Dracunculiasis Lifecycle and Etymology Quiz

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Questions and Answers

The name 'Dracunculus medinensis' literally translates to 'little dragon from Medina.' What does this etymology primarily reflect?

  • A symbolic reference to the fiery pain experienced by sufferers.
  • The resemblance of the parasite to a miniature dragon.
  • The mythical origins of the disease in ancient dragon lore.
  • The historical prevalence of the disease in the city of Medina. (correct)

The 'Caduceus' symbol, associated with physicians, incorporates serpents. What is the proposed connection between these serpents and Dracunculiasis?

  • Serpents represent the venomous nature of the Guinea worm larvae.
  • Serpents are a metaphor for the fiery pain caused by the emerging worm.
  • The serpents depict the Guinea worm being extracted using a stick, a traditional method. (correct)
  • The intertwining serpents symbolize the complex lifecycle of the parasite.

During the Dracunculiasis lifecycle, what is the immediate consequence of a human ingesting copepods infected with larvae?

  • The larvae are immediately released and penetrate the skin.
  • The copepods multiply in the stomach, increasing the larval load.
  • The copepods are digested, releasing larvae that migrate to the intestines. (correct)
  • The copepods attach to the intestinal wall and release larvae gradually.

After mating, the male Guinea worm dies. What is the subsequent primary activity of the female worm in the Dracunculiasis lifecycle?

<p>She slowly migrates towards the body surface, typically in the lower limbs. (C)</p> Signup and view all the answers

The painful blister associated with Dracunculiasis bursts when submerged in water. What is the primary biological purpose of this event in the parasite's lifecycle?

<p>To enable the female worm to release larvae into the water, infecting copepods. (B)</p> Signup and view all the answers

Dracunculiasis transmission exhibits a seasonal pattern in dry regions. When is the risk of infection typically HIGHEST?

<p>At the onset of the rainy season, when stagnant surface water accumulates. (A)</p> Signup and view all the answers

Which type of water source poses the GREATEST risk of Dracunculiasis transmission in affected communities?

<p>Stagnant ponds and pools in drying riverbeds. (C)</p> Signup and view all the answers

What is a key characteristic of water sources that typically MINIMIZES the risk of Dracunculiasis transmission?

<p>Flowing nature, which reduces copepod concentration. (B)</p> Signup and view all the answers

What is the primary challenge highlighted regarding Dracunculus medinensis eradication?

<p>Difficulties arise in the final stages of eradication, often in non-human mammal populations. (D)</p> Signup and view all the answers

How are humans infected with schistosomiasis?

<p>Contact with contaminated water. (B)</p> Signup and view all the answers

Where do most Schistosoma species reside in the human body?

<p>Mesenteric vein system near the gut. (C)</p> Signup and view all the answers

Approximately how many eggs can a female Schistosoma worm lay per day?

<p>200-3,000 (B)</p> Signup and view all the answers

How do Schistosoma eggs exit the human host?

<p>In faeces or urine. (A)</p> Signup and view all the answers

What is the approximate lifecycle duration of Schistosoma in humans?

<p>6-7 weeks (A)</p> Signup and view all the answers

What is the name of the Schistosoma hatchling?

<p>Miracidium (B)</p> Signup and view all the answers

How much time does a miracidium have to find a suitable snail host?

<p>A few hours. (C)</p> Signup and view all the answers

What is the name of the Schistosoma larvae shed by the snail?

<p>Cercaria (C)</p> Signup and view all the answers

How do cercaria locate a human host?

<p>Positive phototropism and chemoattractants. (C)</p> Signup and view all the answers

Which of the following combinations of NTDs are most likely to be targeted for integrated control based on the WHO roadmap 2020-2030?

<p>Foodborne trematodiases and Taeniasis and cysticercosis and scabies (D)</p> Signup and view all the answers

What percentage of people requiring preventative chemotherapy for NTDs need treatment for three or more diseases according to the WHO roadmap?

<p>43% (B)</p> Signup and view all the answers

Which core strategic intervention addresses the lack of private toilets and improved latrines?

