Dopamine Replacement Drugs and Agonist Quiz

Carbidopa/Levodopa = Sinemet, Sinemet CR, Rytary, Duopa, Inbrija Entacapone + Carbidopa/Levodopa = Stalevo Opicapone = Ongentys Pramipexole = Mirapex, Mirapex ER

Ropinirole = Requip XL, Requip Rotigotine = Neupro Tolcapone = Tasmar

Carbidopa/Levodopa = Sinemet, Sinemet CR, Rytary, Duopa, Inbrija Entacapone + Carbidopa/Levodopa = Stalevo Opicapone = Ongentys Pramipexole = Mirapex, Mirapex ER

<p>Catechol-0-methyltransferase (COMT)</p> Signup and view all the answers

<p>Pramipexole</p> Signup and view all the answers

<p>Levodopa</p> Signup and view all the answers

<p>Carbidopa/Levodopa = Inhibits dopa decarboxylase enzyme, preventing peripheral metabolism of levodopa Entacapone (Comtan) + Carbidopa/Levodopa (Stalevo) = Inhibits the enzyme catechol-0-methyltransferase (COMT) to prevent peripheral conversion of levodopa Pramipexole (Mirapex, Mirapex ER) = Acts similar to dopamine at the dopamine receptor Opicapone (Ongentys) = Similar to other COMT inhibitors</p> Signup and view all the answers

<p>Carbidopa = Inhibits dopa decarboxylase enzyme Entacapone (Comtan) + Carbidopa/Levodopa (Stalevo) = Inhibits catechol-0-methyltransferase (COMT) Opicapone (Ongentys) = Inhibits catechol-0-methyltransferase (COMT) Ropinirole (Requip XL, Requip) = Does not inhibit any enzyme</p> Signup and view all the answers

<p>Pramipexole (Mirapex, Mirapex ER) = Acts similar to dopamine at the dopamine receptor Ropinirole (Requip XL, Requip) = Acts similar to dopamine at the dopamine receptor Rotigotine (Neupro) Patch = Acts similar to dopamine at the dopamine receptor Tolcapone (Tasmar) = Does not act similar to dopamine at the dopamine receptor</p> Signup and view all the answers

<p>25/100 mg PO TID</p> Signup and view all the answers

<p>1,600 mg/day</p> Signup and view all the answers

<p>0.375 mg PO daily</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>24 mg daily</p> Signup and view all the answers

<p>0.375 mg PO daily</p> Signup and view all the answers

<p>50/200 mg PO BID</p> Signup and view all the answers

<p>Carbidopa/Levodopa IR Tablets = $25/100$ mg PO TID Rytary (ER Capsule) = $23.75/95$ mg PO TID Pramipexole (Mirapex, Mirapex ER) IR = $0.125$ mg PO TID Apomorphine (Apokyn, Kynmobi) Injection (Subcutaneous) = $0.2$ ml (2 mg) SC PRN (up to 5x/day)</p> Signup and view all the answers

<p>Inbrija (Levodopa Capsule for Oral Inhaler) = $420$ mg/day Entacapone (Comtan) + Carbidopa/Levodopa (Stalevo) = $1,600$ mg/day Pramipexole (Mirapex, Mirapex ER) ER = $4.5$ mg daily Rotigotine (Neupro) Patch = $8$ mg/24 hours</p> Signup and view all the answers

<p>Carbidopa/Levodopa CR Tablets (Sinemet, Sinemet CR) = CR tablets can be cut in half - do not crush or chew Rytary (ER Capsule) = Can be taken whole or sprinkled on a small amount of applesauce Pramipexole (Mirapex, Mirapex ER) IR = Decrease dose if CrCl &lt; $50$ mL/min (90% renally excreted) Apomorphine (Apokyn, Kynmobi) Injection (Subcutaneous) = Titrate by $1$ mg every few days</p> Signup and view all the answers

<p>Carbidopa/Levodopa (Sinemet, Sinemet CR)</p> Signup and view all the answers

<p>Carbidopa/Levodopa (Sinemet, Sinemet CR)</p> Signup and view all the answers

<p>Apomorphine (Apokyn, Kynmobi)</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>Carbidopa/Levodopa = Non-selective MAO inhibitors within 14 days, Narrow-angle glaucoma COMT Inhibitors = No specific contraindications mentioned in the provided information Dopamine Agonists = No specific contraindications mentioned in the provided information Dopamine Agonist Injection for Advanced Disease = Do not use with 5HT·3 antagonists (e.g., ondansetron) due to severe hypotension and loss of consciousness</p> Signup and view all the answers

