12 Questions
What is the main concern with using memantine concurrently with other drugs?
Accumulation of the drug leading to increased adverse effects
Which of the following drug combinations should be avoided due to the risk of synergistic effects?
Cholinomimetics and other cholinesterase inhibitors
What is the recommended course of action if a patient is taking corticosteroids concurrently with neostigmine or pyridostigmine?
Avoid concurrent use or provide respiratory support as needed
What is the primary concern with using magnesium concurrently with neostigmine or pyridostigmine?
Magnesium's direct depressant effect on skeletal muscle may antagonize the beneficial effects of the anti-AChE drugs
What is the recommended course of action if a patient is taking local or general anesthetics, or antiarrhythmic drugs, concurrently with neostigmine?
Increase the dose of neostigmine
What is the primary concern with using rivastigmine concurrently with anticholinergic drugs?
Rivastigmine may interfere with the activity of the anticholinergic drugs
What is the effect of donepezil on anticholinergics?
Donepezil antagonizes the activity of anticholinergics
What is the recommended action when donepezil is administered with bethanechol or succinylcholine?
Reduce the bethanechol dose if they must be given concurrently
What is the potential effect of donepezil on drugs metabolized by CYP450 2D6 and 3A4 isoenzymes, such as ketoconazole and quinidine?
Donepezil may inhibit the metabolism of these drugs
Which of the following statements regarding the interaction between galantamine and cimetidine is correct?
Cimetidine increases the bioavailability of galantamine by 16%
What is the effect of paroxetine on galantamine?
Paroxetine increases the bioavailability of galantamine by 40%
What is the recommended action when memantine is administered with drugs, diets, or clinical states that make urine alkaline?
Avoid concurrent use or monitor for increased drug effects
Test your knowledge on the interactions of donepezil with different drugs. Learn about how donepezil antagonizes anticholinergics, interacts with NSAIDs, and affects the binding of drugs metabolized by CYP450 enzymes.
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