Dose-Response Curve
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Questions and Answers

Which of the following statements about the dose-response curve for the analgesic effect of morphine is true?

  • The dose-response curve for the analgesic effect of morphine is lower than the curve for its depressive effect on respiration. (correct)
  • The dose-response curve for the analgesic effect of morphine cannot be determined from the information given.
  • The dose-response curve for the analgesic effect of morphine is higher than the curve for its depressive effect on respiration.
  • The dose-response curve for the analgesic effect of morphine is the same as the curve for its depressive effect on respiration.

    • What does a drug's margin of safety indicate?

  • The measure of a drug's therapeutic index.
  • The difference between the dose-response curve for a drug's analgesic effects and that for its depressive effects on respiration.
  • The difference between the dose-response curve for a drug's therapeutic effects and that for its adverse side effects. (correct)
  • The ratio of the toxic dose to the effective dose of a drug.

    • What is the therapeutic index of a drug?

  • The measure of a drug's margin of safety.
  • The difference between the dose that produces the desired effects in 50 percent of the animals and the dose that produces toxic effects in 50 percent of the animals.
  • The ratio of the toxic dose to the effective dose of a drug. (correct)
  • The difference between the dose-response curve for a drug's analgesic effects and that for its depressive effects on respiration.

    • Which of the following is NOT a reason why drugs vary in their effectiveness?

    <p>Different therapeutic indexes</p> Signup and view all the answers

    What is the definition of therapeutic index?

    <p>The ratio between the dose that produces the desired effect and the dose that produces toxic effects</p> Signup and view all the answers

    Why does a given dose of morphine produce more pain reduction than the same dose of aspirin?

    <p>Morphine suppresses the activity of neurons involved in pain perception, whereas aspirin reduces the production of a chemical involved in transmitting pain information</p> Signup and view all the answers

    What is the relationship between a drug's affinity and its effectiveness?

    <p>A drug with high affinity produces effects at a relatively low concentration, whereas a drug with low affinity must be administered in higher doses</p> Signup and view all the answers

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