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Questions and Answers
What is the main concern with using memantine concurrently with other drugs?
What is the main concern with using memantine concurrently with other drugs?
- Increased neuromuscular blockade and prolonged respiratory depression
- Decreased anti-AChE effects of neostigmine or pyridostigmine
- Interference with anticholinergic activity
- Accumulation of the drug leading to increased adverse effects (correct)
Which of the following drug combinations should be avoided due to the risk of synergistic effects?
Which of the following drug combinations should be avoided due to the risk of synergistic effects?
- Neostigmine and aminoglycoside antibiotics
- Cholinomimetics and other cholinesterase inhibitors (correct)
- Pyridostigmine and corticosteroids
- Memantine and succinylcholine
What is the recommended course of action if a patient is taking corticosteroids concurrently with neostigmine or pyridostigmine?
What is the recommended course of action if a patient is taking corticosteroids concurrently with neostigmine or pyridostigmine?
- Increase the dose of neostigmine or pyridostigmine
- Avoid concurrent use or provide respiratory support as needed (correct)
- Discontinue the corticosteroids immediately
- Monitor the patient for decreased anti-AChE effects
What is the primary concern with using magnesium concurrently with neostigmine or pyridostigmine?
What is the primary concern with using magnesium concurrently with neostigmine or pyridostigmine?
What is the recommended course of action if a patient is taking local or general anesthetics, or antiarrhythmic drugs, concurrently with neostigmine?
What is the recommended course of action if a patient is taking local or general anesthetics, or antiarrhythmic drugs, concurrently with neostigmine?
What is the primary concern with using rivastigmine concurrently with anticholinergic drugs?
What is the primary concern with using rivastigmine concurrently with anticholinergic drugs?
What is the effect of donepezil on anticholinergics?
What is the effect of donepezil on anticholinergics?
What is the recommended action when donepezil is administered with bethanechol or succinylcholine?
What is the recommended action when donepezil is administered with bethanechol or succinylcholine?
What is the potential effect of donepezil on drugs metabolized by CYP450 2D6 and 3A4 isoenzymes, such as ketoconazole and quinidine?
What is the potential effect of donepezil on drugs metabolized by CYP450 2D6 and 3A4 isoenzymes, such as ketoconazole and quinidine?
Which of the following statements regarding the interaction between galantamine and cimetidine is correct?
Which of the following statements regarding the interaction between galantamine and cimetidine is correct?
What is the effect of paroxetine on galantamine?
What is the effect of paroxetine on galantamine?
What is the recommended action when memantine is administered with drugs, diets, or clinical states that make urine alkaline?
What is the recommended action when memantine is administered with drugs, diets, or clinical states that make urine alkaline?
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