43 Questions
Match the following generic names of dopamine replacement drugs & agonists with their brand names:
Carbidopa/Levodopa = Sinemet, Sinemet CR, Rytary, Duopa, Inbrija Entacapone + Carbidopa/Levodopa = Stalevo Opicapone = Ongentys Pramipexole = Mirapex, Mirapex ER
Match these generic names of dopamine replacement drugs & agonists with their corresponding brand names:
Ropinirole = Requip XL, Requip Rotigotine = Neupro Tolcapone = Tasmar
Match the generic names of the following Parkinson's disease treatment drugs with their brand names:
Carbidopa/Levodopa = Sinemet, Sinemet CR, Rytary, Duopa, Inbrija Entacapone + Carbidopa/Levodopa = Stalevo Opicapone = Ongentys Pramipexole = Mirapex, Mirapex ER
Which enzyme do COMT inhibitors inhibit to prevent the peripheral conversion of levodopa?
Catechol-0-methyltransferase (COMT)
Which drug acts similar to dopamine at the dopamine receptor?
Pramipexole
Which drug is a precursor of dopamine?
Levodopa
Match the following drugs with their mechanism of action:
Carbidopa/Levodopa = Inhibits dopa decarboxylase enzyme, preventing peripheral metabolism of levodopa Entacapone (Comtan) + Carbidopa/Levodopa (Stalevo) = Inhibits the enzyme catechol-0-methyltransferase (COMT) to prevent peripheral conversion of levodopa Pramipexole (Mirapex, Mirapex ER) = Acts similar to dopamine at the dopamine receptor Opicapone (Ongentys) = Similar to other COMT inhibitors
Match the following drugs with their action on enzymes:
Carbidopa = Inhibits dopa decarboxylase enzyme Entacapone (Comtan) + Carbidopa/Levodopa (Stalevo) = Inhibits catechol-0-methyltransferase (COMT) Opicapone (Ongentys) = Inhibits catechol-0-methyltransferase (COMT) Ropinirole (Requip XL, Requip) = Does not inhibit any enzyme
Match the following drugs with their similarity to dopamine:
Pramipexole (Mirapex, Mirapex ER) = Acts similar to dopamine at the dopamine receptor Ropinirole (Requip XL, Requip) = Acts similar to dopamine at the dopamine receptor Rotigotine (Neupro) Patch = Acts similar to dopamine at the dopamine receptor Tolcapone (Tasmar) = Does not act similar to dopamine at the dopamine receptor
Which of the following is the correct starting dose for Carbidopa/Levodopa IR tablets?
25/100 mg PO TID
What is the maximum daily dose of Entacapone (Comtan) when taken in combination with Carbidopa/Levodopa (Stalevo)?
1,600 mg/day
What is the starting dose for Pramipexole ER (Mirapex ER)?
0.375 mg PO daily
True or false: The starting dose of Carbidopa/Levodopa IR tablets is 25/100 mg PO TID?
True
True or false: Rytary (ER Capsule) has a starting dose of 23.75/95 mg PO TID for levodopa-naive patients?
True
True or false: The maximum daily dose of Apomorphine (Apokyn, Kynmobi) injection is 0.2 ml (2 mg) SC PRN (up to 5x/day)?
True
What is the maximum daily dose of Ropinirole XL (Requip XL)?
24 mg daily
What is the starting dose for Pramipexole ER (Mirapex ER)?
0.375 mg PO daily
What is the starting dose for Carbidopa/Levodopa CR tablets (Sinemet CR)?
50/200 mg PO BID
Match the following dopamine replacement drugs and agonists with their starting doses:
Carbidopa/Levodopa IR Tablets = $25/100$ mg PO TID Rytary (ER Capsule) = $23.75/95$ mg PO TID Pramipexole (Mirapex, Mirapex ER) IR = $0.125$ mg PO TID Apomorphine (Apokyn, Kynmobi) Injection (Subcutaneous) = $0.2$ ml (2 mg) SC PRN (up to 5x/day)
Match the following dopamine replacement drugs and agonists with their maximum doses:
Inbrija (Levodopa Capsule for Oral Inhaler) = $420$ mg/day Entacapone (Comtan) + Carbidopa/Levodopa (Stalevo) = $1,600$ mg/day Pramipexole (Mirapex, Mirapex ER) ER = $4.5$ mg daily Rotigotine (Neupro) Patch = $8$ mg/24 hours
Match the following dopamine replacement drugs and agonists with their specific instructions or information:
Carbidopa/Levodopa CR Tablets (Sinemet, Sinemet CR) = CR tablets can be cut in half - do not crush or chew Rytary (ER Capsule) = Can be taken whole or sprinkled on a small amount of applesauce Pramipexole (Mirapex, Mirapex ER) IR = Decrease dose if CrCl < $50$ mL/min (90% renally excreted) Apomorphine (Apokyn, Kynmobi) Injection (Subcutaneous) = Titrate by $1$ mg every few days
Which one of these drugs is contraindicated in patients with non-selective MAO inhibitors within 14 days?
Carbidopa/Levodopa (Sinemet, Sinemet CR)
Which one of these drugs is contraindicated in patients with narrow-angle glaucoma?
Carbidopa/Levodopa (Sinemet, Sinemet CR)
Which one of these drugs should not be used with 5HT·3 antagonists (e.g., ondansetron) due to severe hypotension and loss of consciousness?
