Dopamine Replacement Drugs and Agonist Quiz
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Questions and Answers

Match the following generic names of dopamine replacement drugs & agonists with their brand names:

Carbidopa/Levodopa = Sinemet, Sinemet CR, Rytary, Duopa, Inbrija Entacapone + Carbidopa/Levodopa = Stalevo Opicapone = Ongentys Pramipexole = Mirapex, Mirapex ER

Match these generic names of dopamine replacement drugs & agonists with their corresponding brand names:

Ropinirole = Requip XL, Requip Rotigotine = Neupro Tolcapone = Tasmar

Match the generic names of the following Parkinson's disease treatment drugs with their brand names:

Carbidopa/Levodopa = Sinemet, Sinemet CR, Rytary, Duopa, Inbrija Entacapone + Carbidopa/Levodopa = Stalevo Opicapone = Ongentys Pramipexole = Mirapex, Mirapex ER

Which enzyme do COMT inhibitors inhibit to prevent the peripheral conversion of levodopa?

<p>Catechol-0-methyltransferase (COMT) (B)</p> Signup and view all the answers

Which drug acts similar to dopamine at the dopamine receptor?

<p>Pramipexole (C)</p> Signup and view all the answers

Which drug is a precursor of dopamine?

<p>Levodopa (B)</p> Signup and view all the answers

Match the following drugs with their mechanism of action:

<p>Carbidopa/Levodopa = Inhibits dopa decarboxylase enzyme, preventing peripheral metabolism of levodopa Entacapone (Comtan) + Carbidopa/Levodopa (Stalevo) = Inhibits the enzyme catechol-0-methyltransferase (COMT) to prevent peripheral conversion of levodopa Pramipexole (Mirapex, Mirapex ER) = Acts similar to dopamine at the dopamine receptor Opicapone (Ongentys) = Similar to other COMT inhibitors</p> Signup and view all the answers

Match the following drugs with their action on enzymes:

<p>Carbidopa = Inhibits dopa decarboxylase enzyme Entacapone (Comtan) + Carbidopa/Levodopa (Stalevo) = Inhibits catechol-0-methyltransferase (COMT) Opicapone (Ongentys) = Inhibits catechol-0-methyltransferase (COMT) Ropinirole (Requip XL, Requip) = Does not inhibit any enzyme</p> Signup and view all the answers

Match the following drugs with their similarity to dopamine:

<p>Pramipexole (Mirapex, Mirapex ER) = Acts similar to dopamine at the dopamine receptor Ropinirole (Requip XL, Requip) = Acts similar to dopamine at the dopamine receptor Rotigotine (Neupro) Patch = Acts similar to dopamine at the dopamine receptor Tolcapone (Tasmar) = Does not act similar to dopamine at the dopamine receptor</p> Signup and view all the answers

Which of the following is the correct starting dose for Carbidopa/Levodopa IR tablets?

<p>25/100 mg PO TID (D)</p> Signup and view all the answers

What is the maximum daily dose of Entacapone (Comtan) when taken in combination with Carbidopa/Levodopa (Stalevo)?

<p>1,600 mg/day (A)</p> Signup and view all the answers

What is the starting dose for Pramipexole ER (Mirapex ER)?

<p>0.375 mg PO daily (A)</p> Signup and view all the answers

True or false: The starting dose of Carbidopa/Levodopa IR tablets is 25/100 mg PO TID?

<p>True (A)</p> Signup and view all the answers

True or false: Rytary (ER Capsule) has a starting dose of 23.75/95 mg PO TID for levodopa-naive patients?

<p>True (A)</p> Signup and view all the answers

True or false: The maximum daily dose of Apomorphine (Apokyn, Kynmobi) injection is 0.2 ml (2 mg) SC PRN (up to 5x/day)?

<p>True (A)</p> Signup and view all the answers

What is the maximum daily dose of Ropinirole XL (Requip XL)?

<p>24 mg daily</p> Signup and view all the answers

What is the starting dose for Pramipexole ER (Mirapex ER)?

<p>0.375 mg PO daily</p> Signup and view all the answers

What is the starting dose for Carbidopa/Levodopa CR tablets (Sinemet CR)?

