination and Special Carriers Quiz
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Questions and Answers

What branch of pharmacology deals with the undesirable effects of chemicals on living systems?

  • Botanical pharmacology
  • Toxicology (correct)
  • Ecosystem pharmacology
  • Medical pharmacology
  • What should all dietary supplements and health therapies meet in terms of standards?

  • No standards at all
  • Higher standards than conventional drugs
  • The same standards as conventional drugs (correct)
  • Lower standards than conventional drugs
  • Which area of study in pharmacology is focused on understanding the actions of drugs on individual organisms?

  • Environmental pharmacology
  • Ecosystem pharmacology
  • Medical pharmacology (correct)
  • Botanical pharmacology
  • What are the two large domains into which the actions of chemicals can be divided?

    <p>Pharmacokinetics and pharmacodynamics</p> Signup and view all the answers

    How do the chemicals in botanicals differ from those in manufactured drugs?

    <p>They contain more impurities</p> Signup and view all the answers

    What does pharmacodynamics primarily concern?

    <p>Actions of chemicals on organisms</p> Signup and view all the answers

    What are the three main ways a drug should be eliminated from the body?

    <p>Metabolic inactivation, excretion, facilitated diffusion</p> Signup and view all the answers

    Why are special carrier molecules important for some substances important for cell function?

    <p>To facilitate movement through membranes</p> Signup and view all the answers

    What distinguishes special carrier molecules from passive diffusion?

    <p>They are selective, saturable, and inhibitable</p> Signup and view all the answers

    Which family of transporters binds adenosine triphosphate (ATP)?

    <p>ABC (ATP-binding cassette) family</p> Signup and view all the answers

    What is a common mechanism for drug permeation?

    <p>Aqueous or lipid diffusion</p> Signup and view all the answers

    How can drug vehicles facilitate drug transport?

    <p>By encapsulating the active agent in liposomes</p> Signup and view all the answers

    What type of substances are stored in membrane-bound vesicles in nerve endings to protect them from metabolic destruction?

    <p>Neurotransmitter substances</p> Signup and view all the answers

    What determines the mobility of drug molecules in the medium of the diffusion path?

    <p>Permeability coefficient</p> Signup and view all the answers

    Which form of a weak acid will be more lipid-soluble at acid pH?

    <p>Uncharged form</p> Signup and view all the answers

    What is responsible for the secretion of many substances from cells?

    <p>Exocytosis</p> Signup and view all the answers

    What does Fick's Law of Diffusion describe?

    <p>Passive flux of molecules down a concentration gradient</p> Signup and view all the answers

    How does the lipid:aqueous partition coefficient impact the mobility of a drug?

    <p>Determines how readily the drug enters the lipid membrane</p> Signup and view all the answers

    What is pharmacology defined as?

    <p>The study of substances interacting with living systems through chemical processes</p> Signup and view all the answers

    Who were pioneers in developing experimental physiology and pharmacology in the late 18th and early 19th centuries?

    <p>François Magendie and Claude Bernard</p> Signup and view all the answers

    Which type of molecules do small interfering RNAs (siRNAs) and micro-RNAs (miRNAs) target for therapeutic effects?

    <p>Nucleic acids</p> Signup and view all the answers

    What do antisense oligonucleotides (ANOs) interfere with?

    <p>Genes and RNA transcription</p> Signup and view all the answers

    What does pharmacology study in relation to living systems?

    <p>Chemical interactions</p> Signup and view all the answers

    What is the main focus of pharmacology in relation to patients?

    <p>Toxic effects on patients' regulatory processes</p> Signup and view all the answers

    What drives the movement of drug molecules according to Fick’s law?

    <p>Concentration gradient</p> Signup and view all the answers

    Which factor influences the flux of charged drugs in addition to the concentration gradient?

    <p>Membrane potential</p> Signup and view all the answers

    Where do drug molecules permeate across in the body, besides larger aqueous compartments?

    <p>Epithelial membrane tight junctions</p> Signup and view all the answers

    Which transporter is found in the brain, testes, and some drug-resistant neoplastic cells?

    <p>P-glycoprotein transporter</p> Signup and view all the answers

    What does the Henderson-Hasselbalch equation express for a weak acid or weak base?

    <p>Lipid-soluble form to water-soluble form ratio</p> Signup and view all the answers

    How does the pH of the medium affect the movement of weak acids and weak bases between aqueous and lipid media?

    <p>It affects the ability to move from aqueous to lipid or vice versa</p> Signup and view all the answers

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