8 Questions
What is the therapeutic lag in schizophrenia patients despite blocking receptors within 30 mins?
2-3 months
Which symptoms are not improved among the lucky 1/3 where antipsychotics work?
Negative symptoms
What is the main limitation of the dopamine hypothesis in schizophrenia treatment?
Only 1/3 efficacy in schizophrenia patients
What accounts for cognitive decline in schizophrenia according to the text?
Reduction in dopamine in the PFC
What is the primary function of chlorpromazine in treating schizophrenia?
Blocking striatal dopamine
Where are D2 dopamine receptors most prevalent?
Striatum (basal ganglia)
What is the relationship between drug potency and affinity for D2 receptors?
High affinity = high potency
What is a limitation of the dopamine hypothesis in explaining schizophrenia?
1/3 efficacy rate of antipsychotics on schizophrenia patients despite D2 receptor blockade in all patients
Test your knowledge about the dopamine hypothesis in schizophrenia and the discovery of chlorpromazine as a treatment for the disorder.
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