<p>WASH (C)</p> Signup and view all the answers

According to the provided data, approximately how many more people lack access to basic drinking water services compared to those who practice open defecation?

<p>122 Million (A)</p> Signup and view all the answers

If the global population is approximately 8 billion, what percentage of the global population lacks access to basic sanitation facilities, according to the provided data?

<p>25% (B)</p> Signup and view all the answers

Given a diagnostic test with 100% sensitivity and 99% specificity, and a disease incidence of 1%, what is the probability that a positive test result is a true positive?

<p>50% (A)</p> Signup and view all the answers

Which of the following is NOT a challenge related to political instability in addressing NTDs?

<p>Antimicrobial resistance (C)</p> Signup and view all the answers

How does climate change impact the spread of NTDs?

<p>By altering the epidemiology of vector-borne diseases (C)</p> Signup and view all the answers

Why is high specificity crucial for diagnostics, especially when disease incidence is low?

<p>To minimize false positives and increase the reliability of positive results. (A)</p> Signup and view all the answers

What role do zoonoses play in the persistence of NTDs?

<p>They provide an animal reservoir for the disease, making eradication more difficult. (D)</p> Signup and view all the answers

How can migration and population movement contribute to the resurgence of NTDs?

<p>By creating environments with poor sanitation and limited healthcare access, favoring disease transmission. (B)</p> Signup and view all the answers

What contributes to insecticide resistance in combating NTDs?

<p>Widespread use of insecticides for vector control promoting resistance development (C)</p> Signup and view all the answers

In the context of a diagnostic test, what does a true positive rate represent?

<p>The proportion of people with the disease who test positive. (A)</p> Signup and view all the answers

What is the primary concern if a part of the Guinea worm is not removed from the infected individual?

<p>Secondary bacterial infections and potential complications. (C)</p> Signup and view all the answers

Aside from protected water sources, what other preventative measure related to food is mentioned in the eradication program's education efforts?

<p>Properly cook fish and other aquatic animals before eating them. (A)</p> Signup and view all the answers

What specific type of water filter is mentioned as a tool in the WASH interventions for Guinea worm eradication?

<p>Guinea worm cloth filter (C)</p> Signup and view all the answers

Beyond providing safe water sources and filters, what other WASH intervention is recommended for at-risk communities?

<p>Repairing broken safe water sources like hand-pumps. (C)</p> Signup and view all the answers

What is the significance of the year 1980 in the context of Dracunculiasis?

<p>The year the Guinea worm eradication program began. (B)</p> Signup and view all the answers

According to the provided data, which country reported the highest number of Dracunculiasis cases in 2018?

<p>Chad (D)</p> Signup and view all the answers

What poses a significant challenge to the complete eradication of Dracunculiasis?

<p>The zoonotic nature of the disease. (C)</p> Signup and view all the answers

Which medications are suggested to alleviate symptoms associated with Dracunculiasis?

<p>Anti-inflammatory medication and antibiotic ointment. (C)</p> Signup and view all the answers

The term 'Neglected' in Neglected Tropical Diseases (NTDs) primarily highlights the:

<p>historical under-prioritization by pharmaceutical companies due to limited commercial viability. (D)</p> Signup and view all the answers

The World Health Organization (WHO) officially adopted the term 'Neglected Tropical Diseases' (NTDs) in:

<p>2007, to consolidate various disease-specific initiatives. (D)</p> Signup and view all the answers

The primary impetus behind coining the term 'Neglected Tropical Diseases' (NTDs) was to:

<p>galvanize political attention and resource mobilization for a set of historically marginalized diseases. (B)</p> Signup and view all the answers

Initially, Neglected Tropical Diseases (NTDs) were characterized by their causation through:

<p>infectious agents including bacteria, viruses, and parasites. (D)</p> Signup and view all the answers

The inclusion of specific diseases under the 'Neglected Tropical Diseases' (NTDs) umbrella was primarily justified by their suitability for:

<p>effective control and potential elimination based on transmission dynamics and treatment availability. (B)</p> Signup and view all the answers

According to the information provided, the World Health Organization (WHO) has officially designated approximately how many distinct Neglected Tropical Diseases (NTDs)?

