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Questions and Answers
Which of these are examples of biguanides?
Which of these are examples of biguanides?
- Insulin
- Glyburide
- Sitagliptin
- Metformin (Glucophage) (correct)
What are biguanides used to treat?
What are biguanides used to treat?
Type 2 diabetes
What is the main pharmacological action of biguanides?
What is the main pharmacological action of biguanides?
Reduces production of glucose within the liver through suppression of glucogenesis.
Common side effects of biguanides include ______.
Common side effects of biguanides include ______.
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Concurrent use of iodine-containing contrast for diagnostic tests may result in acute renal failure when using biguanides.
Concurrent use of iodine-containing contrast for diagnostic tests may result in acute renal failure when using biguanides.
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Alcohol decreases the risk of lactic acidosis when taking biguanides.
Alcohol decreases the risk of lactic acidosis when taking biguanides.
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Study Notes
Biguanides Overview
- Biguanides are a class of oral medications used to treat type 2 diabetes, primarily represented by metformin (Glucophage).
- These drugs impact glucose production from digestion.
Pharmacological Action
- Biguanides reduce liver glucose production through the suppression of gluconeogenesis.
Side Effects
- Common side effects include:
- Metallic taste
- Diarrhea
- Anorexia
- Nausea
- Vomiting
- Vitamin B-12 and folic acid deficiencies
- Altered absorption of nutrients
Nursing Implications
- Use of iodine-containing contrast agents in diagnostic tests may lead to acute renal failure when combined with biguanides.
Important Interactions
- Alcohol consumption with biguanides elevates the risk of lactic acidosis, a condition of excess lactic acid in the body.
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