8 Questions
What is the therapeutic lag in schizophrenia patients despite blocking receptors within 30 mins?
2-3 months
What is the main implication of dopamine dysfunction in the PFC for cognitive decline in schizophrenia?
Reduction in dopamine levels in the PFC contributes to cognitive decline
What is the primary limitation of the dopamine hypothesis for antipsychotic effects?
Only 1/3 of schizophrenia patients respond to d2 antagonists
What is the relationship between high drug potency and d2 affinity according to the text?
High drug potency is associated with high d2 affinity
What is the primary mechanism of action of clinically-effective antipsychotic drugs?
Blocking striatal dopamine receptors
What is the main reason for the high discontinuation rate of chlorpromazine?
Induction of extreme slowness and robotic-like movements
What is the relationship between drug potency and affinity for D2 receptors?
High affinity = high potency
What does the 1/3 efficacy rate of antipsychotics on schizophrenia patients despite D2 receptor blockade suggest?
Dopamine is not the sole factor in schizophrenia
Test your knowledge of the dopamine hypothesis in schizophrenia and the development of chlorpromazine as the first modern medical treatment for the condition. Explore the impact of neuroleptic drugs on D2 dopamine receptor antagonists.
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