<p>20 (A)</p> Signup and view all the answers

Among the categories of pathogens causing Neglected Tropical Diseases (NTDs) listed, which pairing is entirely composed of eukaryotic organisms?

<p>Protozoa and Helminths (parasitic worms - implied) (A)</p> Signup and view all the answers

Which of the following Neglected Tropical Diseases (NTDs) from the list provided is NOT caused by a bacterium?

<p>Chagas disease (C)</p> Signup and view all the answers

What induces granuloma formation in the chronic phase of schistosomiasis?

<p>Egg secretion (A)</p> Signup and view all the answers

Which symptom is commonly associated with the acute phase of schistosomiasis?

<p>Katayama syndrome (C)</p> Signup and view all the answers

Which factor primarily contributes to the organ damage in chronic schistosomiasis?

<p>Host's immune response to eggs (D)</p> Signup and view all the answers

What is the duration range of the acute phase of schistosomiasis?

<p>14-84 days (D)</p> Signup and view all the answers

During the chronic phase, which medical condition occurs due to schistosomiasis?

<p>Liver cirrhosis (A)</p> Signup and view all the answers

What are common symptoms of schistosomiasis in endemic areas?

<p>Blood in stools and diarrhea (A), Hepatosplenomegaly and chronic ill health (D)</p> Signup and view all the answers

What long-term complications may arise from severe bilharzia infections?

<p>Bladder cancer and cognitive impairment (D)</p> Signup and view all the answers

How can schistosomiasis affect schooling in children?

<p>Causes fatigue and impacts learning ability (D)</p> Signup and view all the answers

What reproductive health issues can result from schistosomiasis in women?

<p>Female genital schistosomiasis and increased HIV risk (D)</p> Signup and view all the answers

At what age are children in endemic areas likely to experience their first schistosomiasis infection?

<p>By 2 years (D)</p> Signup and view all the answers

Which term describes the swellings caused by schistosomiasis in infected individuals?

<p>Hepatosplenomegaly (B)</p> Signup and view all the answers

Which of the following is NOT a potential health issue caused by schistosomiasis?

<p>Improved respiratory function (D)</p> Signup and view all the answers

What is a primary factor that determines the geographical range of schistosomiasis?

<p>Presence of specific snail species (D)</p> Signup and view all the answers

Which of the following complications can occur later in life due to schistosomiasis?

<p>Bladder cancer (C)</p> Signup and view all the answers

What was a significant outcome of improved treatments for schistosomiasis by 2016?

<p>Reduction in deaths and DALY burden (D)</p> Signup and view all the answers

What percentage of schistosomiasis affected individuals are located in Africa?

<p>90% (B)</p> Signup and view all the answers

Which form is responsible for human infection in schistosomiasis?

<p>Cercariae (B)</p> Signup and view all the answers

How does schistosomiasis rank in terms of parasitic diseases worldwide?

<p>Second (B)</p> Signup and view all the answers

What does the term 'DALYs' associated with schistosomiasis stand for?

<p>Disability Adjusted Life Years (D)</p> Signup and view all the answers

In the context of schistosomiasis, what is the primary role of miracidia?

<p>Finding a snail host (B)</p> Signup and view all the answers

What was a noted effect of better access to schistosomiasis treatment by 2016?

<p>Decrease in schistosomiasis-related mortality (B)</p> Signup and view all the answers

According to the WHO roadmap 2021-2030, what is the primary objective regarding the number of people requiring interventions against NTDs?

<p>A 90% reduction (D)</p> Signup and view all the answers

Which disease achieved a significant milestone of being eliminated in four countries within the Americas by 2019?

<p>Onchocerciasis (D)</p> Signup and view all the answers

Which disease saw a substantial reduction in South-East Asia, with annual cases dropping to less than 5,000?

<p>Leishmaniasis (D)</p> Signup and view all the answers

For which disease was a 2020 target missed regarding changing discriminatory laws?

<p>Leprosy (C)</p> Signup and view all the answers

Which two NTDs are specifically targeted for eradication by 2030, according to the WHO roadmap?

<p>Dracunculiasis and Yaws (C)</p> Signup and view all the answers

In addition to eradication of two specific NTDs, how many NTDs are targeted for elimination as a public health problem by 2030?

