Podcast
Questions and Answers
The name 'Dracunculus medinensis' literally translates to 'little dragon from Medina.' What does this etymology primarily reflect?
The name 'Dracunculus medinensis' literally translates to 'little dragon from Medina.' What does this etymology primarily reflect?
- A symbolic reference to the fiery pain experienced by sufferers.
- The resemblance of the parasite to a miniature dragon.
- The mythical origins of the disease in ancient dragon lore.
- The historical prevalence of the disease in the city of Medina. (correct)
The 'Caduceus' symbol, associated with physicians, incorporates serpents. What is the proposed connection between these serpents and Dracunculiasis?
The 'Caduceus' symbol, associated with physicians, incorporates serpents. What is the proposed connection between these serpents and Dracunculiasis?
- Serpents represent the venomous nature of the Guinea worm larvae.
- Serpents are a metaphor for the fiery pain caused by the emerging worm.
- The serpents depict the Guinea worm being extracted using a stick, a traditional method. (correct)
- The intertwining serpents symbolize the complex lifecycle of the parasite.
During the Dracunculiasis lifecycle, what is the immediate consequence of a human ingesting copepods infected with larvae?
During the Dracunculiasis lifecycle, what is the immediate consequence of a human ingesting copepods infected with larvae?
- The larvae are immediately released and penetrate the skin.
- The copepods multiply in the stomach, increasing the larval load.
- The copepods are digested, releasing larvae that migrate to the intestines. (correct)
- The copepods attach to the intestinal wall and release larvae gradually.
After mating, the male Guinea worm dies. What is the subsequent primary activity of the female worm in the Dracunculiasis lifecycle?
After mating, the male Guinea worm dies. What is the subsequent primary activity of the female worm in the Dracunculiasis lifecycle?
The painful blister associated with Dracunculiasis bursts when submerged in water. What is the primary biological purpose of this event in the parasite's lifecycle?
The painful blister associated with Dracunculiasis bursts when submerged in water. What is the primary biological purpose of this event in the parasite's lifecycle?
Dracunculiasis transmission exhibits a seasonal pattern in dry regions. When is the risk of infection typically HIGHEST?
Dracunculiasis transmission exhibits a seasonal pattern in dry regions. When is the risk of infection typically HIGHEST?
Which type of water source poses the GREATEST risk of Dracunculiasis transmission in affected communities?
Which type of water source poses the GREATEST risk of Dracunculiasis transmission in affected communities?
What is a key characteristic of water sources that typically MINIMIZES the risk of Dracunculiasis transmission?
What is a key characteristic of water sources that typically MINIMIZES the risk of Dracunculiasis transmission?
What is the primary challenge highlighted regarding Dracunculus medinensis eradication?
What is the primary challenge highlighted regarding Dracunculus medinensis eradication?
How are humans infected with schistosomiasis?
How are humans infected with schistosomiasis?
Where do most Schistosoma species reside in the human body?
Where do most Schistosoma species reside in the human body?
Approximately how many eggs can a female Schistosoma worm lay per day?
Approximately how many eggs can a female Schistosoma worm lay per day?
How do Schistosoma eggs exit the human host?
How do Schistosoma eggs exit the human host?
What is the approximate lifecycle duration of Schistosoma in humans?
What is the approximate lifecycle duration of Schistosoma in humans?
What is the name of the Schistosoma hatchling?
What is the name of the Schistosoma hatchling?
How much time does a miracidium have to find a suitable snail host?
How much time does a miracidium have to find a suitable snail host?
What is the name of the Schistosoma larvae shed by the snail?
What is the name of the Schistosoma larvae shed by the snail?
How do cercaria locate a human host?
How do cercaria locate a human host?
Which of the following combinations of NTDs are most likely to be targeted for integrated control based on the WHO roadmap 2020-2030?
Which of the following combinations of NTDs are most likely to be targeted for integrated control based on the WHO roadmap 2020-2030?
What percentage of people requiring preventative chemotherapy for NTDs need treatment for three or more diseases according to the WHO roadmap?
What percentage of people requiring preventative chemotherapy for NTDs need treatment for three or more diseases according to the WHO roadmap?
Which core strategic intervention addresses the lack of private toilets and improved latrines?
