DNA Replication Mechanisms: Part 2

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What is the primary function of DNA helicase in DNA replication?

To correct accidental incorporation of ribonucleotides

To open up the DNA double helix in front of the replication fork (correct)

To prevent DNA tangling during replication

To hold the DNA polymerase onto the DNA

How many subunits of DNA polymerase are found in eukaryotes?

11

3 (correct)

1

6

What is the purpose of the sliding ring in DNA replication?

To remove replication errors

To open up the DNA double helix

To hold the moving DNA polymerase onto the DNA (correct)

To prevent DNA tangling

What type of repair system removes replication errors that remain in the wake of the replication machine?

Mismatch repair Signup and view all the answers

How many subunits are found in the DNA polymerase of prokaryotes?

6 Signup and view all the answers

What is the main function of DNA topoisomerases during DNA replication?

To prevent DNA tangling Signup and view all the answers

What is the characteristic of the replication origin in terms of DNA sequence?

Rich in AT sequence Signup and view all the answers

What is the function of the initiator protein in DNA replication?

To destabilize the double helix Signup and view all the answers

Where does DNA replication occur in the cell cycle in eukaryotes?

During interphase Signup and view all the answers

What is the function of telomerase in DNA replication?

To replicate the ends of chromosomes Signup and view all the answers

What is the difference between bacterial and eukaryotic chromosomes in terms of DNA replication?

Eukaryotic chromosomes have multiple origins, while bacterial chromosomes have a single origin Signup and view all the answers

What is the consequence of the high concentration of ribonucleotides in the cell?

DNA synthesis is favored Signup and view all the answers

What is the primary function of histone chaperones in DNA replication?

To restore the full complement of histones behind the replication fork Signup and view all the answers

What is the consequence of the lagging-strand replication machinery reaching the end of the chromosome?

The replication of incomplete DNA product with a short ssDNA region Signup and view all the answers

What is the role of telomerase in DNA replication?

To replicate the ends of chromosomes Signup and view all the answers

What is the function of the ORC in DNA replication?

To ensure that each region of the DNA is replicated once and only once Signup and view all the answers

What is the composition of telomerase?

Multiple protein subunits and RNA Signup and view all the answers

What is the result of the replication fork reaching the end of the chromosome in the next round of replication?

A shortened DNA product lacking the region that was not fully copied Signup and view all the answers

What happens to the histones in front of the replication fork?

They are disassembled and facilitated by chaperone FACT Signup and view all the answers

What is the process by which DNA replication is terminated?

The ordered disassembly of the replication fork Signup and view all the answers