<p>50/200 mg PO BID</p> Signup and view all the answers

Match the following dopamine replacement drugs and agonists with their starting doses:

<p>Carbidopa/Levodopa IR Tablets = $25/100$ mg PO TID Rytary (ER Capsule) = $23.75/95$ mg PO TID Pramipexole (Mirapex, Mirapex ER) IR = $0.125$ mg PO TID Apomorphine (Apokyn, Kynmobi) Injection (Subcutaneous) = $0.2$ ml (2 mg) SC PRN (up to 5x/day)</p> Signup and view all the answers

Match the following dopamine replacement drugs and agonists with their maximum doses:

<p>Inbrija (Levodopa Capsule for Oral Inhaler) = $420$ mg/day Entacapone (Comtan) + Carbidopa/Levodopa (Stalevo) = $1,600$ mg/day Pramipexole (Mirapex, Mirapex ER) ER = $4.5$ mg daily Rotigotine (Neupro) Patch = $8$ mg/24 hours</p> Signup and view all the answers

Match the following dopamine replacement drugs and agonists with their specific instructions or information:

<p>Carbidopa/Levodopa CR Tablets (Sinemet, Sinemet CR) = CR tablets can be cut in half - do not crush or chew Rytary (ER Capsule) = Can be taken whole or sprinkled on a small amount of applesauce Pramipexole (Mirapex, Mirapex ER) IR = Decrease dose if CrCl &lt; $50$ mL/min (90% renally excreted) Apomorphine (Apokyn, Kynmobi) Injection (Subcutaneous) = Titrate by $1$ mg every few days</p> Signup and view all the answers

Which one of these drugs is contraindicated in patients with non-selective MAO inhibitors within 14 days?

<p>Carbidopa/Levodopa (Sinemet, Sinemet CR) (C)</p> Signup and view all the answers

Which one of these drugs is contraindicated in patients with narrow-angle glaucoma?

<p>Carbidopa/Levodopa (Sinemet, Sinemet CR) (C)</p> Signup and view all the answers

Which one of these drugs should not be used with 5HT·3 antagonists (e.g., ondansetron) due to severe hypotension and loss of consciousness?

<p>Apomorphine (Apokyn, Kynmobi) (D)</p> Signup and view all the answers

True or false: Carbidopa/Levodopa is contraindicated in patients with narrow-angle glaucoma?

<p>True (A)</p> Signup and view all the answers

True or false: COMT inhibitors have no specific contraindications listed in the provided information?

<p>True (A)</p> Signup and view all the answers

True or false: Dopamine agonist injection should not be used with 5HT·3 antagonists due to the risk of severe hypotension and loss of consciousness?

<p>True (A)</p> Signup and view all the answers

Match the following Dopamine Replacement Drugs and Agonists with their contraindications:

<p>Carbidopa/Levodopa = Non-selective MAO inhibitors within 14 days, Narrow-angle glaucoma COMT Inhibitors = No specific contraindications mentioned in the provided information Dopamine Agonists = No specific contraindications mentioned in the provided information Dopamine Agonist Injection for Advanced Disease = Do not use with 5HT·3 antagonists (e.g., ondansetron) due to severe hypotension and loss of consciousness</p> Signup and view all the answers

Match the following drug names with their categories:

<p>Carbidopa/Levodopa (Sinemet, Sinemet CR) = Dopamine Replacement Drugs Entacapone (Comtan) + carbidopa/levodopa (Stalevo) = COMT Inhibitors Pramipexole (Mirapex, Mirapex ER) = Dopamine Agonists Apomorphine (Apokyn, Kynmobi) = Dopamine Agonist Injection for Advanced Disease</p> Signup and view all the answers

Match the following drug categories with their example drugs:

<p>Dopamine Replacement Drugs = Rytary, Duopa, Inbrija COMT Inhibitors = Opicapone (Ongentys), Tolcapone (Tasmar) Dopamine Agonists = Ropinirole (Requip XL, Requip), Rotigotine (Neupro) Dopamine Agonist Injection for Advanced Disease = Apomorphine (Apokyn, Kynmobi)</p> Signup and view all the answers

Which one of these is a side effect of Carbidopa/Levodopa (Sinemet, Sinemet CR)?