Which core strategic intervention addresses the lack of private toilets and improved latrines?
According to the provided data, approximately how many more people lack access to basic drinking water services compared to those who practice open defecation?
According to the provided data, approximately how many more people lack access to basic drinking water services compared to those who practice open defecation?
If the global population is approximately 8 billion, what percentage of the global population lacks access to basic sanitation facilities, according to the provided data?
If the global population is approximately 8 billion, what percentage of the global population lacks access to basic sanitation facilities, according to the provided data?
Given a diagnostic test with 100% sensitivity and 99% specificity, and a disease incidence of 1%, what is the probability that a positive test result is a true positive?
Given a diagnostic test with 100% sensitivity and 99% specificity, and a disease incidence of 1%, what is the probability that a positive test result is a true positive?
Which of the following is NOT a challenge related to political instability in addressing NTDs?
Which of the following is NOT a challenge related to political instability in addressing NTDs?
How does climate change impact the spread of NTDs?
How does climate change impact the spread of NTDs?
Why is high specificity crucial for diagnostics, especially when disease incidence is low?
Why is high specificity crucial for diagnostics, especially when disease incidence is low?
What role do zoonoses play in the persistence of NTDs?
What role do zoonoses play in the persistence of NTDs?
How can migration and population movement contribute to the resurgence of NTDs?
How can migration and population movement contribute to the resurgence of NTDs?
What contributes to insecticide resistance in combating NTDs?
What contributes to insecticide resistance in combating NTDs?
In the context of a diagnostic test, what does a true positive rate represent?
In the context of a diagnostic test, what does a true positive rate represent?
What is the primary concern if a part of the Guinea worm is not removed from the infected individual?
What is the primary concern if a part of the Guinea worm is not removed from the infected individual?
Aside from protected water sources, what other preventative measure related to food is mentioned in the eradication program's education efforts?
Aside from protected water sources, what other preventative measure related to food is mentioned in the eradication program's education efforts?
What specific type of water filter is mentioned as a tool in the WASH interventions for Guinea worm eradication?
What specific type of water filter is mentioned as a tool in the WASH interventions for Guinea worm eradication?
Beyond providing safe water sources and filters, what other WASH intervention is recommended for at-risk communities?
Beyond providing safe water sources and filters, what other WASH intervention is recommended for at-risk communities?
What is the significance of the year 1980 in the context of Dracunculiasis?
What is the significance of the year 1980 in the context of Dracunculiasis?
According to the provided data, which country reported the highest number of Dracunculiasis cases in 2018?
According to the provided data, which country reported the highest number of Dracunculiasis cases in 2018?
What poses a significant challenge to the complete eradication of Dracunculiasis?
What poses a significant challenge to the complete eradication of Dracunculiasis?
Which medications are suggested to alleviate symptoms associated with Dracunculiasis?
Which medications are suggested to alleviate symptoms associated with Dracunculiasis?
The term 'Neglected' in Neglected Tropical Diseases (NTDs) primarily highlights the:
The term 'Neglected' in Neglected Tropical Diseases (NTDs) primarily highlights the:
The World Health Organization (WHO) officially adopted the term 'Neglected Tropical Diseases' (NTDs) in:
The World Health Organization (WHO) officially adopted the term 'Neglected Tropical Diseases' (NTDs) in:
The primary impetus behind coining the term 'Neglected Tropical Diseases' (NTDs) was to:
The primary impetus behind coining the term 'Neglected Tropical Diseases' (NTDs) was to:
Initially, Neglected Tropical Diseases (NTDs) were characterized by their causation through:
Initially, Neglected Tropical Diseases (NTDs) were characterized by their causation through:
The inclusion of specific diseases under the 'Neglected Tropical Diseases' (NTDs) umbrella was primarily justified by their suitability for:
The inclusion of specific diseases under the 'Neglected Tropical Diseases' (NTDs) umbrella was primarily justified by their suitability for:
According to the information provided, the World Health Organization (WHO) has officially designated approximately how many distinct Neglected Tropical Diseases (NTDs)?
According to the information provided, the World Health Organization (WHO) has officially designated approximately how many distinct Neglected Tropical Diseases (NTDs)?
