Dopamine Hypothesis in Schizophrenia
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Questions and Answers

What is the therapeutic lag in schizophrenia patients despite blocking receptors within 30 mins?

  • 1-2 months
  • 4-6 weeks
  • 2-3 months (correct)
  • 6-8 weeks

    • Which symptoms are not improved among the lucky 1/3 where antipsychotics work?

  • Positive symptoms
  • Affective symptoms
  • Negative symptoms (correct)
  • Cognitive symptoms

    • What is the main limitation of the dopamine hypothesis in schizophrenia treatment?

  • Lack of d2 antagonists targeting striatum
  • High drug potency
  • Only 1/3 efficacy in schizophrenia patients (correct)
  • Inability to target PFC dopamine levels

    • What accounts for cognitive decline in schizophrenia according to the text?

    <p>Reduction in dopamine in the PFC</p> Signup and view all the answers

    What is the primary function of chlorpromazine in treating schizophrenia?

    <p>Blocking striatal dopamine</p> Signup and view all the answers

    Where are D2 dopamine receptors most prevalent?

    <p>Striatum (basal ganglia)</p> Signup and view all the answers

    What is the relationship between drug potency and affinity for D2 receptors?

    <p>High affinity = high potency</p> Signup and view all the answers

    What is a limitation of the dopamine hypothesis in explaining schizophrenia?

    <p>1/3 efficacy rate of antipsychotics on schizophrenia patients despite D2 receptor blockade in all patients</p> Signup and view all the answers

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