<p>Impulse control disorders (D)</p> Signup and view all the answers

Which one of these is a side effect of Entacapone (Comtan)?

<p>Dry mouth (B)</p> Signup and view all the answers

Which one of these is a side effect of Apomorphine (Apokyn, Kynmobi) injection?

<p>Hypotension (B)</p> Signup and view all the answers

What are the side effects of Carbidopa/Levodopa (Sinemet, Sinemet CR)?

<p>Side effects include nausea, dizziness, orthostasis, dyskinesias, hallucinations, psychosis, xerostomia, dystonias, confusion, brown/black/dark discoloring of bodily fluids, positive Coombs test, unusual sexual urges, priapism, uric acid. Rytary has the additional side effect of suicidal ideation and attempts, while Duopa can cause GI complications.</p> Signup and view all the answers

What are the side effects of Entacapone (Comtan) + carbidopa/levodopa (Stalevo)?

<p>Side effects include similar side effects to levodopa, such as dyskinesias. A decrease in levodopa dose of 10-30% is usually necessary when adding on a COMT inhibitor.</p> Signup and view all the answers

What are the side effects of Pramipexole (Mirapex, Mirapex ER)?

<p>Side effects include dizziness, nausea, vomiting, dry mouth, peripheral edema, constipation, hyperhidrosis, somnolence, orthostasis, hallucinations, dyskinesias, and impulse control disorders. Pramipexole can also cause postural deformity and rhabdomyolysis.</p> Signup and view all the answers

Match the following dopamine replacement drugs with their specific side effects:

<p>Carbidopa/Levodopa (Sinemet, Sinemet CR) = Nausea, Dizziness, Orthostasis, Dyskinesias, Hallucinations, Psychosis Rytary = Suicidal ideation and attempts Duopa = GI complications Inbrija = Dry mouth, tongue pain</p> Signup and view all the answers

Match the following COMT Inhibitors with their side effects:

<p>Entacapone (Comtan) + carbidopa/levodopa (Stalevo) = Similar to levodopa, decrease in levodopa dose of 10-30% is usually necessary when adding on a COMT inhibitor Opicapone (Ongentys) = Dyskinesias can occur earlier with COMT inhibitors Tolcapone (Tasmar) = Similar to levodopa, decrease in levodopa dose of 10-30% is usually necessary when adding on a COMT inhibitor</p> Signup and view all the answers

Match the following dopamine agonists with their specific side effects:

<p>Pramipexole (Mirapex, Mirapex ER) = Postural deformity (e.g., bent spine, dropped head), Rhabdomyolysis Ropinirole (Requip XL, Requip) = Dizziness, Nausea, Vomiting, Dry mouth, Peripheral edema, Constipation Rotigotine (Neupro) = Hyperhidrosis, Somnolence (including sudden daytime sleep attacks), Orthostasis, Hallucinations, Dyskinesias, Impulse control disorders Apomorphine (Apokyn, Kynmobi) = Severe nausea/vomiting, Hypotension, Yawning, Dyskinesias, Somnolence, Dizziness, QT prolongation</p> Signup and view all the answers

What is the mechanism of action of Apomorphine?

<p>Dopamine agonist injection for advanced disease (A)</p> Signup and view all the answers

Match the following drugs with their generic names:

<p>Apokyn = Apomorphine Kynmobi = Apomorphine Sinemet CR = Carbidopa/Levodopa CR Mirapex ER = Pramipexole ER</p> Signup and view all the answers

Match the following drugs with their mechanism of action:

<p>Apomorphine = Dopamine agonist injection for advanced disease Carbidopa/Levodopa CR = Dopamine replacement Pramipexole ER = Dopamine agonist Entacapone = COMT inhibitor</p> Signup and view all the answers

Match the following brand names with their corresponding drugs:

<p>Apokyn = Apomorphine Kynmobi = Apomorphine Sinemet CR = Carbidopa/Levodopa Mirapex = Pramipexole</p> Signup and view all the answers

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