Among the categories of pathogens causing Neglected Tropical Diseases (NTDs) listed, which pairing is entirely composed of eukaryotic organisms?
Among the categories of pathogens causing Neglected Tropical Diseases (NTDs) listed, which pairing is entirely composed of eukaryotic organisms?
Which of the following Neglected Tropical Diseases (NTDs) from the list provided is NOT caused by a bacterium?
Which of the following Neglected Tropical Diseases (NTDs) from the list provided is NOT caused by a bacterium?
What induces granuloma formation in the chronic phase of schistosomiasis?
What induces granuloma formation in the chronic phase of schistosomiasis?
Which symptom is commonly associated with the acute phase of schistosomiasis?
Which symptom is commonly associated with the acute phase of schistosomiasis?
Which factor primarily contributes to the organ damage in chronic schistosomiasis?
Which factor primarily contributes to the organ damage in chronic schistosomiasis?
What is the duration range of the acute phase of schistosomiasis?
What is the duration range of the acute phase of schistosomiasis?
During the chronic phase, which medical condition occurs due to schistosomiasis?
During the chronic phase, which medical condition occurs due to schistosomiasis?
What are common symptoms of schistosomiasis in endemic areas?
What are common symptoms of schistosomiasis in endemic areas?
What long-term complications may arise from severe bilharzia infections?
What long-term complications may arise from severe bilharzia infections?
How can schistosomiasis affect schooling in children?
How can schistosomiasis affect schooling in children?
What reproductive health issues can result from schistosomiasis in women?
What reproductive health issues can result from schistosomiasis in women?
At what age are children in endemic areas likely to experience their first schistosomiasis infection?
At what age are children in endemic areas likely to experience their first schistosomiasis infection?
Which term describes the swellings caused by schistosomiasis in infected individuals?
Which term describes the swellings caused by schistosomiasis in infected individuals?
Which of the following is NOT a potential health issue caused by schistosomiasis?
Which of the following is NOT a potential health issue caused by schistosomiasis?
What is a primary factor that determines the geographical range of schistosomiasis?
What is a primary factor that determines the geographical range of schistosomiasis?
Which of the following complications can occur later in life due to schistosomiasis?
Which of the following complications can occur later in life due to schistosomiasis?
What was a significant outcome of improved treatments for schistosomiasis by 2016?
What was a significant outcome of improved treatments for schistosomiasis by 2016?
What percentage of schistosomiasis affected individuals are located in Africa?
What percentage of schistosomiasis affected individuals are located in Africa?
Which form is responsible for human infection in schistosomiasis?
Which form is responsible for human infection in schistosomiasis?
How does schistosomiasis rank in terms of parasitic diseases worldwide?
How does schistosomiasis rank in terms of parasitic diseases worldwide?
What does the term 'DALYs' associated with schistosomiasis stand for?
What does the term 'DALYs' associated with schistosomiasis stand for?
In the context of schistosomiasis, what is the primary role of miracidia?
In the context of schistosomiasis, what is the primary role of miracidia?
What was a noted effect of better access to schistosomiasis treatment by 2016?
What was a noted effect of better access to schistosomiasis treatment by 2016?
According to the WHO roadmap 2021-2030, what is the primary objective regarding the number of people requiring interventions against NTDs?
According to the WHO roadmap 2021-2030, what is the primary objective regarding the number of people requiring interventions against NTDs?
Which disease achieved a significant milestone of being eliminated in four countries within the Americas by 2019?
Which disease achieved a significant milestone of being eliminated in four countries within the Americas by 2019?
Which disease saw a substantial reduction in South-East Asia, with annual cases dropping to less than 5,000?
Which disease saw a substantial reduction in South-East Asia, with annual cases dropping to less than 5,000?
For which disease was a 2020 target missed regarding changing discriminatory laws?
For which disease was a 2020 target missed regarding changing discriminatory laws?
Which two NTDs are specifically targeted for eradication by 2030, according to the WHO roadmap?
Which two NTDs are specifically targeted for eradication by 2030, according to the WHO roadmap?
In addition to eradication of two specific NTDs, how many NTDs are targeted for elimination as a public health problem by 2030?