<p>Eight (D)</p> Signup and view all the answers

What was the status of Human African trypanosomiasis by 2012?

<p>Eliminated as a public health problem (A)</p> Signup and view all the answers

What was the 2020 target related to lymphatic filariasis that was missed?

<p>Global elimination as a public health problem (A)</p> Signup and view all the answers

What quantitative target related to disability-adjusted life years (DALYs) is set for NTDs in the 2030 roadmap?

<p>75% reduction (A)</p> Signup and view all the answers

How many countries are expected to have eliminated at least one NTD by 2030?

<p>100 (B)</p> Signup and view all the answers

Given a diagnostic test with 100% sensitivity, what would a specificity of 98% indicate about the test's performance on a population where the actual disease prevalence is extremely low?

<p>A substantial portion of individuals without the disease will receive a false positive result. (C)</p> Signup and view all the answers

How do the challenges of political instability and climate change intersect to exacerbate the difficulty of controlling NTDs?

<p>Political instability hinders access to healthcare and resources, while climate change alters disease epidemiology and spreads vector-borne NTDs. (C)</p> Signup and view all the answers

If a diagnostic test for a disease with a 0.1% prevalence has 99% sensitivity and 95% specificity, what can be inferred about the likelihood of a positive test result being a true positive?

<p>Relatively low, as false positives are expected to be substantially more common than true positives in the population. (D)</p> Signup and view all the answers

Why is the combined effect of antimicrobial and insecticide resistance a significant challenge in tackling NTDs?

<p>It reduces the effectiveness of readily available control measures, necessitating the development of new treatments. (D)</p> Signup and view all the answers

How does the presence of animal reservoirs (zoonoses) complicate NTD eradication efforts?

<p>It makes eradication more challenging, as NTDs can persist in animal populations and re-infect humans. (C)</p> Signup and view all the answers

Considering the challenges of NTD control, why is high specificity particularly crucial for diagnostics in low-prevalence settings?

<p>High specificity limits the number of false positives, a critical factor when true positives are rare making false positives proportionally more common. (D)</p> Signup and view all the answers

What is the critical implication of the statement, "To be useful the diagnostic must therefore have a HIGHER SPECIFICITY when disease incidence is LOW"?

<p>As disease incidence falls, there are fewer true positives, and a higher specificity is prioritized to reduce false positives, which disproportionately skew positive results. (C)</p> Signup and view all the answers

How does migration and population movement specifically contribute to the resurgence or introduction of NTDs?

<p>Movement and displacement can cause introduction or reintroduction, especially in settings with poor sanitation, limited healthcare access, and temporary housing. (B)</p> Signup and view all the answers

Flashcards

Neglected Tropical Diseases (NTDs)

Diseases that primarily affect impoverished populations with limited healthcare access.

Preventive chemotherapy

A key strategy in NTD control that involves providing treatment to at-risk populations to prevent disease.

WASH

Water, Sanitation, and Hygiene; essential services for health and disease prevention.

Impact of inadequate WASH

Over 1.5 million deaths annually due to preventable diarrheal illnesses caused by poor water and sanitation.

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Vector control

Strategies aimed at combating disease-carrying organisms like mosquitoes.

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Test line

A line in diagnostic tests indicating the presence of an antigen and labelled antibodies.

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Sensitivity

True Positive Rate; proportion of true positives that test positive.

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Specificity

True Negative Rate; proportion of true negatives that test negative.

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Impact of low disease incidence

Low disease incidence can reduce the probability of true positives despite high sensitivity and specificity.

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Political instability in NTDs

Political issues can disrupt funding and governance for NTD interventions.

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Climate change effects on NTDs

Alters the spread of vector-borne diseases such as dengue and chikungunya.

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Antimicrobial resistance

The ability of microbes to resist the effects of drugs, complicating disease control.

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Zoonoses

Diseases that can be transmitted from animals to humans, often from animal reservoirs.

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Schistosoma spp.

A genus of parasitic worms known to cause schistosomiasis in humans.

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Gynecophoral canal

A groove in the male Schistosoma worm where the female resides during mating.

