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Questions and Answers
What are the three primary categories of dosage forms mentioned?
What are the three primary categories of dosage forms mentioned?
- Semi-solid, Solid, Gel
- Liquid, Gas, Cream
- Solid, Liquid, Gas
- Solid, Liquid, Semi-solid (correct)
Which of the following is an example of a solid dosage form?
Which of the following is an example of a solid dosage form?
- Syrup
- Cream
- Tablet (correct)
- Suspension
Which dosage form is primarily characterized by a viscous consistency?
Which dosage form is primarily characterized by a viscous consistency?
- Gel (correct)
- Tablet
- Syrup
- Powder
What is the main purpose of dosage forms in drug delivery systems?
What is the main purpose of dosage forms in drug delivery systems?
Which type of dosage form is likely to provide the fastest onset of action?
Which type of dosage form is likely to provide the fastest onset of action?
What distinguishes semi-solid dosage forms from liquids?
What distinguishes semi-solid dosage forms from liquids?
Which of the following would NOT be classified as a liquid dosage form?
Which of the following would NOT be classified as a liquid dosage form?
What role does the definition of terms play in understanding drug delivery systems?
What role does the definition of terms play in understanding drug delivery systems?
What characterizes modified-release tablets?
What characterizes modified-release tablets?
Which of the following examples are classified as modified-release tablets?
Which of the following examples are classified as modified-release tablets?
What distinguishes bimodal release tablets from standard ones?
What distinguishes bimodal release tablets from standard ones?
What is a common characteristic of the liquid form of modified-release tablets?
What is a common characteristic of the liquid form of modified-release tablets?
How does the release timing differ in modified-release tablets compared to immediate-release tablets?
How does the release timing differ in modified-release tablets compared to immediate-release tablets?
Which factor may influence the release of medication from modified-release tablets?
Which factor may influence the release of medication from modified-release tablets?
What type of medication is Clarinex (Loratidine) classified under in relation to modified-release tablets?
What type of medication is Clarinex (Loratidine) classified under in relation to modified-release tablets?
Which of the following is NOT a feature of modified-release tablets?
Which of the following is NOT a feature of modified-release tablets?
What defines granules in the context of powder preparation?
What defines granules in the context of powder preparation?
Which mesh sizes do granules specifically pass through?
Which mesh sizes do granules specifically pass through?
What is one of the advantages of using granules?
What is one of the advantages of using granules?
What happens if there are too many good granules in a mixture?
What happens if there are too many good granules in a mixture?
What is the ideal ratio of good granules to fine granules?
What is the ideal ratio of good granules to fine granules?
Which of the following describes fine granules?
Which of the following describes fine granules?
What does an outer binder-rich layer in granules facilitate?
What does an outer binder-rich layer in granules facilitate?
What characteristic is associated with granules that prevents segregation?
What characteristic is associated with granules that prevents segregation?
What defines colonic tablets in drug delivery?
What defines colonic tablets in drug delivery?
What is the purpose of gastroretentive tablets?
What is the purpose of gastroretentive tablets?
Which type of kinetics is maintained by gastroretentive tablets for therapeutic plasma concentration?
Which type of kinetics is maintained by gastroretentive tablets for therapeutic plasma concentration?
What characterizes the release mechanism of first-order kinetics?
What characterizes the release mechanism of first-order kinetics?
Which medication is an example of a drug delivered through colonic tablets?
Which medication is an example of a drug delivered through colonic tablets?
What is NOT a characteristic of gastroretentive tablets?
What is NOT a characteristic of gastroretentive tablets?
In which dosage form is drug action concentrated in a specific body tissue or site?
In which dosage form is drug action concentrated in a specific body tissue or site?
Which of the following terms refers to drugs that have a consistent release rate?
Which of the following terms refers to drugs that have a consistent release rate?
What is a primary characteristic of medicated powders?
What is a primary characteristic of medicated powders?
Which of the following is NOT a common use for medicated powders?
Which of the following is NOT a common use for medicated powders?
What is a disadvantage of using medicated powders compared to other dosage forms?
What is a disadvantage of using medicated powders compared to other dosage forms?
Which benefit of medicated powders contributes to their effective dosage management?
Which benefit of medicated powders contributes to their effective dosage management?
How can medicated powders be administered?
How can medicated powders be administered?
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Study Notes
Drug Delivery Systems and Dosage Forms
- Drug delivery systems encompass various forms for medication administration, optimizing therapeutic effects while minimizing side effects.
Introduction
- Dosage forms vary in structure and delivery method, including solid, liquid, and semi-solid formulations.
Solid Dosage Forms
- Comprised of finely powdered mixtures either used internally (oral powders) or externally (topical powders).
- Compression of powders into tablets or encapsulation into capsules is common.
- Granules formed from smaller particles, improving dosage stability and flowability.
Granules
- Prepared agglomerates passing through size 4-12 mesh.
- Good granules: pass through #20 but not #40; Fine granules: pass through #40.
- Ideal ratio for effective granule composition is 90% Good and 10% Fine to balance voids and interparticulate friction.
Modified-Release Tablets
- Disintegrate without special rate-controlling agents, serving as a benchmark for others.
- Examples include compositions for anti-psychotics and antiemetics, liquefying quickly for ease of swallowing.
- Time-based or environment-based drug release mechanisms, including two-layer systems for immediate and extended release.
Types of Tablets
- Modified-release tablets aim at localized drug delivery for absorption.
- Colonic tablets target the colon directly, maintaining effectiveness without dispersion in the gastrointestinal tract.
- Gastroretentive tablets remain significantly in the stomach, providing prolonged drug release for an extended therapeutic range (8-12 hours).
Kinetics in Drug Release
- Zero-order kinetics maintain constant plasma concentration, suitable for transdermal or oral routes.
- First-order kinetics promotes gradually decreasing drug concentration, primarily oral routes.
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