In addition to eradication of two specific NTDs, how many NTDs are targeted for elimination as a public health problem by 2030?
What was the status of Human African trypanosomiasis by 2012?
What was the status of Human African trypanosomiasis by 2012?
What was the 2020 target related to lymphatic filariasis that was missed?
What was the 2020 target related to lymphatic filariasis that was missed?
What quantitative target related to disability-adjusted life years (DALYs) is set for NTDs in the 2030 roadmap?
What quantitative target related to disability-adjusted life years (DALYs) is set for NTDs in the 2030 roadmap?
How many countries are expected to have eliminated at least one NTD by 2030?
How many countries are expected to have eliminated at least one NTD by 2030?
Given a diagnostic test with 100% sensitivity, what would a specificity of 98% indicate about the test's performance on a population where the actual disease prevalence is extremely low?
Given a diagnostic test with 100% sensitivity, what would a specificity of 98% indicate about the test's performance on a population where the actual disease prevalence is extremely low?
How do the challenges of political instability and climate change intersect to exacerbate the difficulty of controlling NTDs?
How do the challenges of political instability and climate change intersect to exacerbate the difficulty of controlling NTDs?
If a diagnostic test for a disease with a 0.1% prevalence has 99% sensitivity and 95% specificity, what can be inferred about the likelihood of a positive test result being a true positive?
If a diagnostic test for a disease with a 0.1% prevalence has 99% sensitivity and 95% specificity, what can be inferred about the likelihood of a positive test result being a true positive?
Why is the combined effect of antimicrobial and insecticide resistance a significant challenge in tackling NTDs?
Why is the combined effect of antimicrobial and insecticide resistance a significant challenge in tackling NTDs?
How does the presence of animal reservoirs (zoonoses) complicate NTD eradication efforts?
How does the presence of animal reservoirs (zoonoses) complicate NTD eradication efforts?
Considering the challenges of NTD control, why is high specificity particularly crucial for diagnostics in low-prevalence settings?
Considering the challenges of NTD control, why is high specificity particularly crucial for diagnostics in low-prevalence settings?
What is the critical implication of the statement, "To be useful the diagnostic must therefore have a HIGHER SPECIFICITY when disease incidence is LOW"?
What is the critical implication of the statement, "To be useful the diagnostic must therefore have a HIGHER SPECIFICITY when disease incidence is LOW"?
How does migration and population movement specifically contribute to the resurgence or introduction of NTDs?
How does migration and population movement specifically contribute to the resurgence or introduction of NTDs?
Flashcards
Neglected Tropical Diseases (NTDs)
Neglected Tropical Diseases (NTDs)
Diseases that primarily affect impoverished populations with limited healthcare access.
Preventive chemotherapy
Preventive chemotherapy
A key strategy in NTD control that involves providing treatment to at-risk populations to prevent disease.
WASH
WASH
Water, Sanitation, and Hygiene; essential services for health and disease prevention.
Impact of inadequate WASH
Impact of inadequate WASH
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Vector control
Vector control
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Test line
Test line
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Sensitivity
Sensitivity
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Specificity
Specificity
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Impact of low disease incidence
Impact of low disease incidence
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Political instability in NTDs
Political instability in NTDs
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Climate change effects on NTDs
Climate change effects on NTDs
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Antimicrobial resistance
Antimicrobial resistance
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Zoonoses
Zoonoses
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Schistosoma spp.
Schistosoma spp.
