Dopamine Hypothesis in Schizophrenia
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Questions and Answers

What is the therapeutic lag in schizophrenia patients despite blocking receptors within 30 mins?

  • 2-3 months (correct)
  • 1-2 weeks
  • 6-8 weeks
  • 4-6 weeks

    • What is the main implication of dopamine dysfunction in the PFC for cognitive decline in schizophrenia?

  • Dopamine dysfunction only affects positive symptoms, not cognitive decline
  • Dopamine has no impact on cognitive decline in schizophrenia
  • Reduction in dopamine levels in the PFC contributes to cognitive decline (correct)
  • Increase in dopamine levels in the PFC contributes to cognitive decline

    • What is the primary limitation of the dopamine hypothesis for antipsychotic effects?

  • Dopamine dysfunction affects both positive and negative symptoms equally
  • Dopaminergic drugs are equally effective for all schizophrenia patients
  • Only 1/3 of schizophrenia patients respond to d2 antagonists (correct)
  • Dopamine levels are uniformly affected across striatum and PFC

    • What is the relationship between high drug potency and d2 affinity according to the text?

    <p>High drug potency is associated with high d2 affinity</p> Signup and view all the answers

    What is the primary mechanism of action of clinically-effective antipsychotic drugs?

    <p>Blocking striatal dopamine receptors</p> Signup and view all the answers

    What is the main reason for the high discontinuation rate of chlorpromazine?

    <p>Induction of extreme slowness and robotic-like movements</p> Signup and view all the answers

    What is the relationship between drug potency and affinity for D2 receptors?

    <p>High affinity = high potency</p> Signup and view all the answers

    What does the 1/3 efficacy rate of antipsychotics on schizophrenia patients despite D2 receptor blockade suggest?

    <p>Dopamine is not the sole factor in schizophrenia</p> Signup and view all the answers

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