Drug Clearance Quiz

Drug Clearance

• Drug clearance is the process by which a drug is removed from the body, involving the elimination of the drug from the bloodstream and its excretion from the body.

Primary Organ for Drug Excretion

• The primary organ responsible for excreting drugs from the body is the liver.

Elimination in Drug Clearance

• Elimination, in the context of drug clearance, refers to the irreversible removal of a drug from the body, either through metabolism or excretion.

Volume of Plasma Cleared

• The volume of plasma cleared of a drug per unit time is known as clearance.

Clinically Relevant Organs for Drug Clearance

• The most clinically relevant organs in pharmacokinetics for drug clearance are the liver and kidneys.

Definition of Drug Clearance

• Drug clearance is defined as the rate at which a drug is removed from the body, expressed in units of volume per unit time (e.g., mL/min).

Relationship between Clearance, Rate of Elimination, and Concentration

• The rate of elimination is directly proportional to the concentration of the drug in plasma, and clearance is a constant that describes the fraction of the volume of plasma that is cleared of the drug per unit time.

Significance of Drug Clearance

• Drug clearance is a critical parameter in pharmacokinetics, as it determines the duration and intensity of a drug's effect, and helps to predict the dosage and dosing frequency required to achieve a therapeutic response.

Organs Responsible for Drug Clearance and Elimination

• The liver and kidneys are primarily responsible for drug clearance and elimination in pharmacokinetics, with the liver responsible for metabolism and the kidneys responsible for excretion.

Role of the Urinary System

• The urinary system plays a significant role in drug elimination, as it is responsible for excreting the drug or its metabolites from the body through urine.