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Gynecophoral canal
Gynecophoral canal
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En copula
En copula
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Suckers on male worms
Suckers on male worms
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Lifespan of Schistosoma
Lifespan of Schistosoma
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Schistosomiasis
Schistosomiasis
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Definitive host
Definitive host
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Intermediate host
Intermediate host
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Lifecycle duration in humans
Lifecycle duration in humans
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Miracidium
Miracidium
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Cercaria
Cercaria
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Female worm reproduction
Female worm reproduction
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Contaminated water transmission
Contaminated water transmission
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Egg excretion in humans
Egg excretion in humans
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Positive phototropism
Positive phototropism
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Dracunculiasis
Dracunculiasis
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Secondary bacterial infections
Secondary bacterial infections
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Prevention of disease spread
Prevention of disease spread
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Eradication program
Eradication program
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WASH interventions
WASH interventions
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Zoonotic disease
Zoonotic disease
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Safe water sources
Safe water sources
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Copepods
Copepods
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Dracunculus medinensis
Dracunculus medinensis
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Lifecycle of Dracunculiasis
Lifecycle of Dracunculiasis
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Infection process
Infection process
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Blister formation
Blister formation
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Guinea worm transmission
Guinea worm transmission
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Seasonal infection pattern
Seasonal infection pattern
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Caduceus symbol
Caduceus symbol
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Historical treatment
Historical treatment
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Examples of NTDs
Examples of NTDs
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WHO and NTDs
WHO and NTDs
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Infectious agents of NTDs
Infectious agents of NTDs
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Parasitic worm NTDs
Parasitic worm NTDs
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Control and elimination strategies
Control and elimination strategies
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Tropical regions
Tropical regions
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Lobbying for NTDs
Lobbying for NTDs
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Control of NTDs
Control of NTDs
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Dracunculiasis status
Dracunculiasis status
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Leprosy elimination
Leprosy elimination
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Lymphatic filariasis reduction
Lymphatic filariasis reduction
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WHO Roadmap aims
WHO Roadmap aims
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NTDs targeted for eradication
NTDs targeted for eradication
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Urban Leptospirosis
Urban Leptospirosis
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Impact of non-achieved targets
Impact of non-achieved targets
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Trachoma status
Trachoma status
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Rabies elimination efforts
Rabies elimination efforts
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True Positive Rate
True Positive Rate
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True Negative Rate
True Negative Rate
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Diagnostic Sensitivity
Diagnostic Sensitivity
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Diagnostic Specificity
Diagnostic Specificity
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Climate Change and NTDs
Climate Change and NTDs
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Motility of infective forms
Motility of infective forms
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Epidemiology of schistosomiasis
Epidemiology of schistosomiasis
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At-risk population for schistosomiasis
At-risk population for schistosomiasis
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Death toll from schistosomiasis 2000 vs 2016
Death toll from schistosomiasis 2000 vs 2016
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DALYs for schistosomiasis
DALYs for schistosomiasis
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Ranking of schistosomiasis
Ranking of schistosomiasis
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Katayama syndrome
Katayama syndrome
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Chronic phase symptoms
Chronic phase symptoms
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Granuloma formation
Granuloma formation
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Egg deposition
Egg deposition
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Fibrosis and lesions
Fibrosis and lesions
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Kidney dysfunction symptoms
Kidney dysfunction symptoms
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Chronic effects of bilharzia
Chronic effects of bilharzia
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Female genital schistosomiasis (FGS)
Female genital schistosomiasis (FGS)
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Hepatosplenomegaly
Hepatosplenomegaly
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Under-nutrition consequences
Under-nutrition consequences
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Children's schistosomiasis infection
Children's schistosomiasis infection
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Symptoms of schistosomiasis
Symptoms of schistosomiasis
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Schistosomiasis cognitive impact
Schistosomiasis cognitive impact
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Study Notes
Neglected Tropical Diseases (NTDs)
- NTDs are historically not effectively addressed by drug companies due to economic considerations
- They occur in developing regions of Africa, Asia, and South and Central America
- WHO and partners brought together various disease initiatives under the NTD "brand" in 2007
- Inclusion criteria for NTDs focused on transmission characteristics and treatment opportunities
- There are 20 NTDs identified by the WHO
Examples of NTDs
- Bacteria: Buruli ulcer ( Mycobacterium ulcerans), Leprosy ( Mycobacterium leprae), Trachoma ( Chlamydia trachomatis), Yaws ( Treponema pallidum)
- Viruses: Dengue and chikungunya (virus), Rabies (rabies virus)
- Others: Mycetoma, chromoblastomycosis, other deep mycoses (fungus), Scabies and other ectoparasitoses (mites), Snakebite envenoming (snake bites), Chagas disease ( Trypanosome cruzi), Human African trypanosomiasis ( Trypanosoma brucei), Leishmaniasis ( Leishmania spp),
- Parasitic worms: Dracunculiasis (guinea worm), Echinococcosis (tapeworm), Foodborne trematodiases (platyhelminth worm), Elephantitis/Lymphatic filariasis (nematode worms), River blindness/Onchocerciasis ( Onchocerca volvulus), Schistosomiasis ( schistosoma worm), Soil-transmitted helminthiases (nematode worm), Taeniasis and cysticercosis (tapeworm).