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En copula

Refers to the paired state of male and female Schistosoma worms during migration.

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Suckers on male worms

Structures that help male Schistosoma attach to blood vessels inside the host.

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Lifespan of Schistosoma

Schistosoma worms can live for several years within their host.

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Schistosomiasis

A disease caused by parasitic helminth worms (blood flukes).

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Definitive host

The organism where the parasite reaches maturity and reproduces, like humans.

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Intermediate host

Organisms (like snails) that host the larval stage of the parasite.

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Lifecycle duration in humans

The lifecycle of schistosomiasis in humans lasts around 6 to 7 weeks.

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Miracidium

The hatchling stage of schistosomiasis that must find a snail host quickly.

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Cercaria

The larval stage shed by snails that swim and penetrate skin to infect hosts.

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Female worm reproduction

Female schistosomes can lay between 200-3,000 eggs per day in the blood.

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Contaminated water transmission

Humans become infected through contact with water contaminated with schistosome eggs.

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Egg excretion in humans

Humans excrete schistosomiasis eggs in feces or urine, depending on species.

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Positive phototropism

Behavior of cercaria larvae where they swim towards light sources to find hosts.

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Dracunculiasis

A parasitic infection caused by the Guinea worm, leading to painful lesions.

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Secondary bacterial infections

Infections that occur due to the presence of another infection, like the Guinea worm.

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Prevention of disease spread

Measures taken to stop the contamination of water sources by infected individuals.

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Eradication program

Initiative started in 1980 aimed at eliminating Guinea worm disease.

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WASH interventions

Water, Sanitation, and Hygiene programs aimed at improving water safety.

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Zoonotic disease

A disease that can be transmitted from animals to humans, like dracunculiasis.

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Safe water sources

Water supplies that are free from contaminants, crucial in prevention.

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Copepods

Tiny crustaceans that can carry Guinea worm larvae, posing a risk to drinking water.

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Dracunculus medinensis

A parasitic worm known as Guinea worm, historically linked to biblical references.

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Lifecycle of Dracunculiasis

Infection occurs when water containing copepods is consumed, leading to worm maturation in the body.

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Infection process

Ingested copepods die in the stomach, releasing larvae that penetrate the intestinal wall.

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Blister formation

A blister forms on the skin as the female worm migrates to the surface, causing pain.

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Guinea worm transmission

Primarily affects impoverished communities lacking clean drinking water, especially stagnant sources.

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Seasonal infection pattern

In dry regions, infections peak during the rainy season due to stagnant water availability.

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Caduceus symbol

The symbol of a physician, often confused with the staff of Hermes, symbolizes healing and medicine.

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Historical treatment

Persian physicians in the 9th century used manual techniques to remove Dracunculus medinensis from patients.

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Examples of NTDs

NTDs include diseases like Buruli ulcer, leprosy, and Chagas disease.

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WHO and NTDs

WHO designated 20 NTDs to unify efforts and increase attention and funding for their control.

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Infectious agents of NTDs

Many NTDs are caused by infectious agents such as bacteria, viruses, and parasites.

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Parasitic worm NTDs

Examples of NTDs caused by parasitic worms include schistosomiasis and lymphatic filariasis.

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Control and elimination strategies

NTDs can be controlled through treatments, preventive measures, and vector control efforts.

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Tropical regions

NTDs primarily occur in tropical and subtropical areas of Africa, Asia, and Latin America.

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Lobbying for NTDs

The term 'Neglected Tropical Diseases' was coined to raise awareness and support for affected populations.

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Control of NTDs

The process of reducing disease incidence and maintaining low levels in populations.

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Dracunculiasis status

Nearly eradicated with only 54 cases reported in 2019.

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Leprosy elimination

Global decline in leprosy cases; most countries achieved elimination criteria.

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Lymphatic filariasis reduction

43% reduction in the population needing treatment, with 17 countries achieving elimination.

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WHO Roadmap aims

Targets for 2030 include a 90% reduction in people needing NTD interventions.

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NTDs targeted for eradication

Dracunculiasis and Yaws are set for eradication efforts by 2030.

