Questions and Answers
What are the three primary categories of dosage forms mentioned?
Which of the following is an example of a solid dosage form?
Which dosage form is primarily characterized by a viscous consistency?
What is the main purpose of dosage forms in drug delivery systems?
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Which type of dosage form is likely to provide the fastest onset of action?
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What distinguishes semi-solid dosage forms from liquids?
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Which of the following would NOT be classified as a liquid dosage form?
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What role does the definition of terms play in understanding drug delivery systems?
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What characterizes modified-release tablets?
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Which of the following examples are classified as modified-release tablets?
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What distinguishes bimodal release tablets from standard ones?
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What is a common characteristic of the liquid form of modified-release tablets?
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How does the release timing differ in modified-release tablets compared to immediate-release tablets?
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Which factor may influence the release of medication from modified-release tablets?
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What type of medication is Clarinex (Loratidine) classified under in relation to modified-release tablets?
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Which of the following is NOT a feature of modified-release tablets?
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What defines granules in the context of powder preparation?
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Which mesh sizes do granules specifically pass through?
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What is one of the advantages of using granules?
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What happens if there are too many good granules in a mixture?
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What is the ideal ratio of good granules to fine granules?
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Which of the following describes fine granules?
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What does an outer binder-rich layer in granules facilitate?
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What characteristic is associated with granules that prevents segregation?
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What defines colonic tablets in drug delivery?
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What is the purpose of gastroretentive tablets?
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Which type of kinetics is maintained by gastroretentive tablets for therapeutic plasma concentration?
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What characterizes the release mechanism of first-order kinetics?
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Which medication is an example of a drug delivered through colonic tablets?
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What is NOT a characteristic of gastroretentive tablets?
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In which dosage form is drug action concentrated in a specific body tissue or site?
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Which of the following terms refers to drugs that have a consistent release rate?
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What is a primary characteristic of medicated powders?
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Which of the following is NOT a common use for medicated powders?
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What is a disadvantage of using medicated powders compared to other dosage forms?
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Which benefit of medicated powders contributes to their effective dosage management?
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How can medicated powders be administered?
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Study Notes
Drug Delivery Systems and Dosage Forms
- Drug delivery systems encompass various forms for medication administration, optimizing therapeutic effects while minimizing side effects.
Introduction
- Dosage forms vary in structure and delivery method, including solid, liquid, and semi-solid formulations.
Solid Dosage Forms
- Comprised of finely powdered mixtures either used internally (oral powders) or externally (topical powders).
- Compression of powders into tablets or encapsulation into capsules is common.
- Granules formed from smaller particles, improving dosage stability and flowability.
Granules
- Prepared agglomerates passing through size 4-12 mesh.
- Good granules: pass through #20 but not #40; Fine granules: pass through #40.
- Ideal ratio for effective granule composition is 90% Good and 10% Fine to balance voids and interparticulate friction.
Modified-Release Tablets
- Disintegrate without special rate-controlling agents, serving as a benchmark for others.
- Examples include compositions for anti-psychotics and antiemetics, liquefying quickly for ease of swallowing.
- Time-based or environment-based drug release mechanisms, including two-layer systems for immediate and extended release.
Types of Tablets
- Modified-release tablets aim at localized drug delivery for absorption.
- Colonic tablets target the colon directly, maintaining effectiveness without dispersion in the gastrointestinal tract.
- Gastroretentive tablets remain significantly in the stomach, providing prolonged drug release for an extended therapeutic range (8-12 hours).
Kinetics in Drug Release
- Zero-order kinetics maintain constant plasma concentration, suitable for transdermal or oral routes.
- First-order kinetics promotes gradually decreasing drug concentration, primarily oral routes.
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Description
Explore the various drug delivery systems and dosage forms used in medication administration. This quiz covers solid, liquid, and semi-solid formulations, focusing on their structures, preparation, and effectiveness. Understand the importance of granules and modified-release tablets in optimizing therapeutic outcomes.