Apomorphine (Apokyn, Kynmobi)
True or false: Carbidopa/Levodopa is contraindicated in patients with narrow-angle glaucoma?
True
True or false: COMT inhibitors have no specific contraindications listed in the provided information?
True
True or false: Dopamine agonist injection should not be used with 5HT·3 antagonists due to the risk of severe hypotension and loss of consciousness?
True
Match the following Dopamine Replacement Drugs and Agonists with their contraindications:
Carbidopa/Levodopa = Non-selective MAO inhibitors within 14 days, Narrow-angle glaucoma COMT Inhibitors = No specific contraindications mentioned in the provided information Dopamine Agonists = No specific contraindications mentioned in the provided information Dopamine Agonist Injection for Advanced Disease = Do not use with 5HT·3 antagonists (e.g., ondansetron) due to severe hypotension and loss of consciousness
Match the following drug names with their categories:
Carbidopa/Levodopa (Sinemet, Sinemet CR) = Dopamine Replacement Drugs Entacapone (Comtan) + carbidopa/levodopa (Stalevo) = COMT Inhibitors Pramipexole (Mirapex, Mirapex ER) = Dopamine Agonists Apomorphine (Apokyn, Kynmobi) = Dopamine Agonist Injection for Advanced Disease
Match the following drug categories with their example drugs:
Dopamine Replacement Drugs = Rytary, Duopa, Inbrija COMT Inhibitors = Opicapone (Ongentys), Tolcapone (Tasmar) Dopamine Agonists = Ropinirole (Requip XL, Requip), Rotigotine (Neupro) Dopamine Agonist Injection for Advanced Disease = Apomorphine (Apokyn, Kynmobi)
Which one of these is a side effect of Carbidopa/Levodopa (Sinemet, Sinemet CR)?
Impulse control disorders
Which one of these is a side effect of Entacapone (Comtan)?
Dry mouth
Which one of these is a side effect of Apomorphine (Apokyn, Kynmobi) injection?
Hypotension
What are the side effects of Carbidopa/Levodopa (Sinemet, Sinemet CR)?
Side effects include nausea, dizziness, orthostasis, dyskinesias, hallucinations, psychosis, xerostomia, dystonias, confusion, brown/black/dark discoloring of bodily fluids, positive Coombs test, unusual sexual urges, priapism, uric acid. Rytary has the additional side effect of suicidal ideation and attempts, while Duopa can cause GI complications.
What are the side effects of Entacapone (Comtan) + carbidopa/levodopa (Stalevo)?
Side effects include similar side effects to levodopa, such as dyskinesias. A decrease in levodopa dose of 10-30% is usually necessary when adding on a COMT inhibitor.
What are the side effects of Pramipexole (Mirapex, Mirapex ER)?
Side effects include dizziness, nausea, vomiting, dry mouth, peripheral edema, constipation, hyperhidrosis, somnolence, orthostasis, hallucinations, dyskinesias, and impulse control disorders. Pramipexole can also cause postural deformity and rhabdomyolysis.
Match the following dopamine replacement drugs with their specific side effects:
Carbidopa/Levodopa (Sinemet, Sinemet CR) = Nausea, Dizziness, Orthostasis, Dyskinesias, Hallucinations, Psychosis Rytary = Suicidal ideation and attempts Duopa = GI complications Inbrija = Dry mouth, tongue pain
Match the following COMT Inhibitors with their side effects:
Entacapone (Comtan) + carbidopa/levodopa (Stalevo) = Similar to levodopa, decrease in levodopa dose of 10-30% is usually necessary when adding on a COMT inhibitor Opicapone (Ongentys) = Dyskinesias can occur earlier with COMT inhibitors Tolcapone (Tasmar) = Similar to levodopa, decrease in levodopa dose of 10-30% is usually necessary when adding on a COMT inhibitor
Match the following dopamine agonists with their specific side effects:
Pramipexole (Mirapex, Mirapex ER) = Postural deformity (e.g., bent spine, dropped head), Rhabdomyolysis Ropinirole (Requip XL, Requip) = Dizziness, Nausea, Vomiting, Dry mouth, Peripheral edema, Constipation Rotigotine (Neupro) = Hyperhidrosis, Somnolence (including sudden daytime sleep attacks), Orthostasis, Hallucinations, Dyskinesias, Impulse control disorders Apomorphine (Apokyn, Kynmobi) = Severe nausea/vomiting, Hypotension, Yawning, Dyskinesias, Somnolence, Dizziness, QT prolongation
What is the mechanism of action of Apomorphine?
Dopamine agonist injection for advanced disease
Match the following drugs with their generic names:
Apokyn = Apomorphine Kynmobi = Apomorphine Sinemet CR = Carbidopa/Levodopa CR Mirapex ER = Pramipexole ER
Match the following drugs with their mechanism of action:
Apomorphine = Dopamine agonist injection for advanced disease Carbidopa/Levodopa CR = Dopamine replacement Pramipexole ER = Dopamine agonist Entacapone = COMT inhibitor
Match the following brand names with their corresponding drugs:
Apokyn = Apomorphine Kynmobi = Apomorphine Sinemet CR = Carbidopa/Levodopa Mirapex = Pramipexole
Test your knowledge on the generic and brand names of dopamine replacement drugs and agonists used to treat Parkinson's Disease. Identify the correct names for medications like Carbidopa/Levodopa, Entacapone, Opicapone, and Pramipexole. Challenge yourself with this quiz and enhance your understanding of Parkinson's Disease treatment.
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