Drug Delivery Systems and Dosage Forms
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Questions and Answers

What are the three primary categories of dosage forms mentioned?

  • Semi-solid, Solid, Gel
  • Liquid, Gas, Cream
  • Solid, Liquid, Gas
  • Solid, Liquid, Semi-solid (correct)

    • Which of the following is an example of a solid dosage form?

  • Syrup
  • Cream
  • Tablet (correct)
  • Suspension

    • Which dosage form is primarily characterized by a viscous consistency?

  • Gel (correct)
  • Tablet
  • Syrup
  • Powder

    • What is the main purpose of dosage forms in drug delivery systems?

    <p>To ensure accurate dosing and effective delivery</p> Signup and view all the answers

    Which type of dosage form is likely to provide the fastest onset of action?

    <p>Liquid</p> Signup and view all the answers

    What distinguishes semi-solid dosage forms from liquids?

    <p>Their viscous and cohesive nature</p> Signup and view all the answers

    Which of the following would NOT be classified as a liquid dosage form?

    <p>Ointment</p> Signup and view all the answers

    What role does the definition of terms play in understanding drug delivery systems?

    <p>It standardizes communications and enhances comprehension</p> Signup and view all the answers

    What characterizes modified-release tablets?

    <p>They disintegrate and release medication without special rate-controlling mechanisms.</p> Signup and view all the answers

    Which of the following examples are classified as modified-release tablets?

    <p>Risperidone</p> Signup and view all the answers

    What distinguishes bimodal release tablets from standard ones?

    <p>One layer releases immediately while the other releases later.</p> Signup and view all the answers

    What is a common characteristic of the liquid form of modified-release tablets?

    <p>It liquefies in the tongue within 15 seconds to 1 minute.</p> Signup and view all the answers

    How does the release timing differ in modified-release tablets compared to immediate-release tablets?

    <p>Modified-release tablets release medication gradually over time.</p> Signup and view all the answers

    Which factor may influence the release of medication from modified-release tablets?

    <p>The environment or timing of ingestion.</p> Signup and view all the answers

    What type of medication is Clarinex (Loratidine) classified under in relation to modified-release tablets?

    <p>Antihistamines</p> Signup and view all the answers

    Which of the following is NOT a feature of modified-release tablets?

    <p>They provide a single high dose immediately.</p> Signup and view all the answers

    What defines granules in the context of powder preparation?

    <p>Prepared agglomerates of smaller particles of powder</p> Signup and view all the answers

    Which mesh sizes do granules specifically pass through?

    <p>4-12 mesh</p> Signup and view all the answers

    What is one of the advantages of using granules?

    <p>Improves flowability of the powder</p> Signup and view all the answers

    What happens if there are too many good granules in a mixture?

    <p>Creation of voids</p> Signup and view all the answers

    What is the ideal ratio of good granules to fine granules?

    <p>90% Good and 10% Fine</p> Signup and view all the answers

    Which of the following describes fine granules?

    <p>Pass through #40</p> Signup and view all the answers

    What does an outer binder-rich layer in granules facilitate?

    <p>Improved flowability and compaction</p> Signup and view all the answers

    What characteristic is associated with granules that prevents segregation?

    <p>Stability and wettability</p> Signup and view all the answers

    What defines colonic tablets in drug delivery?

    <p>They deliver drugs specifically into the colon without dilution.</p> Signup and view all the answers

    What is the purpose of gastroretentive tablets?

    <p>To maintain drug presence in the stomach for extended periods.</p> Signup and view all the answers

    Which type of kinetics is maintained by gastroretentive tablets for therapeutic plasma concentration?

    <p>Zero-order kinetics</p> Signup and view all the answers

    What characterizes the release mechanism of first-order kinetics?

    <p>Release rate depends on the drug concentration.</p> Signup and view all the answers

    Which medication is an example of a drug delivered through colonic tablets?

    <p>Mesalamine</p> Signup and view all the answers

    What is NOT a characteristic of gastroretentive tablets?

    <p>They are rapidly absorbed in the intestines.</p> Signup and view all the answers

    In which dosage form is drug action concentrated in a specific body tissue or site?

    <p>Modified-release tablets</p> Signup and view all the answers

    Which of the following terms refers to drugs that have a consistent release rate?

    <p>Zero-order kinetics drugs</p> Signup and view all the answers

    What is a primary characteristic of medicated powders?

    <p>They consist of finely divided particles in dry form.</p> Signup and view all the answers

    Which of the following is NOT a common use for medicated powders?

    <p>Preparation of intravenous solutions.</p> Signup and view all the answers

    What is a disadvantage of using medicated powders compared to other dosage forms?

    <p>Their use is limited as other dosage forms are more common.</p> Signup and view all the answers

    Which benefit of medicated powders contributes to their effective dosage management?

    <p>Readily adjustable dose.</p> Signup and view all the answers

    How can medicated powders be administered?

    <p>Dissolved or suspended in a solvent.</p> Signup and view all the answers

    Study Notes

    Drug Delivery Systems and Dosage Forms

    • Drug delivery systems encompass various forms for medication administration, optimizing therapeutic effects while minimizing side effects.

    Introduction

    • Dosage forms vary in structure and delivery method, including solid, liquid, and semi-solid formulations.

    Solid Dosage Forms

    • Comprised of finely powdered mixtures either used internally (oral powders) or externally (topical powders).
    • Compression of powders into tablets or encapsulation into capsules is common.
    • Granules formed from smaller particles, improving dosage stability and flowability.

    Granules

    • Prepared agglomerates passing through size 4-12 mesh.
    • Good granules: pass through #20 but not #40; Fine granules: pass through #40.
    • Ideal ratio for effective granule composition is 90% Good and 10% Fine to balance voids and interparticulate friction.

    Modified-Release Tablets

    • Disintegrate without special rate-controlling agents, serving as a benchmark for others.
    • Examples include compositions for anti-psychotics and antiemetics, liquefying quickly for ease of swallowing.
    • Time-based or environment-based drug release mechanisms, including two-layer systems for immediate and extended release.

    Types of Tablets

    • Modified-release tablets aim at localized drug delivery for absorption.
    • Colonic tablets target the colon directly, maintaining effectiveness without dispersion in the gastrointestinal tract.
    • Gastroretentive tablets remain significantly in the stomach, providing prolonged drug release for an extended therapeutic range (8-12 hours).

    Kinetics in Drug Release

    • Zero-order kinetics maintain constant plasma concentration, suitable for transdermal or oral routes.
    • First-order kinetics promotes gradually decreasing drug concentration, primarily oral routes.

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    Drug Delivery Systems & Dosage Forms PDF

    Description

    Explore the various drug delivery systems and dosage forms used in medication administration. This quiz covers solid, liquid, and semi-solid formulations, focusing on their structures, preparation, and effectiveness. Understand the importance of granules and modified-release tablets in optimizing therapeutic outcomes.

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