<p>Carbidopa/Levodopa (Sinemet, Sinemet CR) = Dopamine Replacement Drugs Entacapone (Comtan) + carbidopa/levodopa (Stalevo) = COMT Inhibitors Pramipexole (Mirapex, Mirapex ER) = Dopamine Agonists Apomorphine (Apokyn, Kynmobi) = Dopamine Agonist Injection for Advanced Disease</p> Signup and view all the answers

<p>Dopamine Replacement Drugs = Rytary, Duopa, Inbrija COMT Inhibitors = Opicapone (Ongentys), Tolcapone (Tasmar) Dopamine Agonists = Ropinirole (Requip XL, Requip), Rotigotine (Neupro) Dopamine Agonist Injection for Advanced Disease = Apomorphine (Apokyn, Kynmobi)</p> Signup and view all the answers

<p>Impulse control disorders</p> Signup and view all the answers

<p>Dry mouth</p> Signup and view all the answers

<p>Hypotension</p> Signup and view all the answers

<p>Side effects include nausea, dizziness, orthostasis, dyskinesias, hallucinations, psychosis, xerostomia, dystonias, confusion, brown/black/dark discoloring of bodily fluids, positive Coombs test, unusual sexual urges, priapism, uric acid. Rytary has the additional side effect of suicidal ideation and attempts, while Duopa can cause GI complications.</p> Signup and view all the answers

<p>Side effects include similar side effects to levodopa, such as dyskinesias. A decrease in levodopa dose of 10-30% is usually necessary when adding on a COMT inhibitor.</p> Signup and view all the answers

<p>Side effects include dizziness, nausea, vomiting, dry mouth, peripheral edema, constipation, hyperhidrosis, somnolence, orthostasis, hallucinations, dyskinesias, and impulse control disorders. Pramipexole can also cause postural deformity and rhabdomyolysis.</p> Signup and view all the answers

<p>Carbidopa/Levodopa (Sinemet, Sinemet CR) = Nausea, Dizziness, Orthostasis, Dyskinesias, Hallucinations, Psychosis Rytary = Suicidal ideation and attempts Duopa = GI complications Inbrija = Dry mouth, tongue pain</p> Signup and view all the answers

<p>Entacapone (Comtan) + carbidopa/levodopa (Stalevo) = Similar to levodopa, decrease in levodopa dose of 10-30% is usually necessary when adding on a COMT inhibitor Opicapone (Ongentys) = Dyskinesias can occur earlier with COMT inhibitors Tolcapone (Tasmar) = Similar to levodopa, decrease in levodopa dose of 10-30% is usually necessary when adding on a COMT inhibitor</p> Signup and view all the answers

<p>Pramipexole (Mirapex, Mirapex ER) = Postural deformity (e.g., bent spine, dropped head), Rhabdomyolysis Ropinirole (Requip XL, Requip) = Dizziness, Nausea, Vomiting, Dry mouth, Peripheral edema, Constipation Rotigotine (Neupro) = Hyperhidrosis, Somnolence (including sudden daytime sleep attacks), Orthostasis, Hallucinations, Dyskinesias, Impulse control disorders Apomorphine (Apokyn, Kynmobi) = Severe nausea/vomiting, Hypotension, Yawning, Dyskinesias, Somnolence, Dizziness, QT prolongation</p> Signup and view all the answers

<p>Dopamine agonist injection for advanced disease</p> Signup and view all the answers

<p>Apokyn = Apomorphine Kynmobi = Apomorphine Sinemet CR = Carbidopa/Levodopa CR Mirapex ER = Pramipexole ER</p> Signup and view all the answers

<p>Apomorphine = Dopamine agonist injection for advanced disease Carbidopa/Levodopa CR = Dopamine replacement Pramipexole ER = Dopamine agonist Entacapone = COMT inhibitor</p> Signup and view all the answers

<p>Apokyn = Apomorphine Kynmobi = Apomorphine Sinemet CR = Carbidopa/Levodopa Mirapex = Pramipexole</p> Signup and view all the answers