Droperidol (Inapsine®) Actions
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Questions and Answers

Which patient population should droperidol be avoided in?

  • Patients with prolonged QTc interval
  • Patients with Parkinson's disease
  • Patients taking other QTc prolonging agents
  • All of the above (correct)

    • How does the concomitant administration of phenothiazines affect the ventilatory effects of opioids?

  • The ventilatory effects of opioids are exaggerated (correct)
  • The ventilatory effects of opioids are decreased
  • The ventilatory effects of opioids are unchanged
  • The ventilatory effects of opioids are unpredictable

    • What adverse effect of droperidol is mentioned in the text?

  • Increased risk of neuroleptic malignant syndrome
  • Increased risk of serotonin syndrome
  • Increased incidence of hypotension (correct)
  • Increased risk of extrapyramidal symptoms

    • Which of the following is recommended when using phenothiazines in the perioperative setting?

    <p>Use glycopyrrolate if an anticholinergic agent is needed</p> Signup and view all the answers

    How does the concomitant administration of phenothiazines and opioids affect the analgesic effects of the opioids?

    <p>The analgesic effects of opioids are potentiated</p> Signup and view all the answers

    Which of the following best describes the proposed mechanism of action of antidepressants?

    <p>Inhibition of neurotransmitter reuptake</p> Signup and view all the answers

    Which of the following adverse effects is most commonly associated with droperidol?

    <p>Postoperative hallucinatory episodes</p> Signup and view all the answers

    In neuroleptanalgesia, which neurotransmitter does droperidol primarily block at the carotid body to augment the ventilatory response?

    <p>Dopamine</p> Signup and view all the answers

    Which of the following statements regarding droperidol-fentanyl combination therapy is TRUE?

    <p>It is not associated with enhanced ventilatory depression compared to either drug alone</p> Signup and view all the answers

    Which of the following adverse effects has been reported when droperidol is given to pheochromocytoma patients?

    <p>Hypertension</p> Signup and view all the answers

    What rare adverse effect can occur at low or high doses of droperidol, as indicated by a black-box warning?

    <p>QT interval prolongation and/or torsade de pointes</p> Signup and view all the answers

    When combined with droperidol, which type of drugs generally have additive or potentiating effects, leading to CNS depression?

    <p>Central Nervous System (CNS) depressant drugs</p> Signup and view all the answers

    What is the primary side effect associated with clozapine use?

    <p>Agranulocytosis</p> Signup and view all the answers

    What is a common adverse reaction to haloperidol use?

    <p>Bronchospasm</p> Signup and view all the answers

    Which antipsychotic agent has a high risk of extrapyramidal symptoms (EPS)?

    <p>Risperidone</p> Signup and view all the answers

    What is the mechanism of action of droperidol in the prevention of nausea and vomiting?

    <p>Blocking dopamine receptors in the chemoreceptor trigger zone</p> Signup and view all the answers

    Which drug class should be used cautiously with droperidol due to a potential interaction affecting plasma concentrations?

    <p>Beta-blockers</p> Signup and view all the answers

    What is the primary action of droperidol on the central nervous system?

    <p>Producing sedation and tranquilization</p> Signup and view all the answers

    Which of the following symptoms is NOT commonly associated with increased prolactin levels?

    <p>Venous Thromboembolism</p> Signup and view all the answers

    What condition is characterized by ANC levels below 500/mm3?

    <p>Leukopenia</p> Signup and view all the answers

    Droperidol is safe to use in patients with prolonged QTc interval.

    <p>False</p> Signup and view all the answers

    Combining droperidol with agents that prolong the QTc interval is safe.

    <p>False</p> Signup and view all the answers

    Droperidol is recommended for patients with Parkinson's disease.

    <p>False</p> Signup and view all the answers

    Phenothiazines enhance the effects of CNS depressant drugs like stimulants.

    <p>False</p> Signup and view all the answers

    The analgesic effects of opioids are decreased when combined with phenothiazines.

    <p>False</p> Signup and view all the answers

    Phenothiazines are commonly used as anti-emetic agents due to their low incidence of adverse effects.

    <p>False</p> Signup and view all the answers

    Droperidol and metoclopramide should not be co-administered due to their dopaminergic blockade properties.

    <p>True</p> Signup and view all the answers

    Using ketamine and meperidine concurrently with phenothiazines is safe.

    <p>False</p> Signup and view all the answers

    Glycopyrrolate should not be used as an anticholinergic agent when phenothiazines are administered.

    <p>False</p> Signup and view all the answers

    Phenothiazines are commonly recommended for patients with Parkinson's disease.

    <p>False</p> Signup and view all the answers

    Droperidol is ______ in patients with prolonged QTc interval.

    <p>contraindicated</p> Signup and view all the answers

    Droperidol should not be administered to patients with ______ disease.

    <p>parkinson's</p> Signup and view all the answers

    Do not use droperidol with other agents that also ______ the QTc interval.

    <p>prolong</p> Signup and view all the answers

    Avoid the use of ______ & meperidine when administering phenothiazines.

    <p>ketamine</p> Signup and view all the answers

    In general, phenothiazine agents are not used as ______ agents due to their higher incidence of adverse effects.

    <p>anti-emetic</p> Signup and view all the answers

    What is the primary mechanism of action of droperidol that allows it to be used as an anti-emetic agent?

    <p>Droperidol is a potent dopamine antagonist, and its anti-emetic effects are primarily mediated by blocking dopamine receptors in the chemoreceptor trigger zone of the area postrema in the brain.</p> Signup and view all the answers

    Explain the contraindication for using droperidol in patients with prolonged QTc interval and the potential consequence of ignoring this contraindication.

    <p>Droperidol is contraindicated in patients with prolonged QTc interval (QTc &gt; 440 ms in men, 450 ms in women) due to its potential to further prolong the QTc interval and increase the risk of developing torsades de pointes, a potentially fatal ventricular arrhythmia.</p> Signup and view all the answers

    Why is droperidol contraindicated in patients with Parkinson's disease, and what alternative agents could be considered in this patient population?

    <p>Droperidol is contraindicated in patients with Parkinson's disease because it is a potent dopamine antagonist, and Parkinson's disease is characterized by a deficiency of dopamine in the central nervous system. Alternative agents that could be considered include other antiemetics like ondansetron or granisetron that do not have dopaminergic effects.</p> Signup and view all the answers

    Discuss the potential drug-drug interactions between droperidol and other agents that prolong the QTc interval, and the importance of avoiding such combinations.

    <p>Droperidol should not be used concomitantly with other agents that also prolong the QTc interval, as this can lead to an additive or synergistic effect on QTc prolongation, further increasing the risk of developing torsades de pointes and other ventricular arrhythmias. Avoiding such combinations is crucial to mitigate the risk of potentially fatal cardiac complications.</p> Signup and view all the answers

    Explain the potential impact of concomitant administration of phenothiazines and opioids on the ventilatory effects and analgesic effects of opioids.

    <p>The concomitant administration of phenothiazines and opioids can exaggerate the ventilatory depressant effects of opioids, potentially leading to respiratory depression. Additionally, the analgesic effects of opioids are potentiated when combined with phenothiazines, potentially increasing the risk of opioid-related adverse effects.</p> Signup and view all the answers

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