Drug-Drug Interactions Quiz

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Questions and Answers

What is the primary mechanism by which antibiotic medications interact with warfarin to increase the risk of major bleeding?

  • Enhanced production of platelets
  • Increase in sensitivity of hepatic receptors to warfarin
  • Disruption of intestinal flora that synthesize Vitamin K (correct)
  • Inhibition of Cytochrome p450 isozymes which metabolize warfarin

What is the preferred range of INR levels for a patient on anticoagulation therapy?

  • 3 - 4
  • 1.5 - 2.5
  • 2 - 3 (correct)
  • 2.5 - 3.5

What is the preferred range of INR levels for a patient on anticoagulation therapy?

  • 0.5 - 1.5
  • 2 - 3 (correct)
  • 3.5 - 4.5
  • 5 - 6

Which of the following antibiotic medications is NOT associated with an increased risk of bleeding when interacting with warfarin?

<p>Amoxicillin (B)</p> Signup and view all the answers

What type of medication are Azole Antifungals (e.g., Fluconazole, Itraconazole) and Miconazole?

<p>Antifungal medication (B)</p> Signup and view all the answers

Which of the following mechanisms is NOT a primary reason for the interaction between antibiotic medications and warfarin, leading to an increased risk of major bleeding?

<p>Enhancement of platelet aggregation due to antibiotic medications. (D)</p> Signup and view all the answers

What is the purpose of monitoring INR closely during and after antimicrobial treatment?

<p>To manage anticoagulant therapy (A)</p> Signup and view all the answers

What is the purpose of adjusting the dose of warfarin based on periodic blood tests?

<p>To maintain clotting time within a target range. (D)</p> Signup and view all the answers

Which class of medication do Azole Antifungals (e.g., Fluconazole, Itraconazole) and Miconazole belong to?

<p>Antifungals (C)</p> Signup and view all the answers

What is the primary effect of monitoring INR closely during and after antimicrobial treatment?

<p>To ensure appropriate anticoagulation therapy. (A)</p> Signup and view all the answers

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