Dopamine Pathways and Neuroleptic Side Effects

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Questions and Answers

Typical antipsychotics, such as Haloperidol, can cause extra pyramidal side effects due to dopamine receptor blockade in the nigrostriatal pathway.

True (A)

Atypical antipsychotics, such as Olanzapine, are less effective against positive symptoms of schizophrenia compared to typical antipsychotics.

False (B)

Neuroleptic malignant syndrome (NMS) is a rare side effect of antipsychotic medication, occurring in approximately 0.01% of patients.

False (B)

Dantrolene is a specific antidote for Neuroleptic malignant syndrome (NMS).

<p>False (B)</p> Signup and view all the answers

Atypical antipsychotics, such as Clozapine, are associated with a higher risk of Neuroleptic malignant syndrome (NMS) compared to typical antipsychotics.

<p>False (B)</p> Signup and view all the answers

Chlorpromazine is a type of butyrophenone.

<p>False (B)</p> Signup and view all the answers

Typical antipsychotics work by inhibiting D1 receptors.

<p>False (B)</p> Signup and view all the answers

Flupenthixol is a type of thioxanthene.

<p>True (A)</p> Signup and view all the answers

Sulpride is a type of indole derivative.

<p>False (B)</p> Signup and view all the answers

Haloperidol is a type of phenothiazine.

<p>False (B)</p> Signup and view all the answers

Flashcards

Extrapyramidal side effects

Dopamine receptor blockade in the nigrostriatal pathway by typical antipsychotics can cause these side effects.

Atypical antipsychotics efficacy

Atypical antipsychotics are generally MORE effective against positive symptoms.

NMS frequency

NMS is a rare but serious side effect of antipsychotics, with a frequency HIGHER than 0.01%.

Dantrolene for NMS

Dantrolene is NOT a specific antidote for NMS.

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NMS risk (atypical vs typical)

Atypical antipsychotics are associated with a LOWER risk, compared to typical antipsychotics.

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Chlorpromazine class

Chlorpromazine is a phenothiazine.

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Typical antipsychotics receptor

Typical antipsychotics work by inhibiting D2 receptors, not D1.

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Flupenthixol class

Flupenthixol belongs to the thioxanthene class of antipsychotics.

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Sulpride drug class

Sulpride is a substituted benzamide antipsychotic.

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