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Questions and Answers
What is the therapeutic lag in schizophrenia patients despite blocking receptors within 30 mins?
What is the therapeutic lag in schizophrenia patients despite blocking receptors within 30 mins?
- 2-3 months (correct)
- 1-2 weeks
- 6-8 weeks
- 4-6 weeks
What is the main implication of dopamine dysfunction in the PFC for cognitive decline in schizophrenia?
What is the main implication of dopamine dysfunction in the PFC for cognitive decline in schizophrenia?
- Dopamine dysfunction only affects positive symptoms, not cognitive decline
- Dopamine has no impact on cognitive decline in schizophrenia
- Reduction in dopamine levels in the PFC contributes to cognitive decline (correct)
- Increase in dopamine levels in the PFC contributes to cognitive decline
What is the primary limitation of the dopamine hypothesis for antipsychotic effects?
What is the primary limitation of the dopamine hypothesis for antipsychotic effects?
- Dopamine dysfunction affects both positive and negative symptoms equally
- Dopaminergic drugs are equally effective for all schizophrenia patients
- Only 1/3 of schizophrenia patients respond to d2 antagonists (correct)
- Dopamine levels are uniformly affected across striatum and PFC
What is the relationship between high drug potency and d2 affinity according to the text?
What is the relationship between high drug potency and d2 affinity according to the text?
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What is the primary mechanism of action of clinically-effective antipsychotic drugs?
What is the primary mechanism of action of clinically-effective antipsychotic drugs?
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What is the main reason for the high discontinuation rate of chlorpromazine?
What is the main reason for the high discontinuation rate of chlorpromazine?
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What is the relationship between drug potency and affinity for D2 receptors?
What is the relationship between drug potency and affinity for D2 receptors?
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What does the 1/3 efficacy rate of antipsychotics on schizophrenia patients despite D2 receptor blockade suggest?
What does the 1/3 efficacy rate of antipsychotics on schizophrenia patients despite D2 receptor blockade suggest?
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