NTD Spread
- Most NTDs are spread by a vector, such as mosquitos, flies, mites, or snails, or through contaminated food
- Some are transmitted from person to person (e.g., Leprosy, Trachoma, Yaws)
NTD Measurement
- Health impact measured by mortality, morbidity, disability-adjusted life years (DALYs)
- Years of life lost (YLLs) due to premature mortality, Years lived with disability (YLDs)
- Number of people living in endemic areas at risk of infection
NTD prevalence (2015)
- A large proportion of people living below the World Bank poverty line of US$1.90 per day globally are infected with at least one NTD disease.
- This is at least 10% of the global population.
NTD Funding
- Funding for NTDs has been relatively static at approximately $300 million annually for the past decade.
- Pharmaceutical companies donate an average of nearly three billion tablets of medicines annually that are worth hundreds of millions of dollars,
- WHO estimated that NTD interventions could cost up to $750 million in 2020
Financial Advantages of NTD Intervention
- Spending on NTD intervention is a costeffective way to improve the health and well-being of populations.
- The financial benefits extend to citizens financially.
- Increasing productivity for society
- Each $1 invested in preventive chemotherapy for NTDs may result in up to $25 of benefits
- Reduced medical expenses paid by the patient, reduced lost productivity and a 30% annualised rate of return over 12 years.
- Spending $1 on water and sanitation may produce a return greater than $5
2012–2020 Roadmap
- The WHO 2012-2020 NTD roadmap was a series of goals and strategies aimed at combating NTDs
- Significant progress was made, including reducing the number of people requiring intervention, elimination in 42 areas, and increased preventative coverage.
- Fewer people require treatment than in 2010
- Some NTDs had been eliminated in some countries
NTD 2020-2030 Roadmap
- The aim of the 2021-2030 roadmap is to free 1 billion individuals from needing NTD interventions and avoid millions more from catastrophic out-of-pocket expenses.
- Goals include 90% reduction reduction in NTD-related individuals needing intervention, 75% reduction in NTD morbidity, 100 countries having eliminated at least one NTD, and eradication of 2 NTD globally.
WASH and NTDs
- Improved sanitation practices are needed to reduce the transmission of several NTDs,
- Prevention of open defecation, access to potable water, safe sewage treatment, and appropriate water use are all vital elements in managing NTDs.
Schistosomiasis (Bilharzia)
- Caused by parasitic worms transmitted to humans through contact with infected water.
- Symptoms include initial rash, fatigue, abdominal pain, kidney dysfunction, blood in urine and stools
- Lifecycle includes mammals, snails, miracidium and cercariae
- Affected areas include parts of Africa, Asia, and some of South America.
- Approximately 779 million people worldwide are at risk, with 90% of cases in Africa.
- Efforts focus on education, safe water access and snail control.
- NTDs occur worldwide but are more prevalent in less developed countries
Dracunculiasis/ Guinea Worm Disease
- Caused by a nematode worm that enters the body through drinking contaminated water.
- Progress has been made towards its eradication through WASH (water sanitation and hygiene) initiatives
- Eradication program began in the 1980s, focusing on educating populations and distributing water filters.
- It's one of two NTDs the WHO is aiming to eliminate.
Diagnostics for NTDs
- Many NTD diagnostics are older technologies requiring little training and limited sensitivity/specificity
- There is a need for efficient, accurate and inexpensive tests that integrate well with existing healthcare settings.
- 5% of research and development investment for NTDs compared to 39% devoted to medicines and vaccines.
NTD Challenges
- Political instability, diversion of funding, infrastructural issues, or risks to healthcare personnel.
- Migrations, displaced populations living in temporary accommodation, inadequate sanitation, limited water access and climate change issues affect the spread and management of NTDs significantly.
- Antimicrobial and insecticide resistance.
- Zoonotic potential, meaning animals can be intermediate hosts, requiring further interventions.
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