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Urban Leptospirosis

Status of Leptospirosis in urban areas indicates ongoing public health challenges.

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Impact of non-achieved targets

Many NTD targets for 2020 remain unmet, highlighting ongoing health gaps.

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Trachoma status

Elimination as a public health problem achieved in 10 countries.

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Rabies elimination efforts

Aim to eliminate dog-mediated rabies in several regions, including Mexico.

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True Positive Rate

Proportion of true cases that test positive; also called sensitivity.

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True Negative Rate

Proportion of true cases that test negative; also called specificity.

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Diagnostic Sensitivity

The ability of a test to correctly identify those with the disease.

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Diagnostic Specificity

The ability of a test to correctly identify those without the disease.

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Climate Change and NTDs

Changes in climate can alter the spread of vector-borne diseases.

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Motility of infective forms

Infective forms are highly active and can move rapidly, such as Miracidium using cilia.

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Epidemiology of schistosomiasis

Schistosomiasis is found in 51 countries across Asia, Africa, and parts of South America, affecting 240 million people.

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At-risk population for schistosomiasis

Approximately 779 million people are at risk of schistosomiasis, predominantly in Africa.

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Death toll from schistosomiasis 2000 vs 2016

Schistosomiasis caused 55,000 deaths in 2000 and 24,000 in 2016, due to better treatment availability.

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DALYs for schistosomiasis

In 2000, schistosomiasis caused 4.3 million DALYs; this dropped to 2.5 million in 2016.

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Ranking of schistosomiasis

Schistosomiasis ranks second after malaria for parasitic diseases in terms of prevalence.

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Katayama syndrome

An acute phase of schistosomiasis with symptoms like fever and cough.

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Chronic phase symptoms

Weakness, fatigue, and abdominal pain caused by immune response to schistosome eggs.

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Granuloma formation

Inflammatory response around schistosome eggs leading to tissue damage.

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Egg deposition

Process where schistosome eggs are laid, contributing to immune response.

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Fibrosis and lesions

Scarring and damage in organs due to trapped schistosome eggs and inflammation.

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Kidney dysfunction symptoms

Signs include blood in urine and burning during urination.

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Chronic effects of bilharzia

Long-term impact includes chronic health issues like bladder cancer.

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Female genital schistosomiasis (FGS)

Infection that can complicate pregnancy and increase HIV risk.

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Hepatosplenomegaly

Swelling of the liver and spleen often seen in severe infections.

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Under-nutrition consequences

Linkage to cognitive impairment, growth stunting, and chronic illness.

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Children's schistosomiasis infection

In endemic areas, children commonly become infected by age 2.

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Symptoms of schistosomiasis

Symptoms may include irregular bowel movements and blood in stools.

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Schistosomiasis cognitive impact

Infections are associated with cognitive impairment and lost schooling.

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Study Notes

Neglected Tropical Diseases (NTDs)

  • NTDs are historically not effectively addressed by drug companies due to economic considerations
  • They occur in developing regions of Africa, Asia, and South and Central America
  • WHO and partners brought together various disease initiatives under the NTD "brand" in 2007
  • Inclusion criteria for NTDs focused on transmission characteristics and treatment opportunities
  • There are 20 NTDs identified by the WHO

Examples of NTDs

  • Bacteria: Buruli ulcer ( Mycobacterium ulcerans), Leprosy ( Mycobacterium leprae), Trachoma ( Chlamydia trachomatis), Yaws ( Treponema pallidum)
  • Viruses: Dengue and chikungunya (virus), Rabies (rabies virus)
  • Others: Mycetoma, chromoblastomycosis, other deep mycoses (fungus), Scabies and other ectoparasitoses (mites), Snakebite envenoming (snake bites), Chagas disease ( Trypanosome cruzi), Human African trypanosomiasis ( Trypanosoma brucei), Leishmaniasis ( Leishmania spp),
  • Parasitic worms: Dracunculiasis (guinea worm), Echinococcosis (tapeworm), Foodborne trematodiases (platyhelminth worm), Elephantitis/Lymphatic filariasis (nematode worms), River blindness/Onchocerciasis ( Onchocerca volvulus), Schistosomiasis ( schistosoma worm), Soil-transmitted helminthiases (nematode worm), Taeniasis and cysticercosis (tapeworm).

