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Dose-Response Curve

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Questions and Answers

Which of the following statements about the dose-response curve for the analgesic effect of morphine is true?

The dose-response curve for the analgesic effect of morphine is lower than the curve for its depressive effect on respiration. (correct)
The dose-response curve for the analgesic effect of morphine cannot be determined from the information given.
The dose-response curve for the analgesic effect of morphine is higher than the curve for its depressive effect on respiration.
The dose-response curve for the analgesic effect of morphine is the same as the curve for its depressive effect on respiration.

What does a drug's margin of safety indicate?

The measure of a drug's therapeutic index.
The difference between the dose-response curve for a drug's analgesic effects and that for its depressive effects on respiration.
The difference between the dose-response curve for a drug's therapeutic effects and that for its adverse side effects. (correct)
The ratio of the toxic dose to the effective dose of a drug.

What is the therapeutic index of a drug?

The measure of a drug's margin of safety.
The difference between the dose that produces the desired effects in 50 percent of the animals and the dose that produces toxic effects in 50 percent of the animals.
The ratio of the toxic dose to the effective dose of a drug. (correct)
The difference between the dose-response curve for a drug's analgesic effects and that for its depressive effects on respiration.

Which of the following is NOT a reason why drugs vary in their effectiveness?

Different therapeutic indexes (D) Signup and view all the answers

What is the definition of therapeutic index?

The ratio between the dose that produces the desired effect and the dose that produces toxic effects (D) Signup and view all the answers

Why does a given dose of morphine produce more pain reduction than the same dose of aspirin?

Morphine suppresses the activity of neurons involved in pain perception, whereas aspirin reduces the production of a chemical involved in transmitting pain information (B) Signup and view all the answers

What is the relationship between a drug's affinity and its effectiveness?

A drug with high affinity produces effects at a relatively low concentration, whereas a drug with low affinity must be administered in higher doses (D) Signup and view all the answers