NTD Spread

  • Most NTDs are spread by a vector, such as mosquitos, flies, mites, or snails, or through contaminated food
  • Some are transmitted from person to person (e.g., Leprosy, Trachoma, Yaws)

NTD Measurement

  • Health impact measured by mortality, morbidity, disability-adjusted life years (DALYs)
  • Years of life lost (YLLs) due to premature mortality, Years lived with disability (YLDs)
  • Number of people living in endemic areas at risk of infection

NTD prevalence (2015)

  • A large proportion of people living below the World Bank poverty line of US$1.90 per day globally are infected with at least one NTD disease.
  • This is at least 10% of the global population.

NTD Funding

  • Funding for NTDs has been relatively static at approximately $300 million annually for the past decade.
  • Pharmaceutical companies donate an average of nearly three billion tablets of medicines annually that are worth hundreds of millions of dollars,
  • WHO estimated that NTD interventions could cost up to $750 million in 2020

Financial Advantages of NTD Intervention

  • Spending on NTD intervention is a costeffective way to improve the health and well-being of populations.
  • The financial benefits extend to citizens financially.
  • Increasing productivity for society
  • Each $1 invested in preventive chemotherapy for NTDs may result in up to $25 of benefits
  • Reduced medical expenses paid by the patient, reduced lost productivity and a 30% annualised rate of return over 12 years.
  • Spending $1 on water and sanitation may produce a return greater than $5

2012–2020 Roadmap

  • The WHO 2012-2020 NTD roadmap was a series of goals and strategies aimed at combating NTDs
  • Significant progress was made, including reducing the number of people requiring intervention, elimination in 42 areas, and increased preventative coverage.
  • Fewer people require treatment than in 2010
  • Some NTDs had been eliminated in some countries

NTD 2020-2030 Roadmap

  • The aim of the 2021-2030 roadmap is to free 1 billion individuals from needing NTD interventions and avoid millions more from catastrophic out-of-pocket expenses.
  • Goals include 90% reduction reduction in NTD-related individuals needing intervention, 75% reduction in NTD morbidity, 100 countries having eliminated at least one NTD, and eradication of 2 NTD globally.

WASH and NTDs

  • Improved sanitation practices are needed to reduce the transmission of several NTDs,
  • Prevention of open defecation, access to potable water, safe sewage treatment, and appropriate water use are all vital elements in managing NTDs.

Schistosomiasis (Bilharzia)

  • Caused by parasitic worms transmitted to humans through contact with infected water.
  • Symptoms include initial rash, fatigue, abdominal pain, kidney dysfunction, blood in urine and stools
  • Lifecycle includes mammals, snails, miracidium and cercariae
  • Affected areas include parts of Africa, Asia, and some of South America.
  • Approximately 779 million people worldwide are at risk, with 90% of cases in Africa.
  • Efforts focus on education, safe water access and snail control.
  • NTDs occur worldwide but are more prevalent in less developed countries

Dracunculiasis/ Guinea Worm Disease

  • Caused by a nematode worm that enters the body through drinking contaminated water.
  • Progress has been made towards its eradication through WASH (water sanitation and hygiene) initiatives
  • Eradication program began in the 1980s, focusing on educating populations and distributing water filters.
  • It's one of two NTDs the WHO is aiming to eliminate.

Diagnostics for NTDs

  • Many NTD diagnostics are older technologies requiring little training and limited sensitivity/specificity
  • There is a need for efficient, accurate and inexpensive tests that integrate well with existing healthcare settings.
  • 5% of research and development investment for NTDs compared to 39% devoted to medicines and vaccines.

NTD Challenges

  • Political instability, diversion of funding, infrastructural issues, or risks to healthcare personnel.
  • Migrations, displaced populations living in temporary accommodation, inadequate sanitation, limited water access and climate change issues affect the spread and management of NTDs significantly.
  • Antimicrobial and insecticide resistance.
  • Zoonotic potential, meaning animals can be intermediate hosts